THOUSAND OAKS, Calif., April 28, 2016 /PRNewswire/ -- Amgen (NASDAQ:AMGN) today announced financial results for the first quarter of 2016. Key results include:


    --  Total revenues increased 10 percent versus the first quarter of 2015 to
        $5,527 million, with 7 percent product sales growth driven by Enbrel(®)
        (etanercept), Prolia(®) (denosumab), Aranesp(®) (darbepoetin alfa),
        Neulasta(®) (pegfilgrastim), Kyprolis(®) (carfilzomib) and XGEVA(®)
        (denosumab).
    --  Adjusted EPS grew 17 percent versus the first quarter of 2015 to $2.90
        driven by higher revenues and higher operating margins.
    --  Adjusted operating income increased 17 percent to $2,859 million and
        adjusted operating margin improved by 4.4 percentage points to 54.6
        percent.
    --  GAAP EPS were $2.50 compared to $2.11 and GAAP operating income was
        $2,402 million compared to $2,022 million.
    --  Free cash flow was $1.8 billion compared to $1.4 billion in the first
        quarter of 2015 driven by higher revenues and higher operating income.

"We are off to a strong start in 2016 delivering results for the year and laying groundwork for our long-term growth with innovative new product launches globally," said Robert A. Bradway, chairman and chief executive officer.



    $Millions, except EPS and percentages Q1'16        Q1'15        YOY  
                                          -----        -----        -----


    Total Revenues                              $5,527       $5,033       10%

    Adjusted Operating Income                   $2,859       $2,449       17%

    Adjusted Net Income                         $2,203       $1,911       15%

    Adjusted EPS                                 $2.90        $2.48       17%


    GAAP Operating Income                       $2,402       $2,022       19%

    GAAP Net Income                             $1,900       $1,623       17%

    GAAP EPS                                     $2.50        $2.11       18%
    --------                                     -----        -----       ---


    References in this release to
     "adjusted" measures, measures
     presented "on an adjusted basis" and
     to free cash flow refer to non-GAAP
     financial measures.  These adjustments
     and other items are presented on the
     attached reconciliations.

Product Sales Performance


    --  Total product sales increased 7 percent for the first quarter of 2016
        versus the first quarter of 2015. The increase was driven by ENBREL,
        Prolia, Aranesp, Neulasta, Kyprolis and XGEVA.
    --  ENBREL sales increased 24 percent driven by net selling price and
        declining inventory levels in the prior year period, offset partially by
        the impact of competition.
    --  Neulasta sales increased 4 percent driven by both higher unit demand and
        net selling price in the United States (U.S.).
    --  Aranesp sales increased 11 percent. Unit demand grew due to a shift by
        some U.S. dialysis customers from EPOGEN(®) (epoetin alfa) to Aranesp.
        Unit demand growth was offset partially by unfavorable changes in net
        selling price.
    --  XGEVA sales increased 11 percent driven by higher unit demand.
    --  Sensipar/Mimpara(®) (cinacalcet) sales increased 10 percent driven by
        net selling price and higher unit demand, offset partially by
        unfavorable changes in inventory levels.
    --  Prolia sales increased 29 percent driven by higher unit demand.
    --  EPOGEN sales decreased 44 percent driven by the impact of competition
        and, to a lesser extent, a shift by some U.S. dialysis customers to
        Aranesp.
    --  NEUPOGEN(®) (filgrastim) sales decreased 13 percent driven by the
        impact of competition in the U.S.
    --  Kyprolis sales increased 43 percent driven by higher unit demand.
    --  Vectibix(®) (panitumumab) sales increased 18 percent driven by higher
        unit demand.
    --  Nplate(®) (romiplostim) sales increased 12 percent driven by higher
        unit demand.
    --  BLINCYTO(®) (blinatumomab) sales increased 80 percent driven by higher
        unit demand.


