KANEKA CORPORATION 
By
August 6, 2013
Effect ofUbiquinol (reduced form ofCoenzyme Q10) on Chronic Fatigue Syndrome (CFS) in double-blind placebo controlled study
-Collaborative research with Osaka City University-
Kaneka Corporation (headquarters: Osaka, Japan; President: Mr_ Kimikazu Sugawara) confirmed the effect of the Reduced form of Coenzyme Q10 (hereafter, Ubiquinol) in improving the Chronic Fatigue Syndrome (CFS) showing long-lasting fatigue, tiredness, etc. with unknown cause. This research was conducted in collaboration with Special Appointment Prof. Yasuyoshi Watanabe, Graduate School of Medicine, Osaka City University, Osaka, Japan (President and Chairperson of the board of directors: Dr. Yoshiki Nishizawa), and Director of Center for Life Science Technologies, RIKEN, Kobe, Japan)
These results were presented at the 9th Annual Meeting of the Japanese Society of Fatigue
Science held atAkita, Japan on June 7-8, 2013.
This is a double- blind placebo-controlled study. Thirty one patients were divided into two groups (Active; n=17, placebo; n=14) and were supplemented with Ubiquinol (150mg/day) or placebo capsules for 3 months. Fatigue, sleep quality and depression, oxidative stress and anti-oxidative activity and arithmetic tasks were evaluated before and after 3 months of the supplementation.
As the results, frequency of nocturnal awakening was significantly decreased and performance of arithmetic task was improved significantly after supplementation. Plasma Ubiquinol concentration was also increased significantly. Since these results were accorded well with those obtained in our open-label study previously conducted to evaluate the effect ofUbiquinol in CFS patients at daily dose of 150mg for 8 weeks, the clinical effect of Ubiquinol on CFS was confirmed.
Copyright ©Kaneka Corporation, All rights reserved.
KANEKA CORPORATION
(Times) (Mean+SE)
15 D Placebo (n=14)
l Ubiquinol (n=17)
10
5
o,_ . ,
Over one minute Over five minute
Frequency of nocturnal awakening
* p<;,u.uo
Ubiquinol showed improvement of sleep quality compared with placebo
Copyright ©Kaneka Corporation, All rights reserved.
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