LONDON--(BUSINESS WIRE)--

FORM 8.3

AMENDMENT TO SALES

PUBLIC OPENING POSITION DISCLOSURE/DEALING DISCLOSURE BY

A PERSON WITH INTERESTS IN RELEVANT SECURITIES REPRESENTING 1% OR MORE

Rule 8.3 of the Takeover Code (the 'Code')

1. KEY INFORMATION

(a) Full name of discloser: Barclays PLC.
(b) Owner or controller of interest and short
positions disclosed, if different from 1(a):
(c) Name of offeror/offeree in relation to whose SHIRE PLC
relevant securities this form relates:
(d) If an exempt fund manager connected with an
offeror/offeree, state this and specify identity of
offeror/offeree:
(e) Date position held/dealing undertaken: 12 June 2018
(f) In addition to the company in 1(c) above, is the discloser making YES:
disclosures in respect of any other party to the offer? TAKEDA PHARMACEUTICAL CO LTD

2. POSITIONS OF THE PERSON MAKING THE DISCLOSURE

If there are positions or rights to subscribe to disclose in more than one class of relevant securities of the offeror or offeree named in 1(c), copy table 2(a) or (b) (as appropriate) for each additional class of relevant security.

(a) Interests and short positions in the relevant securities of the offeror or offeree to which the disclosure relates following the dealing (if any)

Class of relevant security: 5p ordinary
Interests Short Positions
Number (%) Number (%)
(1) Relevant securities owned
and/or controlled: 9,786,700 1.07% 3,932,639 0.43%
(2) Cash-settled derivatives:
267,575 0.03% 5,181,461 0.57%
(3) Stock-settled derivatives (including options)
and agreements to purchase/sell: 424,300 0.05% 578,800 0.06%
(4)
TOTAL: 10,478,575 1.15% 9,692,900 1.06%

All interests and all short positions should be disclosed.

Details of any open stock-settled derivative positions (including traded options), or agreements to purchase or sell relevant securities, should be given on a Supplemental Form 8 (Open Positions).

(b) Rights to subscribe for new securities (including directors' and other employee options)

Class of relevant security in relation to which subscription right exists:
Details, including nature of the rights concerned and relevant percentages:

3. DEALINGS (IF ANY) BY THE PERSON MAKING THE DISCLOSURE

Where there have been dealings in more than one class of relevant securities of the offeror or offeree named in 1(c), copy table 3(a), (b), (c) or (d) (as appropriate) for each additional class of relevant security dealt in.

The currency of all prices and other monetary amounts should be stated.