    Product Sales Detail by Product and Geographic Region


                 $Millions, except percentages              Q1'16                     Q1'15        YOY  
                                                            -----                     -----        -----

                                                             US            ROW        TOTAL        TOTAL        TOTAL
                                                             ---           ---        -----        -----        -----


    Enbrel(R)                                                       $1,326        $59       $1,385       $1,116           24%

    Neulasta(R)                                                        996        187        1,183        1,134            4%

    Aranesp(R)                                                         261        271          532          480           11%

    XGEVA(R)                                                           271        107          378          340           11%

    Sensipar(R) / Mimpara(R)                                           278         89          367          334           10%

    Prolia(R)                                                          221        131          352          272           29%

    EPOGEN(R)                                                          300          0          300          534         (44%)

    NEUPOGEN(R)                                                        150         63          213          246         (13%)

    Kyprolis(R)                                                        129         25          154          108           43%

    Vectibix(R)                                                         56         88          144          122           18%

    Nplate(R)                                                           86         55          141          126           12%

    BLINCYTO(R)                                                         21          6           27           15           80%

    Repatha(R)                                                          14          2           16            0       *

    Other**                                                             10         37           47           47            0%
                                                                                 ---          ---          ---


    Total product sales                                             $4,119     $1,120       $5,239       $4,874            7%
                                                                    ======     ======       ======       ======           ===


    * Not meaningful

    ** Other includes MN Pharma, Bergamo, IMLYGIC(TM) and Corlanor(R)
    ----------------------------------------------------------------

Operating Expense, Operating Margin and Tax Rate Analysis, on an Adjusted Basis


    --  Cost of Sales margin improved by 1.6 percentage points driven by
        manufacturing efficiencies, higher net selling price and lower
        royalties.
    --  Research & Development (R&D) expenses were flat.
    --  Selling, General & Administrative (SG&A) expenses increased 11 percent
        driven by investments in new product launches.
    --  Operating Expenses increased 3 percent, with all expense categories
        reflecting savings from our transformation and process improvement
        efforts.
    --  Operating Margin improved by 4.4 percentage points to 54.6 percent.
    --  Tax Rate increased 1.9 percentage points due to changes in the
        geographic mix of earnings and the prior year benefit of a state tax
        audit settlement, offset partially by the benefit in the first quarter
        of 2016 of adopting the new Accounting Standard Update 2016-09,
        Improvements to Employee Share-Based Payment Accounting.


                     $Millions, except percentages

    On an Adjusted Basis                                        Q1'16                 Q1'15                       YOY  
                                                                -----                 -----                       -----


    Cost of Sales*                                                         $707                $735                     (4%)

                            % of sales          13.5%                           15.1%               (1.6) pts.

    Research & Development                                                $858                $856                       0%

                            % of sales          16.4%                           17.6%               (1.2) pts.

    Selling, General &
     Administrative                                                     $1,103                $993                      11%

                            % of sales          21.1%                           20.4%                0.7 pts.

    TOTAL Operating Expenses                                            $2,668              $2,584                       3%


    Operating Margin

                             operating
                             income as a
                             % of sales         54.6%                           50.2%                4.4 pts.


    Tax Rate*                                                            18.9%              17.0%              1.9 pts.


    pts: percentage points

                       *     Impact of Puerto Rico excise tax is included in
                             Cost of Sales and Tax Rate. Excluding Puerto
                             Rico excise tax, Cost of Sales would be 1.7
                             pts. and 1.9 pts. lower for 2016 and 2015,
                             respectively; and the Tax Rate would be 2.4
                             pts. and 2.8 pts. higher for 2016 and 2015,
                             respectively.
                     ---    -----------------------------------------------

Cash Flow and Balance Sheet


    --  The Company generated $1.8 billion of free cash flow in the first
        quarter of 2016 versus $1.4 billion in the first quarter of 2015 driven
        by higher revenues and higher operating income.
    --  The Company's second quarter 2016 dividend of $1.00 per share declared
        on March 2, 2016, will be paid on June 8, 2016, to all stockholders of
        record as of May 17, 2016.
    --  During the first quarter, the Company repurchased 4.7 million shares of
        common stock at a total cost of $690 million. At the end of the first
        quarter, the Company had $4.2 billion remaining under its stock
        repurchase authorization.


