BLOCK LISTING SIX MONTHLY RETURN

November 24, 2014 - Shire plc (LSE: SHP, NASDAQ: SHPG)

Name of applicant:                     Shire plc

Name of scheme:                        2000 Executive Share Option Scheme

Period of return:            From:     May 23, 2014      To:  November 22, 2014

Balance of unallotted securities under 3,406,623
scheme(s) from previous return:

Plus: The amount by which the block    Nil
scheme(s) has been increased since the
date of the last return (if any
increase has been applied for):

Less: Number of securities issued/     Nil
allotted under scheme(s) during period
(see LR3.5.7G):

Equals: Balance under scheme(s) not    3,406,623
yet issued/allotted at end of period:

Name of applicant:                     Shire plc

Name of scheme:                        Shire Sharesave Scheme

Period of return:            From:     May 23, 2014      To:  November 22, 2014

Balance of unallotted securities under 210,392
scheme(s) from previous return:

Plus: The amount by which the block    Nil
scheme(s) has been increased since the
date of the last return (if any
increase has been applied for):

Less: Number of securities issued/     2,634
allotted under scheme(s) during period
(see LR3.5.7G):

Equals: Balance under scheme(s) not    207,758
yet issued/allotted at end of period:

Name of applicant:                     Shire plc

Name of scheme:                        Portfolio Share Plan

Period of return:            From:     May 23, 2014      To:  November 22, 2014

Balance of unallotted securities under 1,594,259
scheme(s) from previous return:

Plus: The amount by which the block    Nil
scheme(s) has been increased since the
date of the last return (if any
increase has been applied for):

Less: Number of securities issued/     456,045
allotted under scheme(s) during period
(see LR3.5.7G):

Equals: Balance under scheme(s) not    1,138,214
yet issued/allotted at end of period:

Name of applicant:                     Shire plc

Name of scheme:                        Employee Stock Purchase Plan

Period of return:            From:     May 23, 2014      To:  November 22, 