By a News Reporter-Staff News Editor at Journal of Engineering -- According to news reporting originating from Alexandria, Virginia, by VerticalNews journalists, a patent by the inventors Blakey, David Mark (Hertfordshire, GB); Day, Richard Francis (Cambridgeshire, GB), filed on July 19, 2010, was published online on July 21, 2015.
The assignee for this patent, patent number 9084862, is NEKTAR THERAPEUTICS (San Carlos, CA).
Reporters obtained the following quote from the background information supplied by the inventors: "Embodiments of the present invention relate to nebulizers. In particular, the present invention relates to use of a nebulizer with a sealed drug reservoir to build up and maintain an internal negative bias pressure.
"A wide variety of procedures have been proposed to deliver a drug to a patient. In some drug delivery procedures the drug is a liquid and is dispensed in the form of fine liquid droplets for inhalation by a patient. A patient may inhale the drug for absorption through lung tissue. Further, the droplets forming the mist may need to be very small to travel through small airways of the patient's lungs, and consistent in size to assure proper absorption. Such a mist may be formed by a nebulizer."
In addition to obtaining background information on this patent, VerticalNews editors also obtained the inventors' summary information for this patent: "Creating a negative bias pressure on the liquid side of an aperture used for aerosolizing liquid drug may allow for more efficient and consistent delivery of aerosolized liquid drugs to a patient. Such a negative bias may be created by reducing the pressure within the drug reservoir of a nebulizer. This may be accomplished by sealing the drug reservoir then discharging an amount of liquid drug from the reservoir. Because neither air, nor anything else, is able to fill the space vacated by the discharged liquid drug, the pressure within the drug reservoir decreases, thereby creating a negative bias pressure within the liquid drug reservoir and on the liquid side of the aperture aerosolizing the liquid drug.
"In some embodiments, a method for creating a negative bias pressure within a sealed reservoir may be present. The method may include providing a liquid reservoir coupled with an aerosol generator, the aerosol generator comprising an aperture plate, the aperture plate having a liquid side and an air side. The method may also include receiving a liquid in the liquid reservoir. The method may include sealing the liquid reservoir to create the sealed reservoir. An ambient pressure may be maintained while the liquid reservoir is being sealed. The ambient pressure may be maintained in the sealed liquid reservoir until a portion of the liquid is dispensed. The method may include vibrating the aperture plate to dispense liquid. Dispensing liquid may decrease the amount of liquid in the sealed reservoir. The method may include decreasing the amount of liquid in the sealed reservoir to create a negative bias pressure between an air side and a liquid side of the aperture plate.
"In some embodiments, a cap is provided, wherein the cap comprises a first portion configured to couple with die liquid reservoir and a second portion configured to screw into the first portion of the cap. The method may further comprise screwing the second portion of the cap into the first portion of the cap, wherein a passageway allows the ambient pressure to be maintained in the liquid reservoir as the second portion of the cap is screwed into the first portion of the cap. In some embodiments, a cap is provided, wherein the cap comprises a flexible seal and a pivot. The method may include pivoting the cap against the liquid reservoir such that the flexible seal seals the liquid reservoir. In some embodiments, a cap is provided that comprises a one-way valve and a seal. The method may thither include pressing the cap onto the liquid reservoir such that the seat couples the cap with the liquid reservoir, wherein the one-way valve the ambient pressure to be maintained as the liquid reservoir is sealed. In some embodiments, the cap is shaped to reduce headspace within the liquid reservoir. In some embodiments, a cap is provided that comprises a plunger and a stopper. The method may further include placing the cap on the liquid reservoir such that the cap covers the liquid reservoir, wherein the ambient pressure is maintained by a passageway between the cap and the stopper. The method may further comprise pulling the plunger of the cap, wherein the plunger seals the liquid reservoir by moving the stopper to obstruct the passageway between the stopper and the cap.
"In some embodiments, sealing the liquid reservoir to create the sealed reservoir uses a reservoir cap. The method may further comprise, releasing, via the reservoir cap, air as the liquid reservoir is sealed to create the sealed reservoir. The method may further comprise unsealing the liquid reservoir using a reservoir cap; placing additional liquid in the liquid reservoir; and resealing the liquid reservoir using the reservoir cap. Also, the method may comprise receiving, by the aerosol generator, a control signal from a driver unit. The control signal from the driver unit may be used to vibrate the aperture plate to dispense liquid. The liquid may be a drug and the liquid reservoir may be a liquid drug reservoir.
"In some embodiments, a system for creating a negative bias pressure within, a liquid reservoir is present. The system may include an aerosol generator comprising an aperture plate having a liquid side and an air side, wherein the aerosol plate is configured to be vibrated to dispense liquid. The liquid reservoir may be configured to: receive liquid; store liquid; discharge liquid to the aerosol generator; and seal, such that a negative bias pressure develops between the liquid side and the air side of the aperture plate as liquid is discharged from the liquid reservoir. The system may include a cap configured to maintain an ambient pressure while the liquid reservoir is being sealed. The ambient pressure may be maintained in the sealed liquid reservoir until a portion of the liquid is dispensed.
"In some embodiments, a system for creating a negative bias pressure on liquid to be aerosolized is present. The system may include means for receiving liquid; means for storing liquid; means for sealing the stored liquid in a sealed environment; means for maintaining an ambient pressure on the stored liquid while the stored liquid is being sealed; means for maintaining the ambient pressure in the sealed environment until a portion of the liquid is dispensed; means for discharging liquid of the stored liquid to be aerosolized; means for aerosolizing liquid of the discharged liquid; and means for allowing a negative bias pressure to develop on the stored liquid and discharged liquid."
For more information, see this patent: Blakey, David Mark; Day, Richard Francis. Negatively Biased Sealed Nebulizers Systems and Methods. U.S. Patent Number 9084862, filed July 19, 2010, and published online on July 21, 2015. Patent URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=9084862.PN.&OS=PN/9084862RS=PN/9084862
Keywords for this news article include: NEKTAR THERAPEUTICS.
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