                   $Billions, except shares           Q1'16       Q1'15        YOY  
                                                      -----       -----        -----


    Operating Cash
     Flow                                                    $1.9         $1.5          $0.4

    Capital
     Expenditures                                             0.2          0.1           0.0

    Free Cash Flow                                         1.8          1.4           0.4

    Dividends Paid                                         0.8          0.6           0.2

    Share
     Repurchase                                            0.7          0.5           0.2

    Avg. Diluted
     Shares
     (millions)                                            760          770          (10)


    Cash and
     Investments                                          34.7         27.1           7.6

    Debt
     Outstanding                                          34.3         30.2           4.1

    Stockholders'
     Equity                                               28.7         26.5           2.2


                          Note: Numbers may not add due to
                          rounding
                          --------------------------------

2016 Guidance
For the full year 2016, the Company now expects:


    --  Total revenues in the range of $22.2 billion to $22.6 billion and
        adjusted EPS in the range of $10.85 to $11.20. Previously, the Company
        expected total revenues in the range of $22.0 billion to $22.5 billion
        and adjusted EPS in the range of $10.60 to $11.00.
    --  Adjusted tax rate in the range of 19 percent to 20 percent.
    --  Capital expenditures to be approximately $700 million.


    First Quarter Product and Pipeline Update

    Key 2016 development milestones:


    Clinical Program                                                Indication                                                      Milestone
    ----------------                                                ----------                                                      ---------

                       Repatha(R) (evolocumab)                                       Hyperlipidemia                 Phase 3 coronary imaging data expected H2

                                                                                                                    Phase 3 CV outcomes data expected H2*
    ---                                                             ---                                                             -------------------------------------

                              Kyprolis                                         Relapsed multiple myeloma                 EU regulatory review (ENDEAVOR)
                              --------                                         -------------------------                 ------------------------------

                    Parsabiv(TM) (etelcalcetide)**                            Secondary hyperparathyroidism                  Global regulatory reviews
                    ----------------------------                             -----------------------------                  -------------------------

                                XGEVA                                    Prevention of SREs in multiple myeloma             Phase 3 data expected H2*
                                -----                                    --------------------------------------             ------------------------

                               AMG 334                                            Migraine Prophylaxis          Phase 2b chronic migraine data expected mid-year

                                                                                                                 Phase 3 episodic migraine data expected H2
    ---                                                             ---                                                          ------------------------------------------

                               ABP 215                                                  Oncology                     Global regulatory submissions expected

                                              (biosimilar bevacizumab)
                       -----------------------                                                                                                                              ---

                               ABP 501                                           Inflammatory diseases                      Global regulatory reviews

                                              (biosimilar adalimumab)
                       ----------------------                                                                                                                               ---

                               ABP 980                                               Breast Cancer                          Phase 3 data expected H2

                                              (biosimilar trastuzumab)
                       -----------------------                                                                                                                              ---


    *Event driven study; **Trade name
     provisionally approved by FDA; CV =
     cardiovascular

The Company provided the following updates on selected product and pipeline programs:

Repatha


    --  In February, a Phase 3 study evaluating Repatha in patients with high
        cholesterol who cannot tolerate statins met the co-primary endpoints:
        the mean percent reductions from baseline in low-density lipoprotein
        cholesterol (LDL-C) at weeks 22 and 24, and the percent reduction from
        baseline in LDL-C at week 24.

BLINCYTO


    --  In March, a supplemental Biologics License Application (sBLA) was
        submitted to the U.S. Food and Drug Administration (FDA) for the
        treatment of pediatric and adolescent patients with Philadelphia
        chromosome-negative relapsed or refractory B-cell precursor acute
        lymphoblastic leukemia (ALL).
    --  In February, a Phase 3 open-label study evaluating the efficacy of
        BLINCYTO versus standard of care in adult patients with Philadelphia
        chromosome-negative relapsed or refractory B-cell precursor ALL met the
        primary endpoint of improved overall survival at a prespecified interim
        analysis.

IMLYGIC((TM) )(talimogene laherparepvec)


    --  In February, enrollment initiated for a Phase 3 study evaluating IMLYGIC
        in combination with KEYTRUDA(® )(pembrolizumab) in patients with
        unresectable metastatic melanoma.

XGEVA


    --  In March, enrollment completed for a Phase 3 event-driven study
        evaluating XGEVA compared with zoledronic acid for the prevention of
        skeletal-related events in patients with newly diagnosed multiple
        myeloma.  Data from the study are expected in H2 2016.

ENBREL


    --  In March, an sBLA for the treatment of pediatric patients with chronic
        severe plaque psoriasis was accepted for review by FDA.

