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Research Results from AbbVie Update Understanding of Medicinal Chemistry (Beyond the Rule of 5: Lessons Learned from AbbVie's Drugs and Compound...

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10/05/2017 | 05:58pm CET

Research Results from AbbVie Update Understanding of Medicinal Chemistry (Beyond the Rule of 5: Lessons Learned from AbbVie's Drugs and Compound Collection)

By a News Reporter-Staff News Editor at Drug Week -- New research on Health and Medicine - Medicinal Chemistry is the subject of a report. According to news reporting originating from North Chicago, Illinois, by NewsRx correspondents, research stated, "Recently, there has been an increasing focus on the pursuit of targets considered to be less druggable that offer potential for development of promising new therapeutic agents for the treatment of diseases with large unmet medical need, particularly in the areas of oncology and virology. However, conducting drug discovery campaigns in 'beyond rule of 5' (bRo5) chemical space presents a significant drug design and development challenge to medicinal chemists to achieve acceptable oral pharmacokinetics."

Our news editors obtained a quote from the research from AbbVie, "Retrospective analysis of past successes and failures in drug discovery bRo5 may shed light on the key principles that contribute to the oral bioavailability of successful bRo5 compounds and improve the efficiency of drug design for future projects. We present here highlights and case studies of lessons learned from discovery of bRo5 compounds."

According to the news editors, the research concluded: "A simple multiparametric scoring function (AB-MPS) was devised that correlated preclinical PK results with cLogD, number of rotatable bonds, and number of aromatic rings."

For more information on this research see: Beyond the Rule of 5: Lessons Learned from AbbVie's Drugs and Compound Collection. Journal of Medicinal Chemistry, 2017;():. (American Chemical Society - www.acs.org; Journal of Medicinal Chemistry - www.pubs.acs.org/journal/jmcmar)

The news editors report that additional information may be obtained by contacting D.A. DeGoey, Research and Development, AbbVie Inc , 1 North Waukegan Road, North Chicago, Illinois 60064, United States. Additional authors for this research include H.J. Chen, P.B. Cox and M.D Wendt (see also Health and Medicine - Medicinal Chemistry).

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1021/acs.jmedchem.7b00717. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

Keywords for this news article include: Illinois, North Chicago, United States, Drugs and Therapies, Health and Medicine, Medicinal Chemistry, North and Central America.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2017, NewsRx LLC

(c) 2017 NewsRx LLC, source Health Newsletters

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Financials ($)
Sales 2017 27 998 M
EBIT 2017 11 955 M
Net income 2017 7 316 M
Debt 2017 26 790 M
Yield 2017 2,70%
P/E ratio 2017 20,76
P/E ratio 2018 16,37
EV / Sales 2017 6,44x
EV / Sales 2018 5,70x
Capitalization 154 B
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