FORM 8.3

PUBLIC OPENING POSITION DISCLOSURE/DEALING DISCLOSURE BY

A PERSON WITH INTERESTS IN RELEVANT SECURITIES REPRESENTING 1% OR MORE

Rule 8.3 of the Takeover Code (the 'Code')

1. KEY INFORMATION

(a) Full name of discloser:

Société Générale S.A.

(b) Owner or controller of interests and short positions disclosed, if different from 1(a):

The naming of nominee or vehicle companies is insufficient. For a trust, the trustee(s), settlor and beneficiaries must be named.

(c) Name of offeror/offeree in relation to whose relevant securities this form relates:

Use a separate form for each offeror/offeree

Shire Plc

(d) If an exempt fund manager connected with an offeror/offeree, state this and specify identity of offeror/offeree:

(e) Date position held/dealing undertaken:

For an opening position disclosure, state the latest practicable date prior to the disclosure

19/07/2018

(f) In addition to the company in 1(c) above, is the discloser making disclosures in respect of any other party to the offer?

If it is a cash offer or possible cash offer, state 'N/A'

YES: Takeda Pharmaceutical Company Limited

2. POSITIONS OF THE PERSON MAKING THE DISCLOSURE

If there are positions or rights to subscribe to disclose in more than one class of relevant securities of the offeror or offeree named in 1(c), copy table 2(a) or (b) (as appropriate) for each additional class of relevant security.

(a) Interests and short positions in the relevant securities of the offeror or offeree to which the disclosure relates following the dealing (if any)

Class of relevant security:

Ordinary shares: 13,910,925 Shares Interests and 573,508 short position

ADR(referencing the ordinary): 674,760 equivalent Shares interests and 13,335 equivalent Shares as short position

Where (1 ADR = 3 ordinary shares)

Interests

Short positions

Number

%

Number

%

(1) Relevant securities owned and/or controlled:

14,585,685

1.60

586,843

0.06

(2) Cash-settled derivatives:

195,395

0.02

11,513,013

1.26

(3) Stock-settled derivatives (including options) and agreements to purchase/sell:

275,000

0.03

150,000

0.02

TOTAL:

15,056,080

1.65

12,249,856

1.34

All interests and all short positions should be disclosed.

Details of any open stock-settled derivative positions (including traded options), or agreements to purchase or sell relevant securities, should be given on a Supplemental Form 8 (Open Positions).

(b) Rights to subscribe for new securities (including directors' and other employee options)

Class of relevant security in relation to which subscription right exists:

Details, including nature of the rights concerned and relevant percentages:

3. DEALINGS (IF ANY) BY THE PERSON MAKING THE DISCLOSURE

Where there have been dealings in more than one class of relevant securities of the offeror or offeree named in 1(c), copy table 3(a), (b), (c) or (d) (as appropriate) for each additional class of relevant security dealt in.

The currency of all prices and other monetary amounts should be stated.

