After spending the majority of the session in flat to slightly positive territory, British blue chips turned lower, in step with the broader equity market after reports about a leaked memo by former FBI chief James Comey brought political worries into focus.
The blue chip FTSE 100 <.FTSE> index was down 0.25 percent at 7,503.47 points at its close, sliding from a record high hit in the previous session, though the FTSE's fall was tempered by strength among energy stocks and precious metals miners.
"The political uncertainty in (Washington) DC has given traders the perfect excuse to bank the previous day's profits," David Madden, market analyst at CMC Markets UK, said.
"London's relatively high exposure to commodity related companies has ensured that the sell-off hasn’t been that severe."
Shares in CRH <CRH.L> and Ashtead (>> Ashtead Group plc) were among the biggest fallers, while results weighed on British Land (>> British Land Company PLC), which fell 3.3 percent - its biggest one-day loss in four months - after issuing a cautious outlook for the property market due to Brexit uncertainty.
Peers Land Securities Group (>> Land Securities Group plc) and Intu Properties (>> Intu Properties PLC) also fell.
Among miners, Glencore (>> Glencore PLC) and Anglo American (>> Anglo American plc) were down 2.2 percent and 1.1 percent respectively.
There were a few bright spots, however, with banking stock Lloyds (>> Lloyds Banking Group PLC) rising 2 percent after the British government sold off its remaining stake in the lender following its bailout in the 2007-09 global financial crisis.
Investment platform provider Hargreaves Lansdown (>> Hargreaves Lansdown PLC) was also a top gainer, up 1.7 percent and recovering some of its losses from the previous session.
Its shares tumbled 8.5 percent on Tuesday, with traders pointing to an announcement from ETF provider Vanguard about plans to sell directly to investors in Europe for the first time.
"The HL business model has proved itself to be incredibly resilient in the face of a couple of major headwinds in recent years," Shore Capital analyst Paul McGinnis said in a note.
"We would be a lot more nervous around the implications of the Vanguard platform for the fledgling robo-advice sector."
Precious metals miner Randgold Resources (>> Randgold Resources Limited) was also in demand as the price of gold rose. [GOL]
Broker action lifted shares in Kingfisher (>> Kingfisher plc), which was up 2 percent after HSBC raised its recommendation on the stock to "buy" from "hold".
A Jefferies downgrade to "underperform" from "buy" weighed on pharma stock Hikma (>> Hikma Pharmaceuticals Plc), which dropped 2.8 percent.
Jefferies equity analyst James Vane-Tempest cited the recent delay in U.S. approval for Hikma's generic drug Advair.
Outside of the blue chips, well-received full-year results from Sophos (>> Sophos Ltd) helped the network security firm hit a new lifetime high, up 6.9 percent.
The stock has been in demand following a global "ransomware" attack, boosting shares in cyber security firms.
(Editing by Andrew Heavens and Ed Osmond)
By Kit Rees
Stocks treated in this article : Lloyds Banking Group PLC
, Ashtead Group plc
, Intu Properties PLC
, Hargreaves Lansdown PLC
, Anglo American plc
, Glencore PLC
, British Land Company PLC
, Kingfisher plc
, Land Securities Group plc
, Randgold Resources Limited
, Hikma Pharmaceuticals Plc
, Sophos Ltd