LONDON--(BUSINESS WIRE)--

FORM 8.3 - AMENDMENT TO PURCHASES

PUBLIC OPENING POSITION DISCLOSURE/DEALING DISCLOSURE BY

A PERSON WITH INTERESTS IN RELEVANT SECURITIES REPRESENTING 1% OR MORE

Rule 8.3 of the Takeover Code (the 'Code')

1. KEY INFORMATION

(a) Full name of discloser: Barclays PLC.
(b) Owner or controller of interest and short
positions disclosed, if different from 1(a):
(c) Name of offeror/offeree in relation to whose SHIRE PLC
relevant securities this form relates:
(d) If an exempt fund manager connected with an
offeror/offeree, state this and specify identity of
offeror/offeree:
(e) Date position held/dealing undertaken: 19 June 2018
(f) In addition to the company in 1(c) above, is the discloser making YES:
disclosures in respect of any other party to the offer? TAKEDA PHARMACEUTICAL CO LTD

2. POSITIONS OF THE PERSON MAKING THE DISCLOSURE

If there are positions or rights to subscribe to disclose in more than one class of relevant securities of the offeror or offeree named in 1(c), copy table 2(a) or (b) (as appropriate) for each additional class of relevant security.

(a) Interests and short positions in the relevant securities of the offeror or offeree to which the disclosure relates following the dealing (if any)

Class of relevant security: 5p ordinary
Interests Short Positions
Number (%) Number (%)
(1) Relevant securities owned
and/or controlled: 8,595,862 0.94% 4,140,555 0.45%
(2) Cash-settled derivatives:
161,602 0.02% 4,650,655 0.51%
(3) Stock-settled derivatives (including options)
and agreements to purchase/sell: 242,400 0.03% 255,500 0.03%
TOTAL: 8,999,864 0.98% 9,046,710 0.99%

All interests and all short positions should be disclosed.

Details of any open stock-settled derivative positions (including traded options), or agreements to purchase or sell relevant securities, should be given on a Supplemental Form 8 (Open Positions).

(b) Rights to subscribe for new securities (including directors' and other employee options)

Class of relevant security in relation to which subscription right exists:
Details, including nature of the rights concerned and relevant percentages:

3. DEALINGS (IF ANY) BY THE PERSON MAKING THE DISCLOSURE

Where there have been dealings in more than one class of relevant securities of the offeror or offeree named in 1(c), copy table 3(a), (b), (c) or (d) (as appropriate) for each additional class of relevant security dealt in.

The currency of all prices and other monetary amounts should be stated.