(a) Purchases and sales

Class of relevant security

Purchase/sale

Number of securities

Price per unit

GBP

Ordinary

Purchase

199

44.235

Ordinary

Purchase

125

44.08

Ordinary

Purchase

37

44.315

Ordinary

Purchase

54

44.315

Ordinary

Purchase

104

44.1

Ordinary

Purchase

23

44.1

Ordinary

Purchase

164

44.205

Ordinary

Purchase

203

44.215

Ordinary

Purchase

422

44.3

Ordinary

Purchase

330

44.125

Ordinary

Purchase

86

44.125

Ordinary

Purchase

23

44.12

Ordinary

Purchase

187

44.15

Ordinary

Purchase

91

44.15

Ordinary

Purchase

125

44.16

Ordinary

Purchase

23

44.125

Ordinary

Purchase

223

44.24

Ordinary

Purchase

79

44.26

Ordinary

Purchase

71

44.115

Ordinary

Purchase

110

44.115

Ordinary

Purchase

105

44.115

Ordinary

Purchase

52

44.245

Ordinary

Purchase

88

44.24

Ordinary

Purchase

183

44.2

Ordinary

Purchase

227

44.17

Ordinary

Purchase

82

44.285

Ordinary

Purchase

97

44.045

Ordinary

Purchase

55

44.285

Ordinary

Purchase

73

44.18

Ordinary

Purchase

61

44.05

Ordinary

Purchase

70

44.2

Ordinary

Purchase

228

44.27

Ordinary

Purchase

108

44.12

Ordinary

Purchase

13

44.315

Ordinary

Purchase

40

44.315

Ordinary

Purchase

116

44.2

Ordinary

Purchase

72

44.2

Ordinary

Purchase

185

44.215

Ordinary

Purchase

125

44.22

Ordinary

Purchase

116

44.22

Ordinary

Purchase

95

44.28

Ordinary

Purchase

140

44.31

Ordinary

Purchase

125

44.315

Ordinary

Purchase

17

44.31

Ordinary

Purchase

200

44.25

Ordinary

Purchase

109

44.26

Ordinary

Purchase

107

44.235

Ordinary

Purchase

57

44.1

Ordinary

Purchase

100

44.3

Ordinary

Purchase

100

44.21

Ordinary

Purchase

242

44.135

Ordinary

Purchase

100

44.24

Ordinary

Purchase

63

44.235

Ordinary

Purchase

59

44.3

Ordinary

Purchase

57

44.27

Ordinary

Purchase

33

44.115

Ordinary

Purchase

172

44.115

Ordinary

Purchase

176

44.16

Ordinary

Purchase

69

44.13

Ordinary

Purchase

201

44.115

Ordinary

Purchase

293

44.07

Ordinary

Purchase

84

44.305

Ordinary

Purchase

60

44.095

Ordinary

Purchase

104

44.17

Ordinary

Purchase

237

44.045

Ordinary

Purchase

90

44.305

Ordinary

Purchase

70

44.305

Ordinary

Purchase

57

44.255

Ordinary

Purchase

64

44.12

Ordinary

Purchase

161

44.2

Ordinary

Purchase

180

44.005

Ordinary

Purchase

63

44.23

Ordinary

Purchase

100

44.23

Ordinary

Purchase

142

44.31

Ordinary

Purchase

100

44.305

Ordinary

Purchase

30

44.25

Ordinary

Purchase

68

44.25

Ordinary

Purchase

210

44.25

Ordinary

Purchase

100

44.31

Ordinary

Purchase

23

44.225

Ordinary

Purchase

35

44.225

Ordinary

Purchase

13

44.495

Ordinary

Purchase

6

44.43

Ordinary

Purchase

1

44.455

Ordinary

Purchase

14

44.5

Ordinary

Purchase

8

44.5

Ordinary

Purchase

34

44.49

Ordinary

Purchase

84

44.505

Ordinary

Purchase

101

44.49

Ordinary

Purchase

5

44.435

Ordinary

Purchase

2

44.49

Ordinary

Purchase

99

44.5

Ordinary

Purchase

30

44.12

Ordinary

Purchase

72

44.235

Ordinary

Purchase

42

44.215

Ordinary

Purchase

335

44.235

Ordinary

Purchase

101

44.285

Ordinary

Purchase

201

44.08

Ordinary

Purchase

150

44.08

Ordinary

Purchase

354

44.075

Ordinary

Purchase

118

44.05

Ordinary

Purchase

102

44.105

Ordinary

Purchase

10

44.145

Ordinary

Purchase

101

44.245

Ordinary

Purchase

186

44.1

Ordinary

Purchase

101

44.28

Ordinary

Purchase

71

44.27

Ordinary

Purchase

30

44.27

Ordinary

Purchase

101

44.21

Ordinary

Purchase

12

44.3

Ordinary

Purchase

177

44.16

Ordinary

Purchase

150

44.135

Ordinary

Purchase

102

44.175

Ordinary

Purchase

101

44.22

Ordinary

Purchase

102

44.135

Ordinary

Purchase

43

44.11

Ordinary

Purchase

101

44.245

Ordinary

Purchase

102

44.23

Ordinary

Purchase

102

44.105

Ordinary

Purchase

149

44.2

Ordinary

Purchase

97

