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LONDON, UK / ACCESSWIRE / February 08, 2018 / Active-Investors.com has just released a free research report on Compugen Ltd (NASDAQ: CGEN). If you want access to this report all you need to do is sign up now by clicking the following link www.active-investors.com/registration-sg/?symbol=CGEN as the Company's latest news hit the wire. On February 06, 2018, the Company, a therapeutic discovery firm, announced the online publication of the data pertaining to the discovery and validation of the ILDR2 protein as a novel immune checkpoint and its use as an Fc fusion protein for the treatment of auto-immune diseases in two peer-reviewed papers in The Journal of Immunology. Antibody-based therapeutics targeting ILDR2 (CGEN-15001T) for immuno-oncology were licensed to Bayer AG, while Compugen retains the full rights to the fusion protein CGEN-15001. Register today and get access to over 1000 Free Research Reports by joining our site below:

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Active-Investors.com is focused on giving you timely information and the inside line on companies that matter to you. This morning, Compugen most recent news is on our radar and our team decided to put out a fantastic report on the company that is now available for free below:

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Compugen, First to Publish Data on ILDR2 as a New Immune Checkpoint with a Therapeutic Role in Auto-Immune Diseases

Anat Cohen-Dayag, PhD, President and Chief Executive Officer (CEO) of Compugen, mentioned that Compugen is the first to publish data on ILDR2 as a new immune checkpoint with a potential therapeutic role in auto-immune diseases and cancer immuno-therapy, each presenting first-in-class therapeutic opportunities. This is the third novel immune checkpoint disclosed by the Company, following PVRIG and TIGIT. Cohen-Dayag added that Compugen has identified a new pathway with robust and diversified data supporting ILDR2 mechanism-of-action and broad therapeutic potential, both for the treatment of auto-immune diseases and for cancer immuno-therapy.

Publications Supporting Immune-Related Functions of ILDR2 and Its Use in Auto-Immune Diseases

  • ILDR2, a Novel B7-like Protein that Negatively Regulates T Cell Responses - The publication describes the computational discovery approach leading to the discovery of ILDR2 as a novel immune checkpoint. The experimental validation of the role of this protein as a negative regulator of T cell activity was established. The publication reports the beneficial effects of CGEN-15001 in an animal model of rheumatoid arthritis (RA), as well as in a translational assay utilizing blood cells from RA patients that mimics the deleterious interactions of immune cells in the RA synovium. These findings assign a new role to the ILDR2 protein, whose immune-related function was not previously known.
  • ILDR2-Fc, a Novel Regulator of Immune Homeostasis and Inducer of Antigen-Specific Immune Tolerance - In a pre-clinical research, an additional paper was published demonstrating the potential of ILDR2-Fc fusion protein to address auto-immune and inflammatory conditions, as well as the mechanism of action underlying this activity. The data showed the potent and long-lasting immuno-modulatory activity of ILDR2-Fc fusion protein in animal models of multiple sclerosis (R-EAE) and type 1 diabetes, and its ability to promote engraftment in an animal model of bone marrow transplantation. These findings point to a compelling mode of action for this Fc fusion protein in auto-immune diseases.

CGEN-15001 Demonstrated Restoration of Immune Tolerance in Auto-Immunity

In January 2017, the Company disclosed new animal model results demonstrating the restoration of immune tolerance by CGEN-15001. The immune tolerance established by CGEN-15001 was shown to be antigen-specific, indicating that treatment with CGEN-15001 has the potential to not only generate a durable response, but also to avoid the global immune suppression generated by other therapeutic agents for auto-immune diseases.

Compugen Collaboration with Bayer in Immuno-Oncology

In July 2017, Compugen announced updates to its collaborative activities in immuno-oncology with Bayer. The agreement with Bayer involves the research, development, and commercialization of antibody-based therapeutics against novel immune checkpoint regulator, CGEN-15001T. As announced in August 2013, the CGEN-15001T program continues to be advanced by Bayer towards human clinical trials, for which pre-clinical stage milestones have been achieved.

About Auto-Immune Diseases

An auto-immune disease is a condition in which one's immune system mistakenly attacks one's body. There are at least 80 types of auto-immune diseases. Nearly any body part can be involved. The common symptoms include low grade fever and tiredness. Often symptoms come and go. Some auto-immune diseases, such as lupus, run in families, and certain cases may be triggered by infections or other environmental factors.

About CGEN-15001

CGEN-15001, Compugen's lead program, is an Fc fusion protein consisting of the extracellular domain of ILDR2 and an Fc domain, for the potential use in auto-immune diseases. It is a first-in-class therapeutic candidate of a novel inhibitory checkpoint pathway, with the potential to restore immune tolerance and re-establish immune homeostasis, thus potentially offering patients a durable therapeutic response and a safer treatment profile.

About Compugen Ltd

Founded in 1993 and headquartered in Holon, Israel, Compugen is a drug discovery Company with a unique, broadly applicable, predictive discovery infrastructure, which is advancing a therapeutic pipeline consisting mainly of early-stage immuno-oncology programs, aimed at harnessing the immune system to eradicate cancer in the United States, Europe, and Israel.

Stock Performance Snapshot

February 07, 2018 - At Wednesday's closing bell, Compugen's stock slightly rose 0.94%, ending the trading session at $2.67.

Volume traded for the day: 183.28 thousand shares.

Stock performance in the last month ? up 4.90%; and year-to-date - up 7.00%

After yesterday's close, Compugen's market cap was at $139.80 million.

The stock is part of the Healthcare sector, categorized under the Biotechnology industry.

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