(a) Purchases and sales

Class of relevant Purchase/sale Number of Price per unit
security securities
ADR Purchase 22 157.3500 USD
ADR Purchase 40 157.6697 USD
ADR Purchase 75 157.6701 USD
ADR Purchase 89 157.2200 USD
5p ordinary Purchase 91 39.8000 GBP
ADR Purchase 100 157.8175 USD
ADR Purchase 100 157.3400 USD
5p ordinary Purchase 100 39.7650 GBP
ADR Purchase 100 158.0000 USD
ADR Purchase 100 157.6800 USD
5p ordinary Purchase 182 39.5700 GBP
5p ordinary Purchase 187 39.7525 GBP
ADR Purchase 200 157.5400 USD
ADR Purchase 200 157.7160 USD
5p ordinary Purchase 238 39.8094 GBP
5p ordinary Purchase 276 39.6742 GBP
ADR Purchase 300 157.6750 USD
5p ordinary Purchase 306 39.7839 GBP
5p ordinary Purchase 349 39.7671 GBP
5p ordinary Purchase 385 39.7156 GBP
5p ordinary Purchase 401 39.6094 GBP
5p ordinary Purchase 437 39.7678 GBP
ADR Purchase 476 157.8014 USD
ADR Purchase 500 157.7080 USD
ADR Purchase 514 157.0663 USD
ADR Purchase 561 156.9272 USD
5p ordinary Purchase 1,239 39.8032 GBP
5p ordinary Purchase 1,313 39.5892 GBP
ADR Purchase 1,400 157.4182 USD
ADR Purchase 1,939 157.5811 USD
5p ordinary Purchase 2,181 39.6896 GBP
5p ordinary Purchase 2,281 39.5737 GBP
ADR Purchase 2,322 156.9800 USD
5p ordinary Purchase 2,605 39.5604 GBP
5p ordinary Purchase 4,009 39.9235 GBP
ADR Purchase 4,028 157.6207 USD
ADR Purchase 4,300 157.6780 USD
ADR Purchase 4,400 157.6734 USD
5p ordinary Purchase 5,156 39.6283 GBP
5p ordinary Purchase 5,473 39.7728 GBP
ADR Purchase 5,927 157.6330 USD
5p ordinary Purchase 9,216 39.5985 GBP
5p ordinary Purchase 10,848 39.6108 GBP
5p ordinary Purchase 14,559 39.7400 GBP
5p ordinary Purchase 17,267 39.7750 GBP
5p ordinary Purchase 24,174 39.7153 GBP
5p ordinary Purchase 25,967 39.6917 GBP
5p ordinary Purchase 34,535 39.9600 GBP
ADR Purchase 40,718 157.6761 USD
5p ordinary Purchase 44,895 39.9131 GBP
5p ordinary Purchase 51,802 39.5600 GBP
5p ordinary Purchase 53,673 39.7868 GBP
5p ordinary Purchase 64,998 39.7793 GBP
5p ordinary Purchase 84,783 39.7466 GBP
5p ordinary Purchase 69,070 39.9498 GBP
5p ordinary Purchase 189,945 39.7354 GBP
5p ordinary Sale 7 39.5775 GBP
5p ordinary Sale 16 39.6125 GBP
ADR Sale 22 157.3500 USD
5p ordinary Sale 25 39.5750 GBP
5p ordinary Sale 40 39.5600 GBP
ADR Sale 40 157.6697 USD
5p ordinary Sale 63 39.9017 GBP
ADR Sale 75 157.6701 USD
ADR Sale 89 157.2200 USD
5p ordinary Sale 89 39.5220 GBP
ADR Sale 100 157.4500 USD
ADR Sale 100 158.0000 USD
5p ordinary Sale 187 39.7525 GBP
ADR Sale 200 157.8800 USD
5p ordinary Sale 238 39.8134 GBP
5p ordinary Sale 257 39.5833 GBP
5p ordinary Sale 280 39.6234 GBP
ADR Sale 300 157.6825 USD
ADR Sale 300 158.0033 USD
5p ordinary Sale 328 39.5587 GBP
ADR Sale 338 157.7622 USD
ADR Sale 400 157.4975 USD
5p ordinary Sale 440 39.7383 GBP
ADR Sale 514 157.0663 USD
5p ordinary Sale 514 39.8817 GBP
5p ordinary Sale 565 39.6191 GBP
ADR Sale 600 157.5116 USD
ADR Sale 600 157.4183 USD
ADR Sale 676 157.7761 USD
5p ordinary Sale 1,068 39.6536 GBP
ADR Sale 1,399 157.5619 USD
ADR Sale 1,400 157.4614 USD
5p ordinary Sale 1,469 39.5729 GBP
ADR Sale 1,614 156.9800 USD
ADR Sale 1,815 157.1105 USD
ADR Sale 1,900 157.6663 USD
5p ordinary Sale 1,978 39.5785 GBP
5p ordinary Sale 2,102 39.8553 GBP
ADR Sale 2,900 157.7826 USD
ADR Sale 3,028 157.6730 USD
ADR Sale 3,700 157.7059 USD
5p ordinary Sale 6,551 39.7396 GBP
5p ordinary Sale 9,967 39.7741 GBP
5p ordinary Sale 16,428 39.7818 GBP
5p ordinary Sale 16,531 39.6135 GBP
5p ordinary Sale 19,435 39.5856 GBP
5p ordinary Sale 26,552 39.7800 GBP
5p ordinary Sale 33,210 39.6725 GBP
5p ordinary Sale 43,412 39.6810 GBP
ADR Sale 45,946 157.6579 USD
5p ordinary Sale 52,479 39.7876 GBP
5p ordinary Sale 61,667 39.7817 GBP
5p ordinary Sale 73,790 39.7426 GBP
5p ordinary Sale 147,014 39.7413 GBP

