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4-Traders Homepage  >  Equities  >  Swiss Exchange  >  Novartis AG    NOVN   CH0012005267

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Novartis : Timely use of Novartis' Entresto could prevent or postpone over 28,000 US deaths per year among HFrEF patients, according to an expert analysis in...

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06/30/2016 | 11:55pm CEST

Timely use of Novartis' Entresto could prevent or postpone over 28,000 US deaths per year among HFrEF patients, according to an expert analysis in JAMA Cardiology

By a News Reporter-Staff News Editor at Drug Week -- A new analysis published in JAMA Cardiology has found that timely and broad adoption of Entresto® (sacubitril/valsartan) by all eligible heart failure patients with reduced ejection fraction (HFrEF) could prevent or postpone more than 28,000 deaths each year in the US alone.(1) This analysis, based on an application of the results of PARADIGM-HF to published heart failure statistics, is the first to quantify the possible impact of Entresto's potential benefit in reducing death.(1)

Heart failure is a chronic condition that contributes to more than 300,000 deaths in the US every year.(4) About half of people with heart failure have HFrEF.(5) This new analysis estimates that as many as 28,484 deaths in HFrEF patients annually could be prevented or postponed with optimal use of Entresto (with sensitivity analyses demonstrating a range of 18,230 to 41,017).(1)

Further, the study suggests that delaying routine use of Entresto in clinical practice could have a substantial negative effect on patients, given the expected risk-benefit profile, as it could result in failure to prevent tens of thousands of deaths.(1) These findings demonstrate the significant survival benefits Entresto could offer to those living with HFrEF, if patients in the group defined by the authors were given access to treatment.(1) The study authors stated that nearly 84% of HFrEF patients - 2.2 million people - may be candidates for treatment with Entresto.(1)

Heart failure is a life-threatening condition and despite available medicines, about half of patients diagnosed with heart failure die within 5 years.(4,6,7) According to the study authors, these findings may substantially impact the national health of the HFrEF population, offering significant clinical benefit in preventing or postponing death when applied in clinical practice.(1)

"This expert analysis adds to the already compelling case for the treatment of heart failure patients with reduced ejection fraction with Entresto," said Fabrice Chouraqui, president of Novartis Pharmaceuticals Corporation. "In addition to survival benefits, the study also recognizes other treatment effects of Entresto, particularly in reducing HF hospitalizations.(1) Coupled with the recent Class I recommendation, the strongest endorsement, in the focused update to the US HF Guideline,(2) these findings underscore the potential of Entresto as a standard therapy for chronic HFrEF patients."

In a separate analysis published in the same issue of JAMA Cardiology, researchers used data from the PARADIGM-HF trial to model the health consequences and cost-effectiveness of Entresto over a 30-year time period.(3) They compared Entresto to the ACE-inhibitor enalapril and found Entresto was associated with more than a year longer average survival time, and that it was cost-effective compared to enalapril when these medications were used with other standard of care therapies.(3) For every 1,000 patients treated with Entresto vs. enalapril, potentially 59.7 HF hospital admissions could be averted per each year alive in the model.(3) In addition, Entresto increased life expectancy at an incremental cost-effectiveness ratio consistent with other high-value widely accepted cardiovascular interventions such as implantable cardioverter defibrillators (ICDs) and cholesterol-lowering statins before they became generic.(3)

Keywords for this news article include: Antihypertensive, Novartis Pharmaceuticals Corporation, Pharmaceutical Companies, Drugs, Therapy, Enalapril, Cardiology, Dipeptides, Novartis AG, Heart Disease, Heart Failure, Cardiovascular Agents, Cardiovascular Diseases, Heart Disorders and Diseases, Angiotensin-Converting Enzyme Inhibitor (see also Pharmaceutical Companies).

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2016, NewsRx LLC

(c) 2016 NewsRx LLC, source Health Newsletters

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