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Johnson & Johnson : Reports on Pharmaceutical Research Findings from Johnson & Johnson Provide New Insights (Importance of in vitro dissolution conditions for the in...

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10/05/2017 | 05:58pm CET

Reports on Pharmaceutical Research Findings from Johnson & Johnson Provide New Insights (Importance of in vitro dissolution conditions for the in vivo predictability of an amorphous solid dispersion containing a pH-sensitive carrier)

By a News Reporter-Staff News Editor at Drug Week -- Investigators publish new report on Drugs and Therapies - Pharmaceutical Research. According to news reporting originating from Beerse, Belgium, by NewsRx correspondents, research stated, "The present study investigated the influence of in vitro dissolution conditions on the in vivo predictability of an amorphous solid dispersion of celecoxib (CCX) in the pH-sensitive polymer Eudragit ® S 100. Different doses of a 25:75 w/w% CCX: Eudragit ® S 100 amorphous solid dispersion (CCX:EUD) were investigated."

Our news editors obtained a quote from the research from Johnson & Johnson, "During in vitro dissolution a significant effect of the pH of the dissolution media on the release of CCX was observed. In fasted state simulated intestinal fluid (FaSSIF) pH 6.5, the release of CCX from the amorphous solid dispersion was comparable to that of crystalline CCX and lower than that of amorphous CCX whereas in FaSSIF pH 7.4, the release was significantly increased compared to both crystalline and amorphous CCX. With a 3-fold increase in the exposure of CCX: EUD compared to crystaline CCX. The in vivo data also suggested that Eudragit ® S 100 was suitable as a carrier in amorphous solid dispersions of CCX. In vitro-in vivo correlation demonstrated that the in vitro data obtained in FaSSIF pH 7.4 was more predictive for the in vivo performance than that obtained in FaSSIF pH 6.5."

According to the news editors, the research concluded: "Consequently, the findings of this study underline that when predicting the in vivo performance of amorphous solid dispersions with pH-sensitive polymers, it is imperative that the in vitro dissolution conditions are carefully considered."

For more information on this research see: Importance of in vitro dissolution conditions for the in vivo predictability of an amorphous solid dispersion containing a pH-sensitive carrier. International Journal of Pharmaceutics, 2017;531(1):324-331. International Journal of Pharmaceutics can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; International Journal of Pharmaceutics - www.journals.elsevier.com/international-journal-of-pharmaceutics/)

The news editors report that additional information may be obtained by contacting R. Holm, Johnson & Johnson, Drug Prod Dev, Janssen Res & Dev, BE-2340 Beerse, Belgium. Additional authors for this research include M.M. Knopp, F. Khan, N. Chourak, T. Rades and J. Wendelboe (see also Drugs and Therapies - Pharmaceutical Research).

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1016/j.ijpharm.2017.08.078. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

Keywords for this news article include: Beerse, Belgium, Europe, Pharmaceutical Research, Drugs and Therapies, Johnson & Johnson.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2017, NewsRx LLC

(c) 2017 NewsRx LLC, source Health Newsletters

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