Romosozumab


    --  In March, a Phase 3 study evaluating romosozumab in men with
        osteoporosis met the primary endpoint by increasing bone mineral density
        at the lumbar spine at 12 months.
    --  In February, a Phase 3 study evaluating romosozumab in postmenopausal
        women with osteoporosis met the co-primary endpoints by reducing the
        incidence of new vertebral fracture through months 12 and 24. The study
        also met a secondary endpoint by reducing the incidence of clinical
        fractures through 12 months.

AMG 334


    --  Data from a Phase 2b study in patients with chronic migraine are
        expected mid-year 2016.
    --  Data from two Phase 3 studies in patients with episodic migraine are
        expected in H2 2016.

Romosozumab is developed in collaboration with UCB globally, as well as Astellas in Japan
AMG 334 is developed in collaboration with Novartis
KEYTRUDA(®) is a registered trademark of Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc.

Non-GAAP Financial Measures
In this news release, management has presented its operating results for the first quarters of 2016 and 2015 in accordance with U.S. Generally Accepted Accounting Principles (GAAP) and on an adjusted (or non-GAAP) basis. In addition, management has presented its full year 2016 EPS and tax rate guidance in accordance with GAAP and on an adjusted (or non-GAAP) basis. These non-GAAP financial measures are computed by excluding certain items related to acquisitions, restructuring and certain other items from the related GAAP financial measures. Management has also presented Free Cash Flow (FCF), which is a non-GAAP financial measure, for the first quarters of 2016 and 2015. FCF is computed by subtracting capital expenditures from operating cash flow, each as determined in accordance with GAAP. Reconciliations for these non-GAAP financial measures to the most directly comparable GAAP financial measures are included in the news release.

The Company believes that its presentation of non-GAAP financial measures provides useful supplementary information to and facilitates additional analysis by investors. The Company uses certain non-GAAP financial measures to enhance an investor's overall understanding of the financial performance and prospects for the future of the Company's core business activities by facilitating comparisons of results of core business operations among current, past and future periods. In addition, the Company believes that excluding the non-cash amortization of intangible assets, including developed product technology rights, acquired in business combinations treats those assets as if the Company had developed them internally in the past, and thus provides a supplemental measure of profitability in which the Company's acquired intellectual property is treated in a comparable manner to its internally developed intellectual property. The Company believes that FCF provides a further measure of the Company's liquidity.

The Company uses the non-GAAP financial measures set forth in the news release in connection with its own budgeting and financial planning. The non-GAAP financial measures are in addition to, not a substitute for, or superior to, measures of financial performance prepared in accordance with GAAP.

About Amgen
Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology.

Amgen focuses on areas of high unmet medical need and leverages its biologics manufacturing expertise to strive for solutions that improve health outcomes and dramatically improve people's lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world's leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential.

For more information, visit www.amgen.com and follow us on www.twitter.com/amgen.

Forward-Looking Statements
This news release contains forward-looking statements that are based on the current expectations and beliefs of Amgen. All statements, other than statements of historical fact, are statements that could be deemed forward-looking statements, including estimates of revenues, operating margins, capital expenditures, cash, other financial metrics, expected legal, arbitration, political, regulatory or clinical results or practices, customer and prescriber patterns or practices, reimbursement activities and outcomes and other such estimates and results. Forward-looking statements involve significant risks and uncertainties, including those discussed below and more fully described in the Securities and Exchange Commission reports filed by Amgen, including our most recent annual report on Form 10-K and any subsequent periodic reports on Form 10-Q and Form 8-K. Unless otherwise noted, Amgen is providing this information as of the date of this news release and does not undertake any obligation to update any forward-looking statements contained in this document as a result of new information, future events or otherwise.

