- First Patient Dosed in an Open-Label Study in Ophthotech's Anti-Fibrosis Program -

- Fovista® Combination Therapy Phase 2b Subgroup Analysis for Reduction of Sub-retinal Fibrosis to be Presented at the 2014 Annual Meeting of the American Academy of Ophthalmology -

NEW YORK--(BUSINESS WIRE)-- Ophthotech Corporation announced today the initiation of the first of several planned expansion trials, in addition to the ongoing Fovista® combination therapy Phase 3 clinical program. These expansion trials will investigate the potential role of Fovista® combination therapy in reducing sub-retinal fibrosis, addressing sub-optimal treatment response and reducing treatment burden in wet age-related macular degeneration (AMD) patients receiving anti-vascular endothelial growth factor (anti-VEGF) monotherapy. The first expansion trial is a Phase 2a open-label study investigating the potential role of anti-platelet derived growth factor (anti-PDGF) therapy in combination with anti-VEGF therapy in reducing sub-retinal fibrosis in wet AMD patients.

"The initiation of the Fovista® expansion studies continues our commitment to advance scientifically-driven therapeutic options to address an unmet medical need in age-related macular degeneration," stated David R. Guyer, M.D., Chief Executive Officer and Chairman of the Board of Ophthotech. "Today, we are pleased to announce the launch of the first study in our expansion trial program investigating the potential effect of administration of Fovista® in combination with an anti-VEGF agent on sub-retinal fibrosis in wet AMD patients. Sub-retinal fibrosis is associated with poor visual outcome in patients receiving anti-VEGF monotherapy for wet AMD. The inhibition of fibrosis is an urgent and unmet medical need in wet AMD."

"Multiple independently published studies have shown that, over time, sub-retinal fibrosis is commonly associated with vision loss in wet AMD patients receiving anti-VEGF monotherapy," stated Samir Patel, M.D., President of Ophthotech. "Peer-reviewed studies also indicate that PDGF is a significant mediator of retinal and organ fibrosis. Coupled with the findings from the retrospective evaluation from our randomized controlled Phase 2b trial, we believe these third party studies provide a strong rationale to investigate whether Fovista® (1.5mg) combination therapy can reduce sub-retinal fibrosis in patients with poor visual outcome, compared to anti-VEGF monotherapy. We are designing the anti-fibrosis expansion trials to provide further information to support the potential use of Fovista® combination therapyfor reduction of long term visual loss in wet AMD patients."

The Company also announced that a subgroup analysis showing a reduction of sub-retinal fibrosis and neovascular growth in patients receiving Fovista® (1.5mg) and Lucentis® in the Company's Phase 2b trial has been accepted as an oral presentation at this year's Annual Meeting of the American Academy of Ophthalmology, one of the major medical meetings for retinal physicians. A featured oral presentation entitled, "Dual Antagonism of Platelet Derived Growth Factor (Fovista® 1.5 mg) and Vascular Endothelial Growth Factor (Lucentis® 0.5 mg) Results in Reduced Sub-retinal Fibrosis and Neovascular Growth" is scheduled to be presented on October 21, 2014, at the 2014 American Academy of Ophthalmology meeting being held in Chicago, IL.

Fovista®Phase 3 Program

The Fovista® Phase 3 program consists of three clinical trials to evaluate the safety and efficacy of Fovista

distributed by