44.2

Ordinary

Purchase

41

44.2

Ordinary

Purchase

102

44.11

Ordinary

Purchase

101

44.25

Ordinary

Purchase

106

44.1

Ordinary

Purchase

84

44.25

Ordinary

Purchase

91

44.11

Ordinary

Purchase

11

44.11

Ordinary

Purchase

101

44.29

Ordinary

Purchase

150

44.145

Ordinary

Purchase

204

44.165

Ordinary

Purchase

101

44.18

Ordinary

Purchase

301

44.16

Ordinary

Purchase

228

44.16

Ordinary

Purchase

101

44.215

Ordinary

Purchase

101

44.235

Ordinary

Purchase

101

44.265

Ordinary

Purchase

90

44.195

Ordinary

Purchase

101

44.11

Ordinary

Purchase

102

44.105

Ordinary

Purchase

102

44.175

Ordinary

Purchase

289

44.17

Ordinary

Purchase

103

44.115

Ordinary

Purchase

288

44.18

Ordinary

Purchase

274

44.125

Ordinary

Purchase

188

44.045

Ordinary

Purchase

34

44.18

Ordinary

Purchase

101

44.255

Ordinary

Purchase

124

44.005

Ordinary

Purchase

124

44.005

Ordinary

Purchase

94

44.005

Ordinary

Purchase

104

44.225

Ordinary

Purchase

101

44.26

Ordinary

Purchase

34

44.275

Ordinary

Purchase

4

44.21

Ordinary

Purchase

254

44.21

Ordinary

Purchase

150

44.195

Ordinary

Purchase

101

44.28

Ordinary

Purchase

102

44.21

Ordinary

Purchase

101

44.19

Ordinary

Purchase

124

44.2

Ordinary

Purchase

41

44.18

Ordinary

Purchase

60

44.18

Ordinary

Purchase

101

44.23

Ordinary

Purchase

102

44.21

Ordinary

Purchase

91

44.21

Ordinary

Purchase

123

44.225

Ordinary

Purchase

150

44.2

Ordinary

Purchase

150

44.2

Ordinary

Purchase

146

44.225

Ordinary

Purchase

101

44.235

Ordinary

Purchase

102

44.1

Ordinary

Purchase

101

44.14

Ordinary

Purchase

102

44.135

Ordinary

Purchase

30

44.13

Ordinary

Purchase

71

44.13

Ordinary

Purchase

102

44.235

Ordinary

Purchase

9

44.24

Ordinary

Purchase

92

44.24

Ordinary

Purchase

150

44.135

Ordinary

Purchase

13

44.21

Ordinary

Purchase

78

44.445

Ordinary

Purchase

571

44.445

Ordinary

Purchase

2,240

44.445

Ordinary

Purchase

908

44.445

Ordinary

Purchase

437

44.445

Ordinary

Purchase

657

44.445

Ordinary

Purchase

634

44.445

Ordinary

Purchase

297

44.445

Ordinary

Purchase

634

44.445

Ordinary

Purchase

362

44.15

Ordinary

Purchase

50

44.17

Ordinary

Purchase

137

44.17

Ordinary

Purchase

69

44.17

Ordinary

Purchase

90

44.22

Ordinary

Purchase

90

44.31

Ordinary

Purchase

91

44.145

Ordinary

Purchase

67

44.275

Ordinary

Purchase

18

44.225

Ordinary

Purchase

160

44.22

Ordinary

Purchase

150

44.225

Ordinary

Purchase

114

44.23

Ordinary

Purchase

36

44.225

Ordinary

Purchase

210

44.225

Ordinary

Purchase

51

44.23

Ordinary

Purchase

179

44.225

Ordinary

Purchase

199

44.225

Ordinary

Purchase

145

44.225

Ordinary

Purchase

147

44.3

Ordinary

Purchase

68

44.3

Ordinary

Purchase

32

44.255

Ordinary

Purchase

128

44.255

Ordinary

Purchase

221

44.25

Ordinary

Purchase

147

44.25

Ordinary

Purchase

147

44.25

Ordinary

Purchase

74

44.16

Ordinary

Purchase

49

44.26

Ordinary

Purchase

150

44.26

Ordinary

Purchase

103

44.27

Ordinary

Purchase

150

44.265

Ordinary

Purchase

188

44.26

Ordinary

Purchase

29

44.26

Ordinary

Purchase

295

44.27

Ordinary

Purchase

157

44.26

Ordinary

Purchase

255

44.255

Ordinary

Purchase

150

44.17

Ordinary

Purchase

129

44.25

Ordinary

Purchase

241

44.25

Ordinary

Purchase

74

44.25

Ordinary

Purchase

58

44.25

Ordinary

Purchase

221

44.265

Ordinary

Purchase

150

44.285

Ordinary

Purchase

199

44.225

Ordinary

Purchase

130

44.265

Ordinary

Purchase

44

44.225

Ordinary

Purchase

47

44.17

Ordinary

Purchase

199

44.22

Ordinary

Purchase

177

44.245

Ordinary

Purchase

36

44.315

Ordinary

Purchase

86

44.275

Ordinary

Purchase

165

44.275

Ordinary

Purchase

43

44.475

Ordinary

Purchase

59

44.475

Ordinary

Purchase

46

44.435