No forward-looking statement can be guaranteed and actual results may differ materially from those we project. Our results may be affected by our ability to successfully market both new and existing products domestically and internationally, clinical and regulatory developments involving current and future products, sales growth of recently launched products, competition from other products including biosimilars, difficulties or delays in manufacturing our products and global economic conditions. In addition, sales of our products are affected by pricing pressure, political and public scrutiny and reimbursement policies imposed by third-party payers, including governments, private insurance plans and managed care providers and may be affected by regulatory, clinical and guideline developments and domestic and international trends toward managed care and healthcare cost containment. Furthermore, our research, testing, pricing, marketing and other operations are subject to extensive regulation by domestic and foreign government regulatory authorities. We or others could identify safety, side effects or manufacturing problems with our products after they are on the market. Our business may be impacted by government investigations, litigation and product liability claims. In addition, our business may be impacted by the adoption of new tax legislation or exposure to additional tax liabilities. If we fail to meet the compliance obligations in the corporate integrity agreement between us and the U.S. government, we could become subject to significant sanctions. Further, while we routinely obtain patents for our products and technology, the protection offered by our patents and patent applications may be challenged, invalidated or circumvented by our competitors, or we may fail to prevail in present and future intellectual property litigation. We perform a substantial amount of our commercial manufacturing activities at a few key facilities and also depend on third parties for a portion of our manufacturing activities, and limits on supply may constrain sales of certain of our current products and product candidate development. In addition, we compete with other companies with respect to many of our marketed products as well as for the discovery and development of new products. Discovery or identification of new product candidates cannot be guaranteed and movement from concept to product is uncertain; consequently, there can be no guarantee that any particular product candidate will be successful and become a commercial product. Further, some raw materials, medical devices and component parts for our products are supplied by sole third-party suppliers. The discovery of significant problems with a product similar to one of our products that implicate an entire class of products could have a material adverse effect on sales of the affected products and on our business and results of operations. Our efforts to acquire other companies or products and to integrate the operations of companies we have acquired may not be successful. We may not be able to access the capital and credit markets on terms that are favorable to us, or at all. We are increasingly dependent on information technology systems, infrastructure and data security. Our stock price is volatile and may be affected by a number of events. Our business performance could affect or limit the ability of our Board of Directors to declare a dividend or our ability to pay a dividend or repurchase our common stock.



    Amgen Inc.

    Consolidated Statements of Income - GAAP

    (In millions, except per share data)

    (Unaudited)


                                              Three months ended

                                                   March 31,
                                                   ---------

                                                              2016      2015
                                                              ----      ----

    Revenues:

                     Product sales                          $5,239    $4,874

                      Other
                      revenues                                 288       159


                     Total revenues                          5,527     5,033
                                                             -----     -----


    Operating expenses:

                     Cost of sales                           1,018     1,033

                      Research and
                      development                              872       894

                      Selling,
                      general and
                      administrative                         1,203     1,026

                     Other                                      32        58

                     Total operating expenses                3,125     3,011
                                                             -----     -----


    Operating income                                      2,402     2,022


    Interest expense, net                                   294       252

    Interest and other income, net                          150       106
                                                            ---       ---


    Income before income taxes                            2,258     1,876


    Provision for income taxes                              358       253


    Net income                                           $1,900    $1,623
                                                         ======    ======


    Earnings per share:

                     Basic                                   $2.52     $2.13

                     Diluted                                 $2.50     $2.11


    Weighted average shares used in
     calculation of earnings per share:

                     Basic                                     753       761

                     Diluted                                   760       770


    Amgen Inc.

    Consolidated Balance Sheets - GAAP

    (In millions)

    (Unaudited)


                                     March 31,          December 31,

                                                2016                  2015
                                                ----                  ----

    Assets

    Current
     assets:

                      Cash, cash
                       equivalents
                       and
                       marketable
                       securities              $34,740               $31,382

                       Trade
                       receivables,
                       net                                   3,078           2,995

                      Inventories                            2,572           2,435

                       Other current
                       assets                                1,816           1,703


                       Total
                       current
                       assets                   42,206                38,515

    Property,
     plant and
     equipment,
     net                     4,885                4,907

    Intangible
     assets, net            11,448               11,641

    Goodwill                14,804               14,787

    Other assets             1,773                1,599
                             -----                -----

    Total assets           $75,116              $71,449
                           =======              =======


    Liabilities
     and
     Stockholders'
     Equity

    Current
     liabilities:

                       Accounts
                       payable and
                       accrued
                       liabilities              $6,276                $6,417

                       Current
                       portion of
                       long-term
                       debt                                  2,247           2,247

                       Total
                       current
                       liabilities               8,523                 8,664

    Long-term
     debt                   32,060               29,182

    Long-term
     deferred
     tax
     liability               2,202                2,239

    Other
     noncurrent
     liabilities             3,649                3,281

     Stockholders'
     equity                 28,682               28,083
                            ------               ------

    Total
     liabilities
     and
     stockholders'
     equity                $75,116              $71,449
                           =======              =======


    Shares
     outstanding               751                  754


    Amgen Inc.