(a) Purchases and sales

Class of relevant Purchase/sale Number of Price per unit
security securities
ADR Purchase 6 161.0200 USD
ADR Purchase 14 160.3900 USD
ADR Purchase 52 160.8100 USD
ADR Purchase 100 160.8300 USD
ADR Purchase 100 160.7100 USD
ADR Purchase 103 160.8291 USD
ADR Purchase 129 160.7223 USD
ADR Purchase 165 160.5424 USD
ADR Purchase 200 161.1250 USD
ADR Purchase 212 160.8620 USD
5p ordinary Purchase 220 40.1050 GBP
5p ordinary Purchase 282 40.0993 GBP
5p ordinary Purchase 284 40.0538 GBP
ADR Purchase 300 160.8050 USD
5p ordinary Purchase 305 40.1156 GBP
5p ordinary Purchase 313 40.1508 GBP
5p ordinary Purchase 435 40.1016 GBP
5p ordinary Purchase 454 40.1329 GBP
5p ordinary Purchase 456 40.1700 GBP
5p ordinary Purchase 477 40.2786 GBP
ADR Purchase 500 161.1300 USD
ADR Purchase 500 160.9030 USD
5p ordinary Purchase 500 40.2838 GBP
ADR Purchase 558 160.5000 USD
ADR Purchase 700 161.1292 USD
ADR Purchase 937 160.8987 USD
ADR Purchase 1,084 160.9451 USD
ADR Purchase 1,384 160.7467 USD
ADR Purchase 1,500 160.8000 USD
ADR Purchase 1,900 160.8271 USD
ADR Purchase 1,944 160.7932 USD
5p ordinary Purchase 2,099 40.1524 GBP
ADR Purchase 2,400 160.6817 USD
ADR Purchase 2,652 160.9231 USD
ADR Purchase 2,700 160.4123 USD
5p ordinary Purchase 2,866 40.0864 GBP
ADR Purchase 3,072 160.9465 USD
5p ordinary Purchase 3,366 40.1560 GBP
ADR Purchase 3,830 160.7993 USD
5p ordinary Purchase 5,790 40.0000 GBP
ADR Purchase 6,267 160.8281 USD
5p ordinary Purchase 7,466 40.1305 GBP
5p ordinary Purchase 12,839 40.1801 GBP
5p ordinary Purchase 20,007 40.1015 GBP
ADR Purchase 23,662 160.8398 USD
5p ordinary Purchase 28,214 40.0932 GBP
ADR Purchase 62,000 160.7499 USD
5p ordinary Purchase 116,261 40.0228 GBP
ADR Sale 3 160.8000 USD
ADR Sale 10 160.4000 USD
ADR Sale 14 160.3900 USD
5p ordinary Sale 70 40.1550 GBP
5p ordinary Sale 74 40.1250 GBP
ADR Sale 100 160.9400 USD
ADR Sale 100 160.8300 USD
ADR Sale 100 160.3800 USD
ADR Sale 100 160.4100 USD
5p ordinary Sale 148 40.1145 GBP
ADR Sale 152 160.8034 USD
ADR Sale 154 160.5202 USD
ADR Sale 165 160.5424 USD
ADR Sale 200 160.4701 USD
ADR Sale 200 160.3450 USD
ADR Sale 200 160.6637 USD
5p ordinary Sale 207 40.0542 GBP
5p ordinary Sale 220 40.1050 GBP
5p ordinary Sale 226 40.0320 GBP
ADR Sale 290 160.5000 USD
ADR Sale 300 160.9833 USD
ADR Sale 300 161.1200 USD
5p ordinary Sale 347 40.0957 GBP
5p ordinary Sale 382 40.1666 GBP
ADR Sale 400 160.8562 USD
ADR Sale 400 160.7050 USD
ADR Sale 400 160.3950 USD
5p ordinary Sale 440 40.1100 GBP
5p ordinary Sale 469 40.0788 GBP
ADR Sale 600 160.4300 USD
ADR Sale 637 160.7709 USD
5p ordinary Sale 700 40.1164 GBP
5p ordinary Sale 721 40.1475 GBP
5p ordinary Sale 966 40.1482 GBP
ADR Sale 1,300 160.4069 USD
ADR Sale 1,400 161.1289 USD
ADR Sale 1,500 160.8193 USD
5p ordinary Sale 1,752 40.2421 GBP
5p ordinary Sale 1,860 40.1656 GBP
ADR Sale 1,900 160.4268 USD
ADR Sale 2,000 160.6310 USD
5p ordinary Sale 2,145 40.0000 GBP
ADR Sale 2,177 160.6369 USD
ADR Sale 2,200 160.6889 USD
5p ordinary Sale 2,364 40.0568 GBP
5p ordinary Sale 2,425 40.0998 GBP
ADR Sale 2,700 160.4123 USD
5p ordinary Sale 3,061 40.1468 GBP
ADR Sale 3,072 160.9465 USD
5p ordinary Sale 3,116 40.1864 GBP
5p ordinary Sale 3,125 40.1846 GBP
5p ordinary Sale 3,248 40.1241 GBP
ADR Sale 3,300 160.8845 USD
5p ordinary Sale 4,559 40.1371 GBP
5p ordinary Sale 4,701 40.1201 GBP
5p ordinary Sale 4,959 40.1288 GBP
5p ordinary Sale 5,806 40.1596 GBP
ADR Sale 6,826 160.4341 USD
5p ordinary Sale 7,502 40.0842 GBP
5p ordinary Sale 8,062 40.1021 GBP
5p ordinary Sale 9,933 40.0181 GBP
5p ordinary Sale 11,217 40.0173 GBP
5p ordinary Sale 25,223 40.1568 GBP
ADR Sale 38,135 160.8328 USD
5p ordinary Sale 55,677 40.0217 GBP
ADR Sale 62,500 160.7496 USD
5p ordinary Sale 67,835 40.0257 GBP

