Log in
Forgot password ?
Become a member for free
Sign up
Sign up
Dynamic quotes 

4-Traders Homepage  >  Equities  >  Nasdaq  >  Celgene Corporation    CELG

News SummaryMost relevantAll newsSector newsTweets

Celgene : Nimbus Therapeutics Reaches Summit For Deal With Celgene

share with twitter share with LinkedIn share with facebook
share via e-mail
10/04/2017 | 08:11am EDT

Today Nimbus and Celgene announced a significant partnership focused on autoimmune and inflammatory diseases.

The alliance includes two pre-clinical autoimmune-focused programs in various stages of drug discovery. The most advanced program is a highly selective inhibitor of Tyk2, an immunokinase of the JAK family, which plays a central role in the inflammatory response (triggering IL-23, IL-12, and Type-I interferon). Human genetics, including both loss- and gain-of-function changes, validate Tyk2 as perhaps the most critical JAK family member to attenuate in many major autoimmune diseases. Given Tyk2s proximal role in regulating both Th17 and Th1 responses, the target is one of the most sought after by immunology R&D groups. BMS has a competing Tyk2 program in early clinical development. The figure below illustrates why a safe, well tolerated oral Tyk2 inhibitor has enormous potential: it would not only replicate the efficacy of multiple blockbuster mAbs, but also explore a large number of other autoimmune diseases beyond psoriasis and RA.

Another program in this alliance with Celgene is a small molecule, non-nucleotide antagonist of STING, a pattern recognition receptor in innate immune responses. In I/O today, STING agonists are believed to be of value in turning up the immune response to tumors; this antagonist program is aimed at doing the opposite to turn down inflammation in the context of autoimmunity, and STING activation has been implicated in the pathogenesis of diseases like lupus.

This deal, dubbed Project Everest as a reference to Celgenes corporate headquarters in Summit, NJ, was the product of over a years worth of active dialogues between the two leadership teams. Were excited to work with Celgene on these programs as they are great fits with their growing I&I franchise.

Beyond affirming the compelling science underpinning these programs, this deal provides further validation for the Nimbus Therapeutics tripartite value creation approach: cutting-edge computational drug discovery; globally-distributed, virtually-integrated operations; and, a novel asset-centric corporate structure LLC.

These three elements were central to our investment thesis when we seeded the startup in 2009, and again when we came out of stealth mode in spring 2011, culminating in our Series A round. Over the past six years, theres been several posts on Nimbus model and success (including early deal-making with the LLC structure, running virtual companies and the Uber-like disruption in this operating configuration, etc.). But to sum up these three pillars briefly:

Compelling scientific platform. Nimbus has a privileged relationship with our computational partner and co-founder, Schrdinger. Early on we were inspired by new approaches to understanding solvent energetics (unstable waters), but this relationship has grown into next generation techniques around FEP of ligands and proteins and better force fields. Further, we bring a host of other key technologies to bear, like crystallography, ADME prediction, and proprietary in silico designed molecular scaffolds, to name a few. On its own, technology isnt a viable standalone solution, as described in my cautionary post on Four Decades Of Hacking Biotech And Yet Biology Still Consumes Everything. Integration of this powerful technology suite within a team of bona fide drug hunters, who possess both a nose and judgment for drug discovery, is the critical ingredient in making this work.

(c) Copyright: Arab News 2017 All rights reserved. Provided by SyndiGate Media Inc. (Syndigate.info)., source Middle East & North African Newspapers

share with twitter share with LinkedIn share with facebook
share via e-mail
08:12a CELGENE CORPORATION : Today's Research Reports on Stocks to Watch: Celgene Corpo..
08:10a CELGENE : Results from Phase 2 Studies of Oral Ozanimod in Crohn's Disease and U..
08:02a CELGENE : Results from Phase 2 Studies of Oral Ozanimod in Crohn’s Disease..
10/13 CELGENE : Sutro Marks Two Drug Development Milestones
10/12 CELGENE : Nimbus Therapeutics and Celgene Enter Long-Term Strategic Immunology A..
10/12 EVOTEC : achieves first milestone in neurodegeneration alliance with Celgene
10/07 BRISTOL MYERS SQUIBB : Industry Leaders Gather at Medidata NEXT Global 2017 to D..
10/05 Celgene pens pact to join Bristol-Myers, Pfizer in R&D race
10/04 CELGENE : Nimbus Therapeutics Reaches Summit For Deal With Celgene
10/04 CELGENE CORPORATION : to Announce Third Quarter 2017 Results
More news
News from SeekingAlpha
12:29p President Trump at it again with comments on "out of control" drug prices
10/14 Stocks to watch next week
10/12 Acceleron's Unique Pipeline Looks Undervalued
10/10 The 2 Cardinal Rules For Successful Biotech Investing
Financials ($)
Sales 2017 13 249 M
EBIT 2017 7 532 M
Net income 2017 4 348 M
Debt 2017 3 768 M
Yield 2017 -
P/E ratio 2017 24,19
P/E ratio 2018 18,67
EV / Sales 2017 8,34x
EV / Sales 2018 6,82x
Capitalization 107 B
Duration : Period :
Celgene Corporation Technical Analysis Chart | CELG | US1510201049 | 4-Traders
Technical analysis trends CELGENE CORPORATION
Short TermMid-TermLong Term
Income Statement Evolution
Mean consensus OUTPERFORM
Number of Analysts 27
Average target price 154 $
Spread / Average Target 13%
EPS Revisions
Mark J. Alles Chief Executive Officer & Director
Scott Andrew Smith President & Chief Operating Officer
Robert J. Hugin Executive Chairman
Peter N. Kellogg Chief Financial Officer & Executive Vice President
Joseph S. Camardo Senior Vice President-Global Medical Affairs
Sector and Competitors
1st jan.Capitalization (M$)
JOHNSON & JOHNSON18.42%366 178
NOVARTIS13.23%225 160
ROCHE HOLDING LTD.5.20%216 764
PFIZER11.88%216 409