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AbbVie : Investigators at AbbVie Detail Findings in Pharmaceutical and Biomedical Analysis (Use of ionic liquids as headspace gas chromatography diluents for...

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10/05/2017 | 11:53pm CET

Investigators at AbbVie Detail Findings in Pharmaceutical and Biomedical Analysis (Use of ionic liquids as headspace gas chromatography diluents for the analysis of residual solvents in pharmaceuticals)

By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Biotechnology - Pharmaceutical and Biomedical Analysis. According to news reporting originating in North Chicago, Illinois, by NewsRx journalists, research stated, "In this study, two ionic liquids (ILs), 1-butyl-3-methylimidazolium bis[(trifluoromethyl)sulfonyl]imide ([BMIM][NTf2]) and trihexyltetradecylphosphonium bis[(trifluoromethyl)sulfonyl]imide ([P-66614][NTf2]) were examined as contemporary diluents for residual solvent analysis using static headspace gas chromatography (SHS-GC) coupled with flame ionization detection (FID). ILs are a class of non-molecular solvents featuring negligible vapor pressure and high thermal stabilities."

The news reporters obtained a quote from the research from AbbVie, "Owing to these favorable properties, ILs have potential to enable superior sensitivity and reduced interference, compared to conventional organic diluents, at high headspace incubation temperatures. By employing the [BMIM][NTf2] IL as a diluent, a 25-fold improvement in limit of detection (LOD) was observed with respect to traditional HS-GC diluents, such as N-methylpyrrolidone (NMP). The established IL-based method demonstrated LODs ranging from 5.8 parts-per-million (ppm) to 20 ppm of residual solvents in drug substances. The optimization of headspace extraction conditions was performed prior to method validation. An incubation temperature of 140 degrees C and a 15 min incubation time provided the best sensitivity for the analysis. Under optimized experimental conditions, the mass of residual solvents partitioned in the headspace was higher when using [BMIM][NTf2] than NMP as a diluent. The analytical performance was demonstrated by determining the repeatability, accuracy, and linearity of the method. Linear ranges of up to two orders of magnitude were obtained for class 3 solvents. Excellent analyte recoveries were obtained in the presence of three different active pharmaceutical ingredients."

According to the news reporters, the research concluded: "Owing to its robustness, high throughput, and superior sensitivity, the HS-GC IL-based method can be used as an alternative to existing residual solvent methods."

For more information on this research see: Use of ionic liquids as headspace gas chromatography diluents for the analysis of residual solvents in pharmaceuticals. Journal of Pharmaceutical and Biomedical Analysis, 2017;145():879-886. Journal of Pharmaceutical and Biomedical Analysis can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Journal of Pharmaceutical and Biomedical Analysis - www.journals.elsevier.com/journal-of-pharmaceutical-and-biomedical-analysis/)

Our news correspondents report that additional information may be obtained by contacting G.K. Webster, AbbVie Inc, North Chicago, IL 60064, United States. Additional authors for this research include T.D. Ho, J.L. Anderson and O. Nacham (see also Biotechnology - Pharmaceutical and Biomedical Analysis).

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1016/j.jpba.2017.05.033. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

Keywords for this news article include: North Chicago, Illinois, United States, North and Central America, Pharmaceutical and Biomedical Analysis, Biotechnology, AbbVie.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2017, NewsRx LLC

(c) 2017 NewsRx LLC, source Health Newsletters

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