    GAAP to Adjusted Reconciliations

    (In millions)

    (Unaudited)



                                                                     Three months ended

                                                                        March 31,
                                                                        ---------

                                                                         2016           2015
                                                                         ----           ----


                 GAAP cost of sales                                      $1,018         $1,033

                 Adjustments to cost of sales:

                 Acquisition-related expenses (a)                         (311)         (284)

                  Certain net charges pursuant to our restructuring
                  initiative                                                  -          (14)

                 Total adjustments to cost of sales                       (311)         (298)

                 Adjusted cost of sales                                    $707           $735
                 ======================



                 GAAP research and development expenses                    $872           $894

                 Adjustments to research and development expenses:

                 Acquisition-related expenses (a)                          (19)          (21)

                  Certain net charges pursuant to our restructuring
                  initiative                                                  5           (17)

                  Total adjustments to research and development
                  expenses                                                 (14)          (38)

                 Adjusted research and development expenses                $858           $856
                 ======================



                 GAAP selling, general and administrative expenses       $1,203         $1,026

                  Adjustments to selling, general and administrative
                  expenses:

                 Acquisition-related expenses (b)                         (101)          (29)

                  Certain net charges pursuant to our restructuring
                  initiative                                                  1            (4)

                  Total adjustments to selling, general and
                  administrative expenses                                 (100)          (33)

                  Adjusted selling, general and administrative
                  expenses                                               $1,103           $993
                                                                       ======



                 GAAP operating expenses                                 $3,125         $3,011

                 Adjustments to operating expenses:

                 Adjustments to cost of sales                             (311)         (298)

                 Adjustments to research and development expenses          (14)          (38)

                  Adjustments to selling, general and administrative
                  expenses                                                (100)          (33)

                  Certain net charges pursuant to our restructuring
                  initiative (c)                                            (2)          (57)

                 Expense related to a legal proceeding                     (27)             -

                 Other                                                      (3)           (1)

                 Total adjustments to operating expenses                  (457)         (427)

                 Adjusted operating expenses                             $2,668         $2,584
                                                                       ======



                 GAAP operating income                                   $2,402         $2,022

                 Adjustments to operating expenses                          457            427

                 Adjusted operating income                               $2,859         $2,449
                                                                       ======



                 GAAP income before income taxes                         $2,258         $1,876

                 Adjustments to operating expenses                          457            427

                 Adjusted income before income taxes                     $2,715         $2,303
                                                                       ======



                 GAAP provision for income taxes                           $358           $253

                 Adjustments to provision for income taxes:

                 Income tax effect of the above adjustments (d)             139            139

                 Other income tax adjustments (e)                            15              -

                 Total adjustments to provision for income taxes            154            139

                 Adjusted provision for income taxes                       $512           $392
                 ======================



                 GAAP net income                                         $1,900         $1,623

                 Adjustments to net income:

                  Adjustments to income before income taxes, net of
                  the income tax effect of the above adjustments            318            288

                 Other income tax adjustments (e)                          (15)             -

                 Total adjustments to net income                            303            288

                 Adjusted net income                                     $2,203         $1,911
                                                                       ======


    Amgen Inc.

    GAAP to Adjusted Reconciliations

    (In millions, except per share data)

    (Unaudited)



               The following table presents the computations for GAAP
               and Adjusted diluted EPS.


                                          Three months ended                 Three months ended

                                            March 31, 2016                    March 31, 2015
                                            --------------                    --------------

                          GAAP                         Adjusted               GAAP               Adjusted
                          ----                         --------               ----               --------


              Net income                      $1,900                  $2,203              $1,623          $1,911

               Weighted-average shares
               for diluted EPS                   760                     760                 770             770

              Diluted EPS                      $2.50                   $2.90               $2.11           $2.48
              ===========


             (a)     The
                     adjustments
                     related
                     primarily to
                     non-cash
                     amortization
                     of intangible
                     assets
                     acquired in
                     business
                     combinations.


