List price increases were calculated using data from Truven Health Analytics and do not reflect rebates and discounts negotiated with insurers. U.S. revenue was based on company reports.

AbbVie Inc (>> AbbVie Inc) increased the price of Humira, an injectible drug, by 126 percent for a typical monthly treatment to $3,797.10, compared with $1,676.98 on Dec. 31, 2010. The drug had $8.4 billion in U.S. sales in 2015 versus $6.5 billion in 2014.

Amgen raised the list price of Enbrel by 118 percent to $932.16 for a typical weekly treatment from $427.24 on Dec. 31, 2010, including three increases last year. It had U.S. sales of $5.1 billion in 2015, up from $4.4 billion a year earlier.

Teva Pharmaceutical Industries Ltd (>> Teva Pharmaceutical Industries Limited) raised the price of multiple sclerosis drug Copaxone by 118 percent, pushing its monthly price to $6,593.00 from $3,025.04 on Dec. 31, 2010. It had U.S. sales of $4.0 billion in 2015 versus $4.2 billion in 2014.

    

AstraZeneca Plc (>> AstraZeneca plc) increased the price of cholesterol fighter Crestor's three-month supply by 113 percent to $745.41 from $350.17. Sales fell about 3 percent to $2.84 billion in 2015. 

Otsuka Pharmaceutical Co Ltd (>> Otsuka Holdings Co Ltd) raised the list price by 96 percent for a typical monthly supply of depression drug Abilify to $891.97, up from $454.07 on Dec. 31, 2010. U.S. sales were not available.

Sanofi SA (>> Sanofi) raised the list price of Lantus Solostar, an insulin glargine product used to treat diabetes by 94 percent for 5 pen devices to $372.76, up from $191.96 on Dec. 31, 2010. Its list price has not changed since the end of 2014. Total U.S. sales of Lantus, which includes other delivery mechanisms in addition to Solostar, fell 20 percent to 4 billion euros ($4.55 billion) in 2015 from a year earlier.

GlaxoSmithKline Plc's (>> GlaxoSmithKline plc) asthma treatment Advair Diskus inhalation disks for a 30-day supply rose to $334.63, up 67 percent from $199.90 on Dec. 31, 2010. Advair, which includes other delivery mechanisms in addition to disks, had 2015 U.S. sales of $2.85 billion, a decline of 13 percent.

Johnson & Johnson's (>> Johnson & Johnson) arthritis treatment Remicade, which is administered as an infusion typically every 4 to 8 weeks, increased 63 percent to $1,071.48 from $657.87 on Dec. 31, 2010 per treatment. Remicade U.S. sales rose 7 percent to $4.45 billion in 2015.

Amgen Inc's (>> Amgen, Inc.) Neulasta, an injectible drug used to prevent infection in chemotherapy patients, rose 55 percent to $5,155.65 per treatment from $3,320 on Dec. 31, 2010. Its 2015 U.S. sales were $3.89 billion versus $3.65 billion.

AstraZeneca Plc's (>> AstraZeneca plc) Nexium treatment for acid reflux sold as a monthly supply rose 54 percent to $250.94 from $162.55 on Dec. 31, 2010. Nexium had U.S. sales of $2.5 billion in 2015, down 32 percent from a year earlier.

($1 = 0.8788 euros)

(Reporting by Caroline Humer; Editing by Michele Gershberg and Lisa Girion)

By Caroline Humer