(b) Cash-settled derivative transactions

Class of Product Nature of dealing Number of Price per
relevant description reference unit
security securities
5p ordinary CFD Long 63 39.9019 GBP
5p ordinary SWAP Long 151 39.9496 GBP
5p ordinary SWAP Long 260 39.6746 GBP
5p ordinary CFD Long 280 39.6234 GBP
5p ordinary CFD Long 514 39.8817 GBP
5p ordinary SWAP Long 2,039 39.6121 GBP
5p ordinary CFD Long 2,102 39.8552 GBP
5p ordinary CFD Long 6,014 39.5672 GBP
5p ordinary SWAP Long 11,388 39.7813 GBP
5p ordinary SWAP Long 32,081 39.6050 GBP
5p ordinary SWAP Long 32,787 39.7800 GBP
5p ordinary CFD Long 33,210 39.6725 GBP
5p ordinary SWAP Short 3 39.7833 GBP
5p ordinary SWAP Short 73 39.9500 GBP
5p ordinary SWAP Short 236 39.8817 GBP
5p ordinary SWAP Short 420 39.6800 GBP
5p ordinary SWAP Short 603 39.7906 GBP
5p ordinary SWAP Short 917 39.6509 GBP
5p ordinary SWAP Short 2,037 39.7780 GBP
5p ordinary SWAP Short 2,367 39.8621 GBP
5p ordinary SWAP Short 3,379 39.5995 GBP
5p ordinary CFD Short 4,009 39.9235 GBP
5p ordinary CFD Short 5,397 39.8209 GBP
5p ordinary CFD Short 5,473 39.7728 GBP
5p ordinary CFD Short 8,758 39.9677 GBP
5p ordinary CFD Short 9,216 39.5985 GBP
5p ordinary CFD Short 10,848 39.6108 GBP
5p ordinary SWAP Short 14,313 39.6045 GBP
5p ordinary SWAP Short 24,489 39.7021 GBP

(c) Stock-settled derivative transactions (including options)

(i) Writing, selling, purchasing or varying

Class Product Writing, Number Exercise Type Expiry Option
of description purchasing, of price date money
relevant selling, securities per unit paid/
security varying etc to which received
option per unit
relates
ADR Call Options Purchasing 1,000 150 USD American 20 Jul 2018 9.6500 USD
ADR Call Options Selling 1,000 145 USD American 20 Jul 2018 13.9500 USD
ADR Call Options Selling 200 165 USD American 29 Jun 2018 0.4800 USD
ADR Call Options Selling 1,300 168 USD American 22 Jun 2018 0.1000 USD
ADR Call Options Selling 1,000 170 USD American 22 Jun 2018 0.0400 USD
ADR Put Options Purchasing 200 150 USD American 20 Jul 2018 1.8500 USD
ADR Put Options Selling 200 145 USD American 20 Jul 2018 1.1500 USD
ADR Put Options Selling 200 153 USD American 22 Jun 2018 0.4500 USD

(ii) Exercise

Class of relevant security Product description

e.g. call option

Exercising/ exercised against Number of securities Exercise price per unit

(d) Other dealings (including subscribing for new securities)

Class of relevant security Nature of dealing

e.g. subscription, conversion

Details Price per unit (if applicable)

4. OTHER INFORMATION

(a) Indemnity and other dealing arrangements

Details of any indemnity or option arrangement, or any agreement or understanding, formal or informal, relating to relevant securities which may be an inducement to deal or refrain from dealing entered into by the person making the disclosure and any party to the offer or any person acting in concert with a party to the offer:

Irrevocable commitments and letters of intent should not be included. If there are no such agreements, arrangements or understandings, state 'none'

None

(b) Agreements, arrangements or understandings relating to options or derivatives

Details of any agreement, arrangement or understanding, formal or informal, between the person making the disclosure and any other person relating to:

(i) the voting rights of any relevant securities under any option; or

(ii) the voting rights or future acquisition or disposal of any relevant securities to which any derivative is referenced:

If there are no such agreements, arrangements or understandings, state 'none'

None

(c) Attachments

Is a Supplemental Form 8 (Open Positions) attached? YES
Date of disclosure: 21 Jun 2018
Contact name: Femi Badmos
Telephone number: 020 3555 1125

Public disclosures under Rule 8 of the Code must be made to a Regulatory Information Service.

The Panel's Market Surveillance Unit is available for consultation in relation to the Code's disclosure requirements on +44 (0)20 7638 0129.

The Code can be viewed on the Panel's website atwww.thetakeoverpanel.org.uk.

SUPPLEMENTAL FORM 8 (OPEN POSITIONS)

DETAILS OF OPEN STOCK-SETTLED DERIVATIVE (INCLUDING OPTION) POSITIONS, AGREEMENTS TO PURCHASE OR SELL ETC.