(b) Cash-settled derivative transactions

Class of Product Nature of dealing Number of Price per
relevant description reference unit
security securities
5p ordinary SWAP Long 143 40.1146 GBP
5p ordinary SWAP Long 666 40.2626 GBP
5p ordinary CFD Long 1,752 40.2421 GBP
5p ordinary SWAP Long 2,395 40.1702 GBP
5p ordinary CFD Long 2,425 40.0998 GBP
5p ordinary CFD Long 3,000 40.0214 GBP
5p ordinary CFD Long 3,116 40.1864 GBP
5p ordinary CFD Long 3,201 40.1024 GBP
5p ordinary CFD Long 4,959 40.1288 GBP
5p ordinary SWAP Long 5,060 40.2835 GBP
5p ordinary SWAP Long 6,800 39.9960 GBP
5p ordinary CFD Long 27,591 39.9963 GBP
5p ordinary CFD Long 32,972 39.9968 GBP
5p ordinary CFD Short 12 40.1158 GBP
5p ordinary SWAP Short 18 40.1400 GBP
5p ordinary SWAP Short 20 40.1100 GBP
5p ordinary SWAP Short 36 40.0600 GBP
5p ordinary CFD Short 54 40.1155 GBP
5p ordinary SWAP Short 83 40.0955 GBP
5p ordinary SWAP Short 88 40.1254 GBP
5p ordinary SWAP Short 137 40.1404 GBP
5p ordinary CFD Short 239 40.1156 GBP
5p ordinary CFD Short 282 40.0993 GBP
5p ordinary CFD Short 339 40.0989 GBP
5p ordinary SWAP Short 530 40.0839 GBP
5p ordinary CFD Short 1,011 40.1031 GBP
5p ordinary CFD Short 1,536 40.2005 GBP
5p ordinary CFD Short 3,250 40.3063 GBP
5p ordinary CFD Short 3,464 40.0598 GBP
5p ordinary CFD Short 4,250 40.1806 GBP
5p ordinary SWAP Short 5,869 40.0004 GBP
5p ordinary SWAP Short 11,767 40.0000 GBP
5p ordinary SWAP Short 15,328 40.0154 GBP
5p ordinary SWAP Short 42,713 40.0537 GBP

(c) Stock-settled derivative transactions (including options)

(i) Writing, selling, purchasing or varying

Class Product Writing, Number Exercise Type Expiry Option
of description purchasing, of price date money
relevant selling, securities per unit paid/
security varying etc to which received
option per unit
relates
ADR Call Options Purchasing 14,900 168 USD American 29 Jun 2018 0.6006 USD
ADR Call Options Purchasing 400 170 USD American 20 Jul 2018 1.0550 USD

(ii) Exercise

Class of relevant security Product description

e.g. call option

Exercising/ exercised against Number of securities Exercise price per unit

(d) Other dealings (including subscribing for new securities)

Class of relevant security Nature of dealing

e.g. subscription, conversion

Details Price per unit (if applicable)

4. OTHER INFORMATION

(a) Indemnity and other dealing arrangements

Details of any indemnity or option arrangement, or any agreement or understanding, formal or informal, relating to relevant securities which may be an inducement to deal or refrain from dealing entered into by the person making the disclosure and any party to the offer or any person acting in concert with a party to the offer:

Irrevocable commitments and letters of intent should not be included. If there are no such agreements, arrangements or understandings, state 'none'

None

(b) Agreements, arrangements or understandings relating to options or derivatives

Details of any agreement, arrangement or understanding, formal or informal, between the person making the disclosure and any other person relating to:

(i) the voting rights of any relevant securities under any option; or

(ii) the voting rights or future acquisition or disposal of any relevant securities to which any derivative is referenced:

If there are no such agreements, arrangements or understandings, state 'none'

None

(c) Attachments

Is a Supplemental Form 8 (Open Positions) attached? YES
Date of disclosure: 19 Jun 2018
Contact name: Jay Supaya
Telephone number: 020 7773 0635

Public disclosures under Rule 8 of the Code must be made to a Regulatory Information Service.

The Panel's Market Surveillance Unit is available for consultation in relation to the Code's disclosure requirements on +44 (0)20 7638 0129.

The Code can be viewed on the Panel's website atwww.thetakeoverpanel.org.uk.

SUPPLEMENTAL FORM 8 (OPEN POSITIONS)

DETAILS OF OPEN STOCK-SETTLED DERIVATIVE (INCLUDING OPTION) POSITIONS, AGREEMENTS TO PURCHASE OR SELL ETC.

Note 5(i) on Rule 8 of the Takeover Code (the 'Code')

1. KEY INFORMATION

Identity of the person whose positions/dealings Barclays PLC.
are being disclosed:
Name of offeror/offeree in relation to whose SHIRE PLC
relevant securities this from relates:

