FORM 8.5 (EPT/RI)

PUBLIC DEALING DISCLOSURE BY AN EXEMPT PRINCIPAL TRADER WITH RECOGNISED INTERMEDIARY STATUS DEALING IN A CLIENT-SERVING CAPACITY

Rule 8.5 of the Takeover Code (the 'Code')

1. KEY INFORMATION

(a) Name of exempt principal trader:

J.P. Morgan Securities Plc

(b) Name of offeror/offeree in relation to whose relevant securities this form relates:

Use a separate form for each offeror/offeree

Shire plc

(c) Name of the party to the offer with which exempt principal trader is connected:

Joint Financial Adviser to Takeda Pharmaceutical Company Limited

(d) Date dealing undertaken:

13 July 2018

(e) In addition to the company in 1(b) above, is the exempt principal trader making disclosures in respect of any other party to this offer?

If it is a cash offer or possible cash offer, state 'N/A'

Yes, Takeda Pharmaceutical Company Limited

2. DEALINGS BY THE EXEMPT PRINCIPAL TRADER

Where there have been dealings in more than one class of relevant securities of the offeror or offeree named in 1(b), copy table 2(a), (b), (c) or (d) (as appropriate) for each additional class of relevant security dealt in.

The currency of all prices and other monetary amounts should be stated.

(a) Purchases and sales

Class of relevant security

Purchases/ sales

Total number of securities

Highest price per unit paid/received

(GBP)

Lowest price per unit paid/received

(GBP)

Ordinary Shares

Purchases

Sales

290,030

97,720

43.7400

43.7650

43.3062

43.3800

(b) Cash-settled derivative transactions

Class of relevant security

Product description

e.g. CFD

Nature of dealing

e.g. opening/closing a long/short position, increasing/reducing a long/short position

Number of reference securities

Price per unit

Ordinary Shares

Equity Swaps

Long

Short

4,069

976

88

38

1,514

1,293

483

1,266

2,170

185

18,339

559

5,318

1,840

2,830

20

628

2,042

1,509

404

7,991

13,595

17,293

2,471

8,164

1,521

604

4,577

1,304

1,598

2,943

4,747

3,226

1,184

87,311

100,000

43.3982 GBP

43.4000 GBP

43.4937 GBP

43.4998 GBP

43.5143 GBP

43.5225 GBP

43.5252 GBP

43.5257 GBP

43.5340 GBP

43.5737 GBP

43.6201 GBP

43.6343 GBP

43.6356 GBP

43.6472 GBP

43.7052 GBP

43.4000 GBP

43.4020 GBP

43.4035 GBP

43.5073 GBP

43.5151 GBP

43.5710 GBP

43.6258 GBP

43.6395 GBP

43.6439 GBP

43.6496 GBP

43.6595 GBP

43.6620 GBP

43.6643 GBP

43.6700 GBP

43.6802 GBP

43.6816 GBP

43.6821 GBP

43.6886 GBP

43.7132 GBP

57.2659 USD

57.4146 USD

(c) Stock-settled derivative transactions (including options)

(i) Writing, selling, purchasing or varying

Class of relevant security

Product description e.g. call option

Writing, purchasing, selling, varying etc.

Number of securities to which option relates

Exercise price per unit

(GBP)

Type

e.g. American, European etc.

Expiry date

Option money paid/ received per unit

(GBP)

(ii) Exercise

Class of relevant security

Product description

e.g. call option

Exercising/ exercised against

Number of securities

Exercise price per unit

(GBP)

(d) Other dealings (including subscribing for new securities)

Class of relevant security

Nature of dealing

e.g. subscription, conversion

Details

Price per unit (if applicable) (GBP)

3. OTHER INFORMATION

(a) Indemnity and other dealing arrangements

Details of any indemnity or option arrangement, or any agreement or understanding, formal or informal, relating to relevant securities which may be an inducement to deal or refrain from dealing entered into by the exempt principal trader making the disclosure and any party to the offer or any person acting in concert with a party to the offer:

Irrevocable commitments and letters of intent should not be included. If there are no such agreements, arrangements or understandings, state 'none'

None

(b) Agreements, arrangements or understandings relating to options or derivatives

Details of any agreement, arrangement or understanding, formal or informal, between the exempt principal trader making the disclosure and any other person relating to:

(i) the voting rights of any relevant securities under any option; or

(ii) the voting rights or future acquisition or disposal of any relevant securities to which any derivative is referenced:

If there are no such agreements, arrangements or understandings, state 'none'

None

Date of disclosure:

16 July 2018

Contact name:

Alwyn Basch

Telephone number:

020 7742 7407

Public disclosures under Rule 8 of the Code must be made to a Regulatory Information Service. The Panel's Market Surveillance Unit is available for consultation in relation to the Code's dealing disclosure requirements on +44 (0)20 7638 0129.

The Code can be viewed on the Panel's website atwww.thetakeoverpanel.org.uk.

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Shire plc published this content on 16 July 2018 and is solely responsible for the information contained herein. Distributed by Public, unedited and unaltered, on 16 July 2018 09:05:03 UTC