FORM 8.3

           PUBLIC OPENING POSITION DISCLOSURE/DEALING DISCLOSURE BY

    A PERSON WITH INTERESTS IN RELEVANT SECURITIES REPRESENTING 1% OR MORE

                  Rule 8.3 of the Takeover Code (the "Code")

1. KEY INFORMATION

(a) Identity of the person whose positions/    Magnetar Financial (UK) LLP
dealings are being disclosed:

(b) Owner or controller of interests and short N/A
positions disclosed, if different from 1(a):

The naming of nominee or vehicle companies is
insufficient

(c) Name of offeror/offeree in relation to     SHIRE PLC
whose relevant securities this form relates:

Use a separate form for each offeror/offeree

(d) If an exempt fund manager connected with   N/A
an offeror/offeree, state this and specify
identity of offeror/offeree:

(e) Date position held/dealing undertaken:     August 26, 2014

(f) Has the discloser previously disclosed, or Yes - AbbVie Inc
are they today disclosing, under the Code in
respect of any other party to this offer?

2. POSITIONS OF THE PERSON MAKING THE DISCLOSURE

(a) Interests and short positions in the relevant securities of the offeror or
offeree to which the disclosure relates following the dealing (if any)

Class of relevant security:                   5p Ordinary and

                                                    ADS

                                      Interests            Short positions


        Number                %          Number         %

(1) Relevant securities   7,134,362
owned and/or
controlled:

(2) Derivatives (other
than options):

(3) Options and
agreements to purchase/
sell:

TOTAL:                    7,134,362   1.21%

All interests and all short positions should be disclosed.

Details of any open derivative or option positions, or agreements to purchase
or sell relevant securities, should be given on a Supplemental Form 8 (Open
Positions).

(b) Rights to subscribe for new securities (including directors' and other
executive options)

Class of relevant security in
relation to which subscription right
exists:

Details, including nature of the
rights concerned and relevant
percentages:

If there are positions or rights to subscribe to disclose in more than one
class of relevant securities of the offeror or offeree named in 1(c), copy
table 2(a) or (b) (as appropriate) for each additional class of relevant
security.

3. DEALINGS (IF ANY) BY THE PERSON MAKING THE DISCLOSURE

(a) Purchases and sales

 Class of relevant    Purchase/sale         Number of        Price per unit
     security                              securities

        Ord         Purchase                 207,543            48.9646

        Ord         Purchase                 247,500            48.7386

        ADS         Purchase                 40,000             244.1251

        ADS         Purchase                 30,000             244.0725

(b) Derivatives transactions (other than options)

   Class of      Product      Nature of dealing     Number of     Price per
   relevant    description                          reference       unit
   security                 e.g. opening/closing a  securities
                 e.g. CFD    long/short position,
                            increasing/reducing a
                             long/short position


(c) Options transactions in respect of existing securities

(i) Writing, selling, purchasing or varying

Class of   Product    Writing,   Number of  Exercise    Type     Expiry    Option
relevant description purchasing, securities  price                date     money
security  e.g. call   selling,    to which  per unit    e.g.               paid/
           option      varying     option            American,            received
                        etc.      relates             European            per unit
                                                        etc.

ADS      Put Option  Purchase    31,300     180.00   American   September .2275
                                                                20, 2014

ADS      Put Option  Purchase    50,000     220.00   American   September 2.1250
                                                                20, 2014

ADS      Call Option Writing     100,000    260.00   American   October   3.5000
                                                                18, 2014

ADS      Put Option  Purchase    100,000    200.00   American   October   2.0000
                                                                18, 2014

(ii) Exercising

 Class of relevant       Product            Number of      Exercise price per
     security          description         securities             unit

                     e.g. call option


(d) Other dealings (including subscribing for new securities)

Class of relevant    Nature of dealing          Details       Price per unit
    security                                                 (if applicable)
                     e.g. subscription,
                         conversion


The currency of all prices and other monetary amounts should be stated.

Where there have been dealings in more than one class of relevant securities of
the offeror or offeree named in 1(c), copy table 3(a), (b), (c) or (d) (as
appropriate) for each additional class of relevant security dealt in.

4. OTHER INFORMATION

(a) Indemnity and other dealing arrangements

Details of any indemnity or option arrangement, or any agreement or
understanding, formal or informal, relating to relevant securities which may
be an inducement to deal or refrain from dealing entered into by the person
making the disclosure and any party to the offer or any person acting in
concert with a party to the offer:

If there are no such agreements, arrangements or understandings, state "none"


(b) Agreements, arrangements or understandings relating to options or
derivatives

Details of any agreement, arrangement or understanding, formal or informal,
between the person making the disclosure and any other person relating to:

(i) the voting rights of any relevant securities under any option; or

(ii) the voting rights or future acquisition or disposal of any relevant
securities to which any derivative is referenced:

If there are no such agreements, arrangements or understandings, state "none"


(c) Attachments

Is a Supplemental Form 8 (Open Positions) attached?                 Yes

Date of disclosure:                    August 27, 2014

Contact name:                          Julianna Ethell

Telephone number:                      847-905-4688

Public disclosures under Rule 8 of the Code must be made to a Regulatory
Information Service and must also be emailed to the Takeover Panel at
monitoring@disclosure.org.uk. The Panel's Market Surveillance Unit is available
for consultation in relation to the Code's dealing disclosure requirements on
+44 (0)20 7638 0129.

The Code can be viewed on the Panel's website at www.thetakeoverpanel.org.uk.

                     SUPPLEMENTAL FORM 8 (OPEN POSITIONS)

DETAILS OF OPEN OPTION AND DERIVATIVE POSITIONS, AGREEMENTS TO PURCHASE OR SELL
                                     ETC.
             Note 5(i) on Rule 8 of the Takeover Code (the "Code")

1. KEY INFORMATION

Identity of person whose open positions are    Magnetar Financial (UK) LLP
being disclosed:

Name of offeror/offeree in relation to whose   Shire Plc
relevant securities the disclosure relates:

2. OPTIONS AND DERIVATIVES

Class of    Product   Written or   Number of  Exercise     Type      Expiry
relevant  description  purchased  securities  price per    e.g.       date
security   e.g. call               to which     unit    American,
            option                 option or             European
                                  derivative               etc.
                                    relates

ADS       Put Option  Purchased   39,200      180.00    American   September
                                                                   20, 2014

ADS       Put Option  Written     305,200     190.00    American   September
                                                                   20, 2014

ADS       Put Option  Purchased   204,200     215.00    American   September
                                                                   20, 2014

ADS       Put Option  Purchased   255,200     220.00    American   September
                                                                   20, 2014

ADS       Call Option Written     559,500     260.00    American   October
                                                                   18, 2014

ADS       Put Option  Purchased   559,500     200.00    American   October
                                                                   18, 2014

3. AGREEMENTS TO PURCHASE OR SELL ETC.

Full details should be given so that the nature of the interest or position
can be fully understood:


It is not necessary to provide details on a Supplemental Form (Open Positions)
with regard to contracts for differences ("CFDs") or spread bets.

The currency of all prices and other monetary amounts should be stated.

The Panel's Market Surveillance Unit is available for consultation in relation
to the Code's dealing disclosure requirements on +44 (0)20 7638 0129.

The Code can be viewed on the Panel's website at www.thetakeoverpanel.org.uk

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