Note 5(i) on Rule 8 of the Takeover Code (the 'Code')

1. KEY INFORMATION

Identity of the person whose positions/dealings Barclays PLC.
are being disclosed:
Name of offeror/offeree in relation to whose SHIRE PLC
relevant securities this from relates:

2. STOCK-SETTLED DERIVATIVES (INCLUDING OPTIONS)

Class Product Writing, Number Exercise Type Expiry
of description purchasing, of price date
relevant selling, securities per unit
security varying etc to which
option
relates
5p ordinary Call Options Written -125,000 3600.0000 American 21 Dec 2018
ADR Call Options Purchased 20,700 175.0000 American 20 Jul 2018
ADR Put Options Written 2,100 140.0000 American 20 Jul 2018
ADR Call Options Purchased 1,700 195.0000 American 17 Jan 2020
ADR Call Options Purchased 1,000 180.0000 American 17 Jan 2020
ADR Call Options Purchased 1,000 170.0000 American 17 Jan 2020
ADR Call Options Purchased 200 135.0000 American 17 Jan 2020
ADR Put Options Written 200 153.0000 American 22 Jun 2018
ADR Call Options Purchased 100 175.0000 American 18 Jan 2019
ADR Put Options Written 100 110.0000 American 17 Jan 2020
ADR Put Options Purchased -400 165.0000 American 17 Jan 2020
ADR Put Options Purchased -700 160.0000 American 17 Jan 2020
ADR Put Options Purchased -1,000 150.0000 American 18 Jan 2019
ADR Put Options Purchased -1,500 165.0000 American 18 Jan 2019
ADR Put Options Purchased -2,600 160.0000 American 20 Jul 2018
ADR Put Options Purchased -2,700 80.0000 American 18 Jan 2019
ADR Put Options Purchased -5,800 180.0000 American 18 Jan 2019
ADR Put Options Purchased -7,700 130.0000 American 18 Jan 2019
ADR Put Options Purchased -44,000 145.0000 American 19 Oct 2018
ADR Call Options Purchased 1,600 170.0000 American 19 Oct 2018
ADR Put Options Purchased -100 158.0000 American 22 Jun 2018
ADR Call Options Written -100 125.0000 American 20 Jul 2018
ADR Put Options Written 21,700 155.0000 American 20 Jul 2018
ADR Call Options Purchased 14,900 168.0000 American 29 Jun 2018
ADR Call Options Purchased 3,600 185.0000 American 19 Oct 2018
ADR Call Options Purchased 3,100 155.0000 American 18 Jan 2019
ADR Put Options Written 2,900 95.0000 American 20 Jul 2018
ADR Put Options Written 1,000 90.0000 American 18 Jan 2019
ADR Call Options Purchased 700 150.0000 American 20 Jul 2018
ADR Call Options Purchased 600 125.0000 American 18 Jan 2019
ADR Call Options Purchased 400 230.0000 American 18 Jan 2019
ADR Call Options Purchased 300 115.0000 American 18 Jan 2019
ADR Put Options Written 200 200.0000 American 17 Jan 2020
ADR Put Options Written 200 125.0000 American 19 Oct 2018
ADR Put Options Written 200 135.0000 American 20 Jul 2018
ADR Call Options Purchased 100 220.0000 American 18 Jan 2019
ADR Put Options Written 100 95.0000 American 18 Jan 2019
ADR Put Options Purchased -100 120.0000 American 20 Jul 2018
ADR Call Options Written -100 140.0000 American 17 Jan 2020
ADR Call Options Written -400 173.0000 American 22 Jun 2018
ADR Call Options Written -1,000 85.0000 American 18 Jan 2019
ADR Call Options Written -1,600 145.0000 American 18 Jan 2019
ADR Call Options Written -1,900 145.0000 American 20 Jul 2018
ADR Put Options Purchased -2,200 110.0000 American 20 Jul 2018
ADR Put Options Purchased -2,500 120.0000 American 17 Jan 2020
ADR Call Options Purchased 4,500 200.0000 American 18 Jan 2019
ADR Call Options Purchased 2,300 165.0000 American 20 Jul 2018
ADR Call Options Purchased 200 155.0000 American 17 Jan 2020
ADR Call Options Purchased 200 130.0000 American 17 Jan 2020
ADR Put Options Purchased -200 170.0000 American 18 Jan 2019
ADR Call Options Written -400 115.0000 American 20 Jul 2018
ADR Call Options Written -600 175.0000 American 19 Oct 2018
ADR Put Options Purchased -800 150.0000 American 17 Jan 2020
ADR Call Options Written -1,500 148.0000 American 22 Jun 2018
ADR Call Options Purchased 2,200 185.0000 American 18 Jan 2019
ADR Call Options Purchased 500 195.0000 American 18 Jan 2019