2. STOCK-SETTLED DERIVATIVES (INCLUDING OPTIONS)

Class Product Writing, Number Exercise Type Expiry
of description purchasing, of price date
relevant selling, securities per unit
security varying etc to which
option
relates
5p ordinary Call Options Written -125,000 3600.0000 American 21 Dec 2018
5p ordinary Call Options Purchased 100,000 4000.0000 American 15 Jun 2018
5p ordinary Call Options Purchased 10,000 4200.0000 American 15 Jun 2018
5p ordinary Put Options Purchased -140,000 3500.0000 American 15 Jun 2018
5p ordinary Put Options Written 125,000 3600.0000 American 21 Dec 2018
ADR Call Options Purchased 20,700 175.0000 American 20 Jul 2018
ADR Put Options Written 2,100 140.0000 American 20 Jul 2018
ADR Call Options Purchased 1,700 195.0000 American 17 Jan 2020
ADR Call Options Purchased 1,000 180.0000 American 17 Jan 2020
ADR Call Options Purchased 1,000 170.0000 American 17 Jan 2020
ADR Call Options Purchased 1,000 168.0000 American 15 Jun 2018
ADR Call Options Purchased 200 135.0000 American 17 Jan 2020
ADR Call Options Purchased 100 175.0000 American 18 Jan 2019
ADR Put Options Written 100 110.0000 American 17 Jan 2020
ADR Put Options Purchased -400 165.0000 American 17 Jan 2020
ADR Put Options Purchased -700 160.0000 American 17 Jan 2020
ADR Put Options Purchased -1,000 150.0000 American 18 Jan 2019
ADR Put Options Purchased -1,500 165.0000 American 18 Jan 2019
ADR Put Options Purchased -2,600 160.0000 American 20 Jul 2018
ADR Put Options Purchased -2,700 80.0000 American 18 Jan 2019
ADR Put Options Purchased -5,800 180.0000 American 18 Jan 2019
ADR Put Options Purchased -7,700 130.0000 American 18 Jan 2019
ADR Put Options Purchased -22,500 170.0000 American 15 Jun 2018
ADR Put Options Purchased -44,000 145.0000 American 19 Oct 2018
ADR Call Options Purchased 1,600 170.0000 American 19 Oct 2018
ADR Call Options Written -100 125.0000 American 20 Jul 2018
ADR Put Options Written 22,700 155.0000 American 20 Jul 2018
ADR Call Options Purchased 14,900 168.0000 American 29 Jun 2018
ADR Call Options Purchased 13,500 170.0000 American 15 Jun 2018
ADR Call Options Purchased 3,600 185.0000 American 19 Oct 2018
ADR Call Options Purchased 3,100 155.0000 American 18 Jan 2019
ADR Put Options Written 2,900 95.0000 American 20 Jul 2018
ADR Put Options Written 1,000 90.0000 American 18 Jan 2019
ADR Call Options Purchased 600 125.0000 American 18 Jan 2019
ADR Call Options Purchased 400 230.0000 American 18 Jan 2019
ADR Call Options Purchased 300 115.0000 American 18 Jan 2019
ADR Put Options Written 200 200.0000 American 17 Jan 2020
ADR Put Options Written 200 125.0000 American 19 Oct 2018
ADR Put Options Written 200 135.0000 American 20 Jul 2018
ADR Call Options Purchased 100 220.0000 American 18 Jan 2019
ADR Call Options Purchased 100 165.0000 American 15 Jun 2018
ADR Put Options Written 100 95.0000 American 18 Jan 2019
ADR Put Options Purchased -100 120.0000 American 20 Jul 2018
ADR Call Options Written -100 140.0000 American 17 Jan 2020
ADR Call Options Written -400 173.0000 American 22 Jun 2018
ADR Call Options Written -900 145.0000 American 20 Jul 2018
ADR Call Options Written -1,000 85.0000 American 18 Jan 2019
ADR Call Options Written -1,600 145.0000 American 18 Jan 2019
ADR Put Options Purchased -2,200 110.0000 American 20 Jul 2018
ADR Put Options Purchased -2,500 120.0000 American 17 Jan 2020
ADR Call Options Purchased 4,500 200.0000 American 18 Jan 2019
ADR Call Options Purchased 5,800 165.0000 American 20 Jul 2018
ADR Call Options Purchased 200 155.0000 American 17 Jan 2020
ADR Call Options Purchased 200 130.0000 American 17 Jan 2020
ADR Call Options Written -100 163.0000 American 15 Jun 2018
ADR Put Options Purchased -200 170.0000 American 18 Jan 2019
ADR Call Options Written -400 115.0000 American 20 Jul 2018
ADR Call Options Written -600 175.0000 American 19 Oct 2018
ADR Put Options Purchased -800 150.0000 American 17 Jan 2020
ADR Call Options Written -1,500 148.0000 American 22 Jun 2018
ADR Call Options Purchased 12,500 163.0000 American 15 Jun 2018
ADR Call Options Purchased 2,200 185.0000 American 18 Jan 2019
