Findings from Bristol-Myers Squibb Update Understanding of Antihyperlipidemic Agents (Crystal Packing Arrangement, Chain Conformation, and Physicochemical Properties of Gemfibrozil Amine Salts)
By a News Reporter-Staff News Editor at Drug Week -- Research findings on Drugs and Therapies - Antihyperlipidemic Agents are discussed in a new report. According to news reporting from Merseyside, United Kingdom, by NewsRx journalists, research stated, "Salt formation is used to optimize pharmaceutical properties for carboxylic acid drugs, but selection can often be empirical."
Financial support for this research came from Bristol-Myers Squibb (see also Drugs and Therapies - Antihyperlipidemic Agents).
The news correspondents obtained a quote from the research from Bristol-Myers Squibb, "An extended series of salts of the anti-hyperlipidaemia carboxylic acid drug gemfibrozil was prepared using a related series of amine counterions to gain a molecular insight into the impact of crystal packing arrangements on their physicochemical properties. With only a few exceptions, the salts had similar crystal packing motifs."
According to the news reporters, the research concluded: "Although there was no discernible relationship between melting point of the salt form and the aqueous solubility of the salt across the whole data set, there were trends within structurally related series of salts' relating increasing melting enthalpy with increasing molecular weight of the counterion."
For more information on this research see: Crystal Packing Arrangement, Chain Conformation, and Physicochemical Properties of Gemfibrozil Amine Salts. Crystal Growth & Design, 2017;17(7):3743-3750. Crystal Growth & Design can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Crystal Growth & Design - www.pubs.acs.org/journal/cgdefu)
Our news journalists report that additional information may be obtained by contacting P. Timmins, Bristol Myers Squibb, Drug Prod Sci & Technol, Moreton CH46 1QW, Merseyside, United Kingdom. Additional authors for this research include S.E. David, C.H. Schwalbe, K. Asare-Addo, B.K. Conway and M. Ramirez.
Keywords for this news article include: Merseyside, United Kingdom, Europe, Antihyperlipidemic Agents, Fibric Acid Derivatives, Drugs and Therapies, Gemfibrozil Therapy, Organic Chemicals, Carboxylic Acids, Pentanoic Acids, Pharmaceuticals, Clofibric Acid, Bristol-Myers Squibb.
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