DGAP-News: Heidelberg Pharma AG / Key word(s): Study results PRESS RELEASE Heidelberg Pharma AG announces results from research collaboration with Heidelberg University and the DKFZ to be presented at ASH Annual Meeting - ATAC efficacy evaluated in multiple myeloma cells - Promising top-line results with HDP-101 available - Research results to be presented at American Society of Hematology (ASH) Annual Meeting in early December Ladenburg, Germany, 13 November 2017 - Heidelberg Pharma AG (ISIN DE000A11QVV0 / WKN A11QVV / WL6) today announced that it will present top-line results from a research collaboration with Heidelberg University and the German Cancer Research Center (DKFZ) led by Dr. Marc-Steffen Raab at the 59th ASH (American Society of Hematology) Annual Meeting, the leading conference for hematologic diseases, taking place from 9 to 12 December 2017 in Atlanta, GA, USA. The collaboration evaluated the efficacy of the development candidate HDP-101 on multiple myeloma cells isolated from patients. HDP-101 consists of a BCMA antibody, a specific linker and the toxin Amanitin. BCMA (B-cell maturation antigen) is a surface protein that is selectively expressed in multiple myeloma cells and to which the selected antibody specifically binds. In the jointly conducted preclinical study, non-dividing cancer cells taken from multiple myeloma patients were examined with HDP-101. A strong cytotoxic effect was observed including at very low doses, even in cancer cells with a low concentration of BCMA antigens. No toxicity was observed on non-BCMA expressing control cells. This is the first time that the efficacy of Amanitin on cancer cells taken from human patients was demonstrated. Antibody drug conjugates (ADCs) with Amanitin represent a novel therapeutic approach for treating multiple myeloma. The toxin's biological mode of action could break through drug resistance and improve the prognosis of patients. Heidelberg Pharma expects to initiate a clinical trial with HDP-101 by the end of 2018. Professor Andreas Pahl, Chief Scientific Officer of Heidelberg Pharma AG, commented: "This preclinical study in multiple myeloma carried out jointly with Heidelberg University and the DKFZ demonstrates the effect of our candidate HDP-101 on tumor cells isolated directly from patients, providing us with further important support of the efficacy of our first proprietary ATAC candidate HDP-101, which is of major importance to us. We are delighted that the results will be presented at such an important event as the ASH Annual Meeting." Presentation details: Poster: 3070 Preclinical Evaluation of HDP-101, a Novel Anti-Bcma Antibody-Drug Conjugate, in Multiple Myeloma The abstract is available online and will also be published in a special issue of "Blood" on 8 December 2017. About Heidelberg Pharma AG
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13.11.2017 Dissemination of a Corporate News, transmitted by DGAP - a service of EQS Group AG. |
Language: | English |
Company: | Heidelberg Pharma AG |
Schriesheimer Str. 101 | |
68526 Ladenburg | |
Germany | |
Phone: | +49 (0)89 41 31 38 - 0 |
Fax: | +49 (0)89 41 31 38 - 99 |
E-mail: | info@hdpharma.com |
Internet: | www.heidelberg-pharma.com |
ISIN: | DE000A11QVV0 |
WKN: | A11QVV |
Listed: | Regulated Market in Frankfurt (Prime Standard); Regulated Unofficial Market in Berlin, Dusseldorf, Munich, Stuttgart, Tradegate Exchange |
End of News | DGAP News Service |
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