             (b)     The 2016
                     adjustments
                     related
                     primarily to
                     a $73-
                     million
                     charge
                     resulting
                     from the
                     reacquisition
                     of Prolia(R),
                     XGEVA(R) and
                     Vectibix(R)
                     license
                     agreements in
                     certain
                     markets from
                     Glaxo Group
                     Limited, as
                     well as non-
                     cash
                     amortization
                     of intangible
                     assets
                     acquired in
                     business
                     combinations.
                      The 2015
                      adjustments
                     related
                     primarily to
                     non-cash
                     amortization
                     of intangible
                     assets
                     acquired in
                     business
                     combinations.


             (c)     The 2015
                     adjustments
                     related
                     primarily to
                     severance
                     expenses.


             (d)     The tax effect
                     of the
                     adjustments
                     between our
                     GAAP and
                     Adjusted
                     results takes
                     into account
                     the tax
                     treatment and
                     related tax
                     rate(s) that
                     apply to each
                     adjustment in
                     the
                     applicable
                     tax
                     jurisdiction(s).
                     Generally,
                     this results
                     in a tax
                     impact at the
                     U.S. marginal
                     tax rate for
                     certain
                     adjustments,
                     including the
                     majority of
                     amortization
                     of intangible
                     assets,
                     whereas the
                     tax impact of
                     other
                     adjustments,
                     including
                     restructuring
                     expense,
                     depends on
                     whether the
                     amounts are
                     deductible in
                     the
                     respective
                     tax
                     jurisdictions
                     and the
                     applicable
                     tax rate(s)
                     in those
                     jurisdictions.
                     Due to these
                     factors, the
                     effective tax
                     rates for the
                     adjustments
                     to our GAAP
                     income before
                     income taxes,
                     for the three
                     months ended
                     March 31,
                     2016 and
                     2015, were
                     30.4% and
                     32.6%,
                     respectively.


             (e)     The
                     adjustments
                     related to
                     certain prior
                     period items
                     excluded from
                     adjusted
                     earnings.


    Amgen Inc.

    Reconciliations of Free Cash Flow

    (In millions)

    (Unaudited)


                                               Three months ended

                                                    March 31,
                                                    ---------

                                                                2016            2015
                                                                ----            ----

                           Operating
                           Cash Flow    $1,915                       $1,482 (a)

                           Capital
                           Expenditures  (156)                       (118)

                           Free Cash
                           Flow         $1,759                       $1,364
                          ==========


              (a)
               Restated
               to include
               $153
               million,
               which was
               previously
               included
               in cash
               flows from
               financing
               activities,
               as a
               result of
               the
               adoption
               of
               Accounting
               Standard
               Update
               2016-09.


    Amgen Inc.

    Reconciliation of GAAP EPS Guidance to Adjusted

    EPS Guidance for the Year Ending December 31, 2016

    (Unaudited)




                                                                                     2016
                                                                                     ----


    GAAP diluted EPS guidance                                                    $9.34       -     $9.74


    Known adjustments to arrive at
     Adjusted earnings*:

                              Acquisition-related expenses             (a)           1.37

                              Restructuring charges                                  0.09       -      0.14

                              Legal proceeding charge                                       0.02

                              Tax adjustments                          (b)                (0.02)



    Adjusted diluted EPS guidance                                               $10.85       -    $11.20
                                                                                ======     ===    ======


                         *     The known adjustments are presented net of their
                               related tax impact which amount to
                               approximately $0.68 to $0.70 per share, in the
                               aggregate.


                       (a)     The adjustments relate primarily to non-cash
                               amortization of intangible assets acquired in
                               prior year business combinations.


                       (b)     The adjustments relate to certain prior period
                               items excluded from adjusted earnings.





    Reconciliation of GAAP Tax Rate Guidance to Adjusted

    Tax Rate Guidance for the Year Ending December 31, 2016

    (Unaudited)



                                                                                     2016
                                                                                     ----


    GAAP tax rate guidance                                                       16.5%      -     17.5%


                               Tax rate effect
                               of known
                               adjustments
                               discussed above                                              2.5%



    Adjusted tax rate guidance                                                   19.0%      -     20.0%
                                                                                  ====     ===      ====

CONTACT: Amgen, Thousand Oaks
Trish Hawkins, 805-447-5631 (media)
Arvind Sood, 805-447-1060 (investors)

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SOURCE Amgen