Ordinary

Purchase

4

44.43

Ordinary

Purchase

28

44.43

Ordinary

Purchase

59

44.43

Ordinary

Purchase

14

44.495

Ordinary

Purchase

18

44.15

Ordinary

Purchase

125

44.495

Ordinary

Purchase

38

44.475

Ordinary

Purchase

39

44.48

Ordinary

Purchase

75

44.125

Ordinary

Purchase

4

44.435

Ordinary

Purchase

34

44.455

Ordinary

Purchase

45

44.485

Ordinary

Purchase

1

44.435

Ordinary

Purchase

3

44.435

Ordinary

Purchase

7

44.485

Ordinary

Purchase

76

44.495

Ordinary

Purchase

9

44.125

Ordinary

Purchase

66

44.495

Ordinary

Purchase

25,000

44.24952692

Class of relevant security

Purchase/sale

Number of securities

Price per unit

USD

ADR

Purchase

30

172.98

ADR

Purchase

1,560

173.02312

ADR

Purchase

1,299

172.8954

ADR

Purchase

723

173.09755

ADR

Purchase

1,089

172.87113

ADR

Purchase

24,225

173.02363

Class of relevant security

Purchase/sale

Number of securities

Price per unit

GBP

Ordinary

Sale

90

44.48

Ordinary

Sale

223

44.225

Ordinary

Sale

35

44.135

Ordinary

Sale

26

44.135

Ordinary

Sale

4

44.51

Ordinary

Sale

100

44.315

Ordinary

Sale

101

44.34

Ordinary

Sale

102

44.085

Ordinary

Sale

102

44.08

Ordinary

Sale

8

44.09

Ordinary

Sale

93

44.09

Ordinary

Sale

101

44.3

Ordinary

Sale

101

44.29

Ordinary

Sale

102

44.085

Ordinary

Sale

69

44.25

Ordinary

Sale

102

44.03

Ordinary

Sale

102

44.08

Ordinary

Sale

106

44.035

Ordinary

Sale

60

44.21

Ordinary

Sale

101

44.275

Ordinary

Sale

41

44.21

Ordinary

Sale

101

44.16

Ordinary

Sale

1,017

44.445

Ordinary

Sale

2,655

44.445

Ordinary

Sale

2,483

44.445

Ordinary

Sale

475

44.445

Ordinary

Sale

450

44.445

Ordinary

Sale

400

44.445

Ordinary

Sale

375

44.445

Ordinary

Sale

449

44.445

Ordinary

Sale

525

44.445

Ordinary

Sale

550

44.445

Ordinary

Sale

116

44.445

Ordinary

Sale

136

44.445

Ordinary

Sale

375

44.445

Ordinary

Sale

525

44.445

Ordinary

Sale

325

44.445

Ordinary

Sale

250

44.445

Ordinary

Sale

137

44.445

Ordinary

Sale

325

44.445

Ordinary

Sale

137

44.445

Ordinary

Sale

250

44.445

Ordinary

Sale

147

44.445

Ordinary

Sale

200

44.445

Ordinary

Sale

136

44.445

Ordinary

Sale

150

44.445

Ordinary

Sale

147

44.445

Ordinary

Sale

200

44.445

Ordinary

Sale

127

44.19

Ordinary

Sale

43

44.1

Ordinary

Sale

47

44.085

Ordinary

Sale

55

44.085

Ordinary

Sale

39

44.315

Ordinary

Sale

43

44.29

Ordinary

Sale

150

44.29

Ordinary

Sale

24

44.29

Ordinary

Sale

23

44.29

Ordinary

Sale

86

44.515

Ordinary

Sale

4

44.51

Ordinary

Sale

4

44.485

Ordinary

Sale

27,688

44.26

Ordinary

Sale

100

44.205

Ordinary

Sale

275

44.445

Class of relevant security

Purchase/sale

Number of securities

Price per unit

USD

ADR

Sale

600

172.495

ADR

Sale

3

173.3

ADR

Sale

21

172.98

ADR

Sale

7,467

172.99082

ADR

Sale

3

172.98

ADR

Sale

2,940

172.98

ADR

Sale

3,933

173.25314

Total Purchases

87,667

Total Sales

58,480

(b) Cash-settled derivative transactions

Class of relevant security

Product description

e.g. CFD

Nature of dealing

e.g. opening/closing a long/short position, increasing/reducing a long/short position

Number of reference securities

Price per unit GBP

Ordinary

CFD

Increasing a short position

25,000

44.24952692

Ordinary

Listed call warrant

Reducing a short position

100

8.950

Class of relevant security

Product description

e.g. CFD

Nature of dealing

e.g. opening/closing a long/short position, increasing/reducing a long/short position

Number of reference securities

Price per unit USD

ADR

CFD

Increasing a short position

8,075

173.02363

(c) Stock-settled derivative transactions (including options)

(i) Writing, selling, purchasing or varying

Class of relevant security

Product description e.g. call option

Writing, purchasing, selling, varying etc.

