Breakthrough technology for skin anti-aging targets telomere stability and longevity

BARCELONA, Spain - Addressing skin cell integrity, Ashland Specialty Ingredients, a commercial unit of Ashland Inc., today introduced Telosense™ biofunctional for anti-aging skin care applications. The special complex of hydrolyzed yeast and soya proteins is designed to help preserve telomeres, which cap and protect cell chromosomes. Research has shown that telomeres, a repeating sequence of nucleotides measuring thousands of base pairs in length, play an important role in cell division as they help preserve DNA information. As aging occurs, however, telomeres shorten with each cell division, losing dozens of base pairs per year. Telosense biofunctional addresses telomere shortening by boosting in vitro / ex vivo the expression of Telomeric Repeat Factor 2 (TRF2) proteins. The ingredient will find application primarily in skin care formulations aimed at enhancing the appearance of skin.

According to Joel Mantelin, global marketing director, Skin Care, Care Specialties, Ashland Specialty Ingredients, this breakthrough approach to helping consumers achieve younger-looking skin taps into the cutting-edge area of skin care research. "Targeting proteins that have fundamental roles in the stability and protection of chromosome ends, Telosense biofunctional is unlike any other ingredient on the market," he said. "With the commercial launch of Telosense biofunctional, anti-aging skin care formulators may now target cell integrity in support of beautiful skin."

Skin care inside and out
A double-blind clinical study against a placebo was conducted to evaluate the visible effects of Telosense biofunctional on skin hydration and the appearance of wrinkles. A panel of 15 women ages 33 to 53 was studied following the application of a placebo and a formulation containing Telosense biofunctional at 1 percent around their crows-feet area twice a day for 56 days. Software measurement of wrinkle parameters on silicon replicas was used to determine the outcome.

Mantelin said the study results demonstrate that Telosense biofunctional visibly reduced the signs of skin aging. "Applying Telosense biofunctional at 1 percent in a cosmetic formula limited the appearance of aged skin and reduced the appearance of wrinkles," he said. "Addressing anti-aging at the cellular level may ultimately be proven as the most effective and efficient skin care strategy."

Biomarkers confirm visual observations
Using biomarker intensity as an indicator of Telosense biofunctional's effectiveness, a range of scientific experiments confirmed its efficacy. The most widely used biomarker for senescent and aged cells is senescence-associated

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