3(a) Shares held by Takeda directors and their close relatives and related trusts (excluding options and awards set out below):

Name of Takeda director

Number of Takeda shares

Percentage of issued share capital (%)

Christophe Weber

81,700

0.01

Masato Iwasaki

8,996

<0.01>

James Kehoe

3,900

<0.01>

Yoshiaki Fujimori

1,300

<0.01>

Masahiro Sakane

900

<0.01>

Toshiyuki Shiga

700

<0.01>

Yasuhiko Yamanaka

17,800

<0.01>

Shiro Kuniya

1,700

<0.01>

Koji Hatsukawa

600

<0.01>

Total

117,596

0.02

3(b) Shares allotted to Takeda directors under the BIP1

Name

Number of shares

Vesting date

Christophe Weber

122,184

1 June 2018; 1 June 2019 and 1 June 2020

Masato Iwasaki

7,333

1 June 2018; 1 June 2019 and 1 June 2020

Yoshiaki Fujimori

1,752

On retirement

Emiko Higashi

4,171

On retirement

Michel Orsinger

4,171

On retirement

Masahiro Sakane

1,752

On retirement

Toshiyuki Shiga

1,752

On retirement

Yasuhiko Yamanaka

4,908

On retirement

Shiro Kuniya

1,752

On retirement

Jean-Luc Butel

4,171

On retirement

Koji Hatsukawa

1,752

On retirement

1Board Incentive Plan ('BIP')

Directors may also receive shares under the BIP. Under this plan, Takeda shares are acquired under a trust and are granted to directors based on their achievement of certain performance indicators. Shares allotted to the external directors (being Yoshiaki Fuijmori, Emiko Higashi, Michel Orsinger, Masahiro Sakane and Toshiyuki Shiga) and directors who are Audit and Supervisory Committee members (being Yasuhiko Yamanaka, Shiro Kuniya, Jean-Luc Butel and Koji Hatsukawa, of whom all but Yasuhiko Yamanaka are also external directors) under the BIP are held on trust until the retirement of those directors. Shares allotted to non-Japan resident directors are sold in the market and those directors receive cash in lieu of shares. As shares are automatically allocated as part of a share compensation programme, there is no exercise price or expiry date.

3(c) Shares allotted to Takeda directors under the ESOP2

Name

Number of shares

Vesting date

Andrew S. Plump

44,248

1 June 2018; 1 June 2019 and 1 June 2020

2Employee Stock Ownership Plan ('ESOP')

As a senior employee of Takeda's US subsidiary, Andrew S. Plump is eligible for the ESOP. Under the ESOP, Takeda shares are granted to employees based on position and achievement of certain performance indicators (among other criteria). Beneficiaries may opt to convert shares to be allotted to them into cash under the provisions of the trust agreement. Vesting is generally conditional on continued service from the date of grant to the date of vesting. Shares allotted to non-Japan resident beneficiaries are sold in the market and those directors receive cash in lieu of shares. As shares are automatically allocated as part of a share compensation programme, there is no exercise price or expiry date.

3(d) Options owned by Takeda directors (issued 2010 - 2013)

Takeda issued stock options ('Stock Acquisition Rights') to its directors and senior employees until 2013, when this program was replaced by the BIP / ESOP programs referred to elsewhere on this form. It is a condition of execution of all Stock Acquisition Rights that the person exercising that Right is a director of Takeda at the time the right is exercised, unless that director: (i) has resigned; (ii) has retired due to expiration of term of office; or (iii) there is any other valid reason.

Stock Acquisition Rights issued 25 June 2010

Name of Director

Payment value (¥)

Financial value to be invested upon execution (¥)

Exercise period

Type and number of shares subject to Stock Acquisition Right

Number of Stock Acquisition Rights

Yasuhiko Yamanaka

3,028 per share

1 per share

11 July 2013 to 10 July 2020

7,000 ordinary shares

70

Stock Acquisition Rights issued 24 June 2011 (Series 1)

Name of Director

Payment value (¥)

Financial value to be invested upon execution (¥)

Exercise period

Type and number of shares subject to Stock Acquisition Right

Number of Stock Acquisition Rights

Yasuhiko Yamanaka

2,726 per share

1 per share

16 July 2014 to 15 July 2021

10,100 ordinary shares

101

Stock Acquisition Rights issued 24 June 2011 (Series 2)

Name of Director

Payment value (¥)

Financial value to be invested upon execution (¥)

Exercise period

Type and number of shares subject to Stock Acquisition Right

Number of Stock Acquisition Rights

Masato Iwasaki

427 per share

3,705 per share

16 July 2014 to 15 July 2031

42,900 ordinary shares

429

Stock Acquisition Rights issued 26 June 2012 (Series 1)

Name of Director

Payment value (¥)

Financial value to be invested upon execution (¥)

Exercise period

Type and number of shares subject to Stock Acquisition Right

Number of Stock Acquisition Rights

Masato Iwasaki

2,678 per share

1 per share

18 July 2015 to 17 July 2022

7,900

79

Yasuhiko Yamanaka

2,678 per share

1 per share

18 July 2015 to 17 July 2022

10,700

107

Stock Acquisition Rights issued 26 June 2013 (Series 1)

Name of Director

Payment value (¥)

Financial value to be invested upon execution (¥)

Exercise period

Type and number of shares subject to Stock Acquisition Right

Number of Stock Acquisition Rights

Masato Iwasaki

3,709 per share

1 per share

20 July 2016 to 19 July 2023

6,100

61

Yasuhiko Yamanaka

3,709 per share

1 per share

20 July 2016 to 19 July 2023

8,200

82

3(e) Interests of other persons acting in concert with Takeda:

Name of concert party

Number of Takeda shares

Watanabe Chemical Co Ltd3

12,000

Amato Pharmaceutical Products Ltd3

275,000

Total

287,000

3Because Takeda owns or controls 25% or more of the voting rights in these parties, under Japan's Companies Act, the parties' shareholdings do not carry any rights to vote. These shares are therefore excluded from the calculation of the total number of shares in issue.

3(f) Interests held by connected advisers of Takeda:

Name of adviser

Interests held

J.P. Morgan Cazenove

By J.P. Morgan Securities LLC (PCS): 59 (Equity Depository Receipt (Long)) (other than Rule 8 exempt entities)

By JPMorgan Structured Products BV: 6,121 (Physically-settled derivatives (Long)) (other than Rule 8 exempt entities)

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Shire plc published this content on 23 July 2018 and is solely responsible for the information contained herein. Distributed by Public, unedited and unaltered, on 23 July 2018 15:17:06 UTC