Transaction amended in 3(a)



                                                                       FORM 8.3

           PUBLIC OPENING POSITION DISCLOSURE/DEALING DISCLOSURE BY

    A PERSON WITH INTERESTS IN RELEVANT SECURITIES REPRESENTING 1% OR MORE

                  Rule 8.3 of the Takeover Code (the "Code")

1. KEY INFORMATION

(a) Identity of the person whose positions/    Pentwater Capital Management
dealings are being disclosed:                  LP

(b) Owner or controller of interests and short
positions disclosed, if different from 1(a):

The naming of nominee or vehicle companies is
insufficient

(c) Name of offeror/offeree in relation to     Shire Plc
whose relevant securities this form relates:

Use a separate form for each offeror/offeree

(d) If an exempt fund manager connected with   N/A
an offeror/offeree, state this and specify
identity of offeror/offeree:

(e) Date position held/dealing undertaken:     October 15, 2014

(f) Has the discloser previously disclosed, or Yes-AbbVie Inc
are they today disclosing, under the Code in
respect of any other party to this offer?

2. POSITIONS OF THE PERSON MAKING THE DISCLOSURE

(a) Interests and short positions in the relevant securities of the offeror or
offeree to which the disclosure relates following the dealing (if any)

Class of relevant security:

                                     Interests            Short positions

                                  Number         %        Number         %

(1) Relevant securities owned    2,863,886     0.49%
and/or controlled:

(2) Derivatives (other than      1,298,603     0.22%
options):

(3) Options and agreements to                             300,000      0.05%
purchase/sell:

TOTAL:                           4,162,489     0.71%      300,000      0.05%

All interests and all short positions should be disclosed.

Details of any open derivative or option positions, or agreements to purchase
or sell relevant securities, should be given on a Supplemental Form 8 (Open
Positions).

(b) Rights to subscribe for new securities (including directors' and other
executive options)

Class of relevant security in
relation to which subscription right
exists:

Details, including nature of the
rights concerned and relevant
percentages:

If there are positions or rights to subscribe to disclose in more than one
class of relevant securities of the offeror or offeree named in 1(c), copy
table 2(a) or (b) (as appropriate) for each additional class of relevant
security.

3. DEALINGS (IF ANY) BY THE PERSON MAKING THE DISCLOSURE

(a) Purchases and sales

 Class of relevant    Purchase/sale         Number of        Price per unit
     security                              securities

     ordinary              sale        100,000             37.00 GBP

     ordinary              sale        7,500               37.07 GBP

     ordinary              sale        450,000             37.81 GBP

     ordinary              sale        100,000             37.90 GBP

     ordinary              sale        100,000             38.00 GBP

     ordinary              sale        11,250              38.17 GBP

     ordinary              sale        132,925             38.35 GBP

     ordinary              sale        200,000             38.73 GBP

     ordinary              sale        278,880             38.85 GBP

     ordinary              sale        150,000             39.84 GBP

     ordinary              sale        200,000             40.01 GBP

     ordinary              sale        18,562              40.12 GBP

ADS                      purchase      150,000             160.86 USD

ADS                        sale        219,900             168.93 USD

ADS                        sale        50,100              172.23 USD

(b) Derivatives transactions (other than options)

   Class of       Product       Nature of dealing     Number of     Price per
   relevant     description                           reference        unit
   security                  e.g. opening/closing a   securities
                  e.g. CFD    long/short position,
                              increasing/reducing a
                               long/short position

   ordinary         CFD      Increasing long            18,562      40.12 GBP
                             position

   ordinary         CFD      Reducing long position     192,500     37.07 GBP

   ordinary         CFD      Reducing long position     15,360      37.81 GBP

   ordinary         CFD      Reducing long position     288,750     38.17 GBP

   ordinary         CFD      Reducing long position    1,438,195    38.35 GBP

   ordinary         CFD      Reducing long position    1,184,640    37.81 GBP

(c) Options transactions in respect of existing securities

(i) Writing, selling, purchasing or varying

Class of   Product    Writing,   Number of  Exercise   Type     Expiry    Option
relevant description purchasing, securities  price               date     money
security  e.g. call   selling,    to which  per unit   e.g.               paid/
           option      varying     option            American,           received
                        etc.      relates            European            per unit
                                                       etc.


(ii) Exercising

 Class of relevant   Product description      Number of      Exercise price per
     security                                 securities            unit
                      e.g. call option


(d) Other dealings (including subscribing for new securities)

Class of relevant    Nature of dealing          Details       Price per unit
    security                                                 (if applicable)
                     e.g. subscription,
                         conversion


The currency of all prices and other monetary amounts should be stated.

Where there have been dealings in more than one class of relevant securities of
the offeror or offeree named in 1(c), copy table 3(a), (b), (c) or (d) (as
appropriate) for each additional class of relevant security dealt in.

4. OTHER INFORMATION

(a) Indemnity and other dealing arrangements

Details of any indemnity or option arrangement, or any agreement or
understanding, formal or informal, relating to relevant securities which may
be an inducement to deal or refrain from dealing entered into by the person
making the disclosure and any party to the offer or any person acting in
concert with a party to the offer:

If there are no such agreements, arrangements or understandings, state "none"


(b) Agreements, arrangements or understandings relating to options or
derivatives

Details of any agreement, arrangement or understanding, formal or informal,
between the person making the disclosure and any other person relating to:

(i) the voting rights of any relevant securities under any option; or

(ii) the voting rights or future acquisition or disposal of any relevant
securities to which any derivative is referenced:

If there are no such agreements, arrangements or understandings, state "none"


(c) Attachments

Is a Supplemental Form 8 (Open Positions) attached?           YES

Date of disclosure:                    October 16, 2014

Contact name:                          Neal Nenadovic

Telephone number:                      312-589-6405

Public disclosures under Rule 8 of the Code must be made to a Regulatory
Information Service and must also be emailed to the Takeover Panel at
monitoring@disclosure.org.uk . The Panel's Market Surveillance Unit is
available for consultation in relation to the Code's dealing disclosure
requirements on +44 (0)20 7638 0129.

The Code can be viewed on the Panel's website at www.thetakeoverpanel.org.uk .

                                           SUPPLEMENTAL FORM 8 (OPEN POSITIONS)

DETAILS OF OPEN OPTION AND DERIVATIVE POSITIONS, AGREEMENTS TO PURCHASE OR SELL
                                     ETC.

             Note 5(i) on Rule 8 of the Takeover Code (the "Code")

1. KEY INFORMATION

Identity of person whose open positions are    Pentwater Capital Management
being disclosed:                               LP

Name of offeror/offeree in relation to whose   Shire Plc
relevant securities the disclosure relates:

2. OPTIONS AND DERIVATIVES

 Class of    Product   Written or  Number of   Exercise      Type      Expiry
 relevant  description  purchased  securities  price per                date
 security   e.g. call               to which     unit        e.g.
             option                option or              American,
                                   derivative              European
                                    relates                  etc.

ADS        Put option  Purchased   300,000    230.00 USD  American   18 Oct 14

3. AGREEMENTS TO PURCHASE OR SELL ETC.

Full details should be given so that the nature of the interest or position
can be fully understood:


It is not necessary to provide details on a Supplemental Form (Open Positions)
with regard to contracts for differences ("CFDs") or spread bets.

The currency of all prices and other monetary amounts should be stated.

The Panel's Market Surveillance Unit is available for consultation in relation
to the Code's dealing disclosure requirements on +44 (0)20 7638 0129.

The Code can be viewed on the Panel's website at www.thetakeoverpanel.org.uk .