ADR Call Options Purchased 500 195.0000 American 18 Jan 2019
ADR Put Options Written 500 125.0000 American 20 Jul 2018
ADR Call Options Purchased 400 165.0000 American 18 Jan 2019
ADR Call Options Purchased 200 120.0000 American 17 Jan 2020
ADR Call Options Purchased 100 173.0000 American 15 Jun 2018
ADR Put Options Purchased -200 115.0000 American 19 Oct 2018
ADR Put Options Purchased -1,000 105.0000 American 18 Jan 2019
ADR Put Options Purchased -1,200 115.0000 American 20 Jul 2018
ADR Call Options Written -8,000 180.0000 American 18 Jan 2019
ADR Call Options Written -162,000 165.0000 American 15 Jun 2018
ADR Call Options Purchased 1,500 140.0000 American 20 Jul 2018
ADR Call Options Purchased 1,100 170.0000 American 18 Jan 2019
ADR Call Options Purchased 200 160.0000 American 17 Jan 2020
ADR Put Options Purchased -100 150.0000 American 20 Jul 2018
ADR Call Options Written -100 130.0000 American 18 Jan 2019
ADR Call Options Written -300 150.0000 American 20 Jul 2018
ADR Put Options Purchased -500 140.0000 American 17 Jan 2020
ADR Put Options Purchased -1,000 80.0000 American 17 Jan 2020
ADR Put Options Purchased -2,300 85.0000 American 18 Jan 2019
ADR Call Options Written -3,800 170.0000 American 20 Jul 2018
ADR Put Options Purchased -6,000 135.0000 American 18 Jan 2019
ADR Put Options Purchased -7,500 155.0000 American 18 Jan 2019
ADR Call Options Purchased 37,200 160.0000 American 15 Jun 2018
ADR Call Options Purchased 7,500 160.0000 American 20 Jul 2018
ADR Call Options Purchased 4,200 180.0000 American 20 Jul 2018
ADR Put Options Written 2,800 120.0000 American 18 Jan 2019
ADR Call Options Purchased 600 165.0000 American 22 Jun 2018
ADR Call Options Purchased 100 110.0000 American 17 Jan 2020
ADR Call Options Purchased 100 140.0000 American 18 Jan 2019
ADR Put Options Written 100 140.0000 American 19 Oct 2018
ADR Put Options Purchased -1,100 140.0000 American 18 Jan 2019
ADR Put Options Purchased -2,000 175.0000 American 19 Oct 2018
ADR Put Options Purchased -2,100 160.0000 American 18 Jan 2019
ADR Put Options Purchased -3,700 145.0000 American 17 Jan 2020
ADR Call Options Purchased 4,100 135.0000 American 20 Jul 2018
ADR Put Options Written 4,100 150.0000 American 15 Jun 2018
ADR Call Options Purchased 2,000 150.0000 American 17 Jan 2020
ADR Call Options Purchased 1,000 135.0000 American 18 Jan 2019
ADR Put Options Written 700 85.0000 American 20 Jul 2018
ADR Call Options Purchased 500 150.0000 American 18 Jan 2019
ADR Call Options Purchased 400 185.0000 American 20 Jul 2018
ADR Put Options Written 200 70.0000 American 19 Oct 2018
ADR Put Options Written 200 145.0000 American 20 Jul 2018
ADR Put Options Written 100 110.0000 American 18 Jan 2019
ADR Put Options Written 100 75.0000 American 19 Oct 2018
ADR Put Options Purchased -500 145.0000 American 18 Jan 2019
ADR Put Options Purchased -1,000 170.0000 American 17 Jan 2020
ADR Put Options Purchased -1,200 135.0000 American 17 Jan 2020
ADR Put Options Purchased -1,800 115.0000 American 18 Jan 2019
ADR Put Options Purchased -2,400 75.0000 American 20 Jul 2018
ADR Call Options Written -2,600 175.0000 American 15 Jun 2018

3. AGREEMENTS TO PURCHASE OR SELL ETC.

Full details should be given so that the nature of the interest or position can be fully understood:

It is not necessary to provide details on a Supplemental Form (Open Positions) with regard to cash-settled derivatives.

The currency of all prices and other monetary amounts should be stated.

The Panel's Market Surveillance Unit is available for consultation in relation to the Code's disclosure requirements on +44 (0)20 7638 0129.

The Code can be viewed on the Panel's website atwww.thetakeoverpanel.org.uk.

View source version on businesswire.com:https://www.businesswire.com/news/home/20180619005662/en/

BARCLAYS PLC

Source: BARCLAYS PLC

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Shire plc published this content on 19 June 2018 and is solely responsible for the information contained herein. Distributed by Public, unedited and unaltered, on 19 June 2018 10:42:01 UTC