Number of securities to which option relates

Exercise price per unit

Type

e.g. American, European etc.

Expiry date

Option money paid/ received per unit GBP

(ii) Exercise

Class of relevant security

Product description

e.g. call option

Exercising/ exercised against

Number of securities

Exercise price per unit GBP

(d) Other dealings (including subscribing for new securities)

Class of relevant security

Nature of dealing

e.g. subscription, conversion

Details

Price per unit (if applicable) GBP

4. OTHER INFORMATION

(a) Indemnity and other dealing arrangements

Details of any indemnity or option arrangement, or any agreement or understanding, formal or informal, relating to relevant securities which may be an inducement to deal or refrain from dealing entered into by the person making the disclosure and any party to the offer or any person acting in concert with a party to the offer:

Irrevocable commitments and letters of intent should not be included. If there are no such agreements, arrangements or understandings, state 'none'

(b) Agreements, arrangements or understandings relating to options or derivatives

Details of any agreement, arrangement or understanding, formal or informal, between the person making the disclosure and any other person relating to:

(i) the voting rights of any relevant securities under any option; or

(ii) the voting rights or future acquisition or disposal of any relevant securities to which any derivative is referenced:

If there are no such agreements, arrangements or understandings, state 'none'

(c) Attachments

Is a Supplemental Form 8 (Open Positions) attached?

Yes

Date of disclosure:

20/07/2018

Contact name:

Olivier Vero

Telephone number:

+44 20 7676 6969

Public disclosures under Rule 8 of the Code must be made to a Regulatory Information Service.

The Panel's Market Surveillance Unit is available for consultation in relation to the Code's disclosure requirements on +44 (0)20 7638 0129.The Code can be viewed on the Panel's website atwww.thetakeoverpanel.org.uk

SUPPLEMENTAL FORM 8 (OPEN POSITIONS)

DETAILS OF OPEN STOCK-SETTLED DERIVATIVE (INCLUDING OPTION) POSITIONS, AGREEMENTS TO PURCHASE OR SELL ETC.

Note 5(i) on Rule 8 of the Takeover Code (the 'Code')

1. KEY INFORMATION

Full name of person making disclosure:

SOCIETE GENERALE SA

Name of offeror/offeree in relation to whose relevant securities the disclosure relates:

Shire Plc

2. STOCK-SETTLED DERIVATIVES (INCLUDING OPTIONS)

-

Class of relevant security

Product description e.g. call option

Written or purchased

Number of securities to which option or derivative relates

Exercise price per unit GBP

Type

Expiry date

e.g. American, European etc.

Ordinary

Listed call-option

Sale

150,000

32

American options

21/12/2018

Ordinary

Listed call-option

Purchase

30,000

40

American options

17/08/2018

Ordinary

Listed call-option

Purchase

75,000

41

American options

17/08/2018

Ordinary

Listed put-option

Sale

150,000

32

American options

21/12/2018

Class of relevant security

Product description e.g. call option

Written or purchased

Number of securities to which option or derivative relates

Exercise price per unit USD

Type

Expiry date

ADR

Listed put-option

Sale

20,000

155

American options

18/01/2019

3. AGREEMENTS TO PURCHASE OR SELL ETC.

Full details should be given so that the nature of the interest or position can be fully understood:

It is not necessary to provide details on a Supplemental Form (Open Positions) with regard to cash-settled derivatives.

The currency of all prices and other monetary amounts should be stated.

The Panel's Market Surveillance Unit is available for consultation in relation to the Code's disclosure requirements on +44 (0)20 7638 0129.

The Code can be viewed on the Panel's website atwww.thetakeoverpanel.org.uk.

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Shire plc published this content on 20 July 2018 and is solely responsible for the information contained herein. Distributed by Public, unedited and unaltered, on 20 July 2018 10:27:03 UTC