ADR Put Options Written 500 125.0000 American 20 Jul 2018
ADR Call Options Purchased 400 165.0000 American 18 Jan 2019
ADR Call Options Purchased 200 120.0000 American 17 Jan 2020
ADR Put Options Purchased -200 115.0000 American 19 Oct 2018
ADR Put Options Purchased -1,000 105.0000 American 18 Jan 2019
ADR Put Options Purchased -1,200 115.0000 American 20 Jul 2018
ADR Call Options Written -1,300 168.0000 American 22 Jun 2018
ADR Call Options Written -3,400 170.0000 American 22 Jun 2018
ADR Call Options Written -8,000 180.0000 American 18 Jan 2019
ADR Call Options Purchased 1,500 140.0000 American 20 Jul 2018
ADR Call Options Purchased 1,100 170.0000 American 18 Jan 2019
ADR Call Options Purchased 200 160.0000 American 17 Jan 2020
ADR Call Options Written -100 130.0000 American 18 Jan 2019
ADR Put Options Purchased -300 150.0000 American 20 Jul 2018
ADR Put Options Purchased -500 140.0000 American 17 Jan 2020
ADR Call Options Written -700 170.0000 American 20 Jul 2018
ADR Put Options Purchased -1,000 80.0000 American 17 Jan 2020
ADR Put Options Purchased -2,300 85.0000 American 18 Jan 2019
ADR Put Options Purchased -6,000 135.0000 American 18 Jan 2019
ADR Put Options Purchased -7,500 155.0000 American 18 Jan 2019
ADR Call Options Purchased 7,500 160.0000 American 20 Jul 2018
ADR Call Options Purchased 4,200 180.0000 American 20 Jul 2018
ADR Put Options Written 2,800 120.0000 American 18 Jan 2019
ADR Call Options Purchased 600 165.0000 American 22 Jun 2018
ADR Call Options Purchased 100 110.0000 American 17 Jan 2020
ADR Call Options Purchased 100 140.0000 American 18 Jan 2019
ADR Put Options Written 100 140.0000 American 19 Oct 2018
ADR Call Options Written -200 165.0000 American 29 Jun 2018
ADR Put Options Purchased -1,100 140.0000 American 18 Jan 2019
ADR Put Options Purchased -2,000 175.0000 American 19 Oct 2018
ADR Put Options Purchased -2,100 160.0000 American 18 Jan 2019
ADR Put Options Purchased -3,700 145.0000 American 17 Jan 2020
ADR Call Options Purchased 4,100 135.0000 American 20 Jul 2018
ADR Call Options Purchased 2,000 150.0000 American 17 Jan 2020
ADR Call Options Purchased 1,000 135.0000 American 18 Jan 2019
ADR Put Options Written 700 85.0000 American 20 Jul 2018
ADR Call Options Purchased 500 150.0000 American 18 Jan 2019
ADR Call Options Purchased 400 185.0000 American 20 Jul 2018
ADR Put Options Written 400 145.0000 American 20 Jul 2018
ADR Put Options Written 200 70.0000 American 19 Oct 2018
ADR Put Options Written 100 110.0000 American 18 Jan 2019
ADR Put Options Written 100 75.0000 American 19 Oct 2018
ADR Put Options Purchased -500 145.0000 American 18 Jan 2019
ADR Put Options Purchased -1,000 170.0000 American 17 Jan 2020
ADR Call Options Written -1,100 210.0000 American 19 Oct 2018
ADR Put Options Purchased -1,200 135.0000 American 17 Jan 2020
ADR Put Options Purchased -1,800 115.0000 American 18 Jan 2019
ADR Put Options Purchased -2,400 75.0000 American 20 Jul 2018
5p ordinary Put Options Written 125,000 3600.0000 American 21 Dec 2018

3. AGREEMENTS TO PURCHASE OR SELL ETC.

Full details should be given so that the nature of the interest or position can be fully understood:

It is not necessary to provide details on a Supplemental Form (Open Positions) with regard to cash-settled derivatives.

The currency of all prices and other monetary amounts should be stated.

The Panel's Market Surveillance Unit is available for consultation in relation to the Code's disclosure requirements on +44 (0)20 7638 0129.

The Code can be viewed on the Panel's website atwww.thetakeoverpanel.org.uk.

View source version on businesswire.com:https://www.businesswire.com/news/home/20180621005883/en/

BARCLAYS PLC

Source: BARCLAYS PLC

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Barclays plc published this content on 21 June 2018 and is solely responsible for the information contained herein. Distributed by Public, unedited and unaltered, on 21 June 2018 16:02:08 UTC