AMENDMENT Section 2(a)

FORM 8.5 (EPT/RI)

PUBLIC DEALING DISCLOSURE BY AN EXEMPT PRINCIPAL TRADER WITH RECOGNISED INTERMEDIARY STATUS DEALING IN A CLIENT-SERVING CAPACITY

Rule 8.5 of the Takeover Code (the 'Code')

1. KEY INFORMATION

(a) Name of exempt principal trader:

Morgan Stanley & Co. International plc

(b) Name of offeror/offeree in relation to whose relevant securities this form relates:

Use a separate form for each offeror/offeree

Shire plc

(c) Name of the party to the offer with which exempt principal trader is connected:

Shire plc

(d) Date dealing undertaken:

16 JULY 2018

(e)Has the EPT previously disclosed, or is it today disclosing, under the Code in respect of any other party to this offer?

Yes - Takeda Pharmaceutical Company Limited

2. DEALINGS BY THE EXEMPT PRINCIPAL TRADER

Where there have been dealings in more than one class of relevant securities of the offeror or offeree named in 1(b), copy table 2(a), (b), (c) or (d) (as appropriate) for each additional class of relevant security dealt in.

The currency of all prices and other monetary amounts should be stated.

(a) Purchases and sales

Class of relevant security

Purchases/sales

Total number of securities

Highest price per unit paid/received

Lowest price per unit paid/received

ADR

PURCHASES

390

172.2829 USD

172.2000 USD

ADR

SALES

390

172.2829 USD

172.2000 USD

5p ordinary

PURCHASES

283,369

43.6800 GBP

43.1200 GBP

5p ordinary

SALES

248,181

43.6700 GBP

43.1600 GBP

5p ordinary

PURCHASES

25,087

57.5049 USD

57.2915 USD

(b) Cash-settled derivative transactions

Class of relevant security

Product description

e.g. CFD

Nature of dealing

e.g. opening/closing a long/short position, increasing/reducing a long/short position

Number of reference securities

Price per unit

ADR

CFD

LONG

1,246

172.0600 USD

ADR

CFD

LONG

1,247

172.0600 USD

ADR

CFD

LONG

148

172.0600 USD

ADR

CFD

LONG

148

172.0600 USD

ADR

CFD

LONG

127

172.0600 USD

ADR

CFD

LONG

128

172.0600 USD

ADR

CFD

SHORT

124

172.2000 USD

ADR

CFD

SHORT

124

172.2000 USD

ADR

CFD

SHORT

148

172.2000 USD

ADR

CFD

SHORT

148

172.2000 USD

ADR

CFD

SHORT

27

172.2000 USD

ADR

CFD

SHORT

27

172.2000 USD

5p ordinary

CFD

LONG

30

43.2170 GBP

5p ordinary

CFD

LONG

2,193

43.2356 GBP

5p ordinary

CFD

LONG

4,940

43.2890 GBP

5p ordinary

CFD

LONG

12

43.2890 GBP

5p ordinary

CFD

LONG

13,600

43.3339 GBP

5p ordinary

CFD

LONG

5,000

43.3339 GBP

5p ordinary

CFD

LONG

749

43.3401 GBP

5p ordinary

CFD

LONG

250

43.3401 GBP

5p ordinary

CFD

LONG

92

43.3449 GBP

5p ordinary

CFD

LONG

185,452

43.4000 GBP

5p ordinary

CFD

LONG

540,830

43.4600 GBP

5p ordinary

CFD

LONG

7,007

43.4602 GBP

5p ordinary

CFD

SHORT

71

43.2027 GBP

5p ordinary

CFD

SHORT

71

43.2227 GBP

5p ordinary

CFD

SHORT

3,477

43.2397 GBP

5p ordinary

CFD

SHORT

1,475

43.2397 GBP

5p ordinary

CFD

SHORT

3,118

43.2400 GBP

5p ordinary

CFD

SHORT

3,118

43.2400 GBP

5p ordinary

CFD

SHORT

3

43.2400 GBP

5p ordinary

CFD

SHORT

8,470

43.2541 GBP

5p ordinary

CFD

SHORT

2,500

43.2618 GBP

5p ordinary

CFD

SHORT

646

43.2761 GBP

5p ordinary

CFD

SHORT

749

43.2761 GBP

5p ordinary

CFD

SHORT

700

43.2977 GBP

5p ordinary

CFD

SHORT

35,960

43.2977 GBP

5p ordinary

CFD

SHORT

540,830

43.4600 GBP

5p ordinary

CFD

SHORT

32

43.5643 GBP

5p ordinary

CFD

SHORT

59

43.5857 GBP

5p ordinary

CFD

SHORT

2

43.5857 GBP

5p ordinary

CFD

SHORT

32

43.5990 GBP

5p ordinary

CFD

LONG

8,570

43.6197 GBP

5p ordinary

CFD

LONG

8,491

43.6197 GBP

5p ordinary

CFD

LONG

79

43.6197 GBP

5p ordinary

CFD

SHORT

955

43.2648 GBP

5p ordinary

CFD

SHORT

17,140

43.6197 GBP

5p ordinary

CFD

SHORT

3,271

57.2916 USD

(c) Stock-settled derivative transactions (including options)

(i) Writing, selling, purchasing or varying

Class of relevant security

Product description e.g. call option

Writing, purchasing, selling, varying etc.

Number of securities to which option relates

Exercise price per unit

Typee.g. American, European etc.

Expiry date

Option money paid/ received per unit

N/A

N/A

N/A

N/A

N/A

N/A

N/A

N/A

(ii) Exercise

Class of relevant security

Product descriptione.g. call option

Number of securities

Exercise price per unit

N/A

N/A

N/A

N/A

(d) Other dealings (including subscribing for new securities)

Class of relevant security

Nature of dealinge.g. subscription, conversion

Details

Price per unit (if applicable)

N/A

N/A

N/A

N/A

The currency of all prices and other monetary amounts should be stated.

Where there have been dealings in more than one class of relevant securities of the offeror or offeree named in 1(b), copy table 2(a), (b), (c) or (d) (as appropriate) for each additional class of relevant security dealt in.

3. OTHER INFORMATION

(a) Indemnity and other dealing arrangements

Details of any indemnity or option arrangement, or any agreement or understanding, formal or informal, relating to relevant securities which may be an inducement to deal or refrain from dealing entered into by the exempt principal trader making the disclosure and any party to the offer or any person acting in concert with a party to the offer:

If there are no such agreements, arrangements or understandings, state 'none'

None

(b) Agreements, arrangements or understandings relating to options or derivatives

Details of any agreement, arrangement or understanding, formal or informal, between the exempt principal trader making the disclosure and any other person relating to:

(i) the voting rights of any relevant securities under any option; or

(ii) the voting rights or future acquisition or disposal of any relevant securities to which any derivative is referenced:

If there are no such agreements, arrangements or understandings, state 'none'

None

Date of disclosure:

18 JULY 2018

Contact name:

Craig Horsley

Telephone number:

+44(141) 245 7736

Public disclosures under Rule 8 of the Code must be made to a Regulatory Information Service and must also be emailed to the Takeover Panel atmonitoring@disclosure.org.uk. The Panel's Market Surveillance Unit is available for consultation in relation to the Code's dealing disclosure requirements on +44 (0)20 7638 0129.

The Code can be viewed on the Panel's website atwww.thetakeoverpanel.org.uk.

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