Biophytis : presents the mechanism of action of Macuneos for the treatment of AMD, at the Euretina Congress. Read the Press Release

Stanislas Veillet, CEO of BIOPHYTIS, says: "The results presented at Euretina clarify the mechanism of action of Macuneos (BIO201) in the photoprotection of the retina and confirm the role of the PPAR receptors in the pathophysiology of AMD. These results encourage us to conduct the MACA clinical program without delay, and to start the MACA-PK study shortly. The MACA-PK protocol has been optimized to evaluate the effects of Macuneos on the visual function of patients with AMD, for which we expect results in 2018."

The poster presented is entitled as follows:

EVIDENCE FOR THE INVOLVEMENT OF PPARs IN THE PHOTOPROTECTIVE ACTIVITY OF BIO201 (NORBIXIN) ON RETINAL PIGMENT EPITHELIUM.

Fontaine V.1, Monteiro E.1, Fournie M.1, On S.2, Serova M.2, Dilda P.2 and Lafont R.2

1 Sorbonne Universités, UPMC Univ. Paris 06, INSERM, CNRS, Institut de la Vision, Paris, France

2 Biophytis, Paris, France

As conclusion:

• A2E, the phototoxic compound produced through the degradation of the visual pigment, limits the proteic

  expression of PPARα, which is active in the photoprotection mechanism of the retinal pigmentary epithelium,

• Macuneos (BIO201) by activating PPAR receptors and restoring the proteic expression level of PPARα,

protects the cells of the retinal pigmentary epithelium from the phototoxicity of A2E.

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About MACA-PK:

The MACA-PK study is a phase I/IIa clinical study, whose protocol has been optimized to study the safety, pharmacokinetics and pharmacodynamics of Macuneos in healthy volunteers in a Belgian clinical center in 2017, and in patients suffering from dry AMD recruited in 5 ophthalmological centers in France and in Belgium, including the CIC of l'Hôpital des Quinze-Vingt in Paris, in 2018. Biophytis has called on the CRO SGS Life Science Services to conduct this international multicentric clinical study.

Macuneos (BIO201) is the first representative of a new class of drug candidates, agonists of nuclear receptor PPAR. Macuneos protects retinal pigment epithelium: Biophytis has shown in animal models a protection of retinal cells against phototoxic effects of A2E in the presence of blue light (oxidative stress), a reduction in accumulation of A2E, and eventually a slowdown of the degenerative process of the retina. Macuneos is a drug candidate against the dry form of AMD: AMD affects the central part of the retina, called the macula, causing severe visual impairment and irreversible loss of central vision beyond 60 years old. Macuneos is in tablet form (once per day), containing 100 mg or 350 mg of active Pharmaceutical Ingredient (API).

Biophytis SA (www.biophytis.com), founded in 2006, develops drug candidates targeting diseases of aging. Using its technology and know-how, Biophytis has begun clinical development of innovative therapeutics to restore the muscular and visual functions in diseases with significant unmet medical needs. Specifically, the company is advancing two lead products into mid-stage clinical testing this year: Sarconeos (BIO101) to treat sarcopenic obesity and Macuneos (BIO201) to treat dry age-related macular degeneration (AMD).

The business model of BIOPHYTIS is to ensure the conduct of the project until clinical activity in the patient is proven, then to license the technologies in order to continue the development in partnership with a pharmaceutical laboratory.

The company was founded in partnership with researchers at the UPMC (Pierre and Marie Curie University) and also collaborates with scientists at the Institute of Myology, and the Vision Institute.

BIOPHYTIS is listed on the Euronext Growth market of Euronext Paris (ALBPS; ISIN: FR0012816825). For more information: http://www.biophytis.com

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This press release contains certain forward-looking statements. Although the Company believes its expectations are based on reasonable assumptions, these forward-looking statements are subject to numerous risks and uncertainties, which could cause actual results to differ materially from those anticipated. For a discussion of risks and uncertainties which could cause the Company's actual results, financial condition, performance or achievements to differ from those contained in the forward looking statements, please refer to the Risk Factors ("Facteurs de Risque") section of the Listing Prospectus upon the admission of Company's shares for trading on the regulated market Euronext Growth of Euronext Paris filed with the AMF, which is available on the AMF website (www.amf- france.org) or on BIOPHYTIS' website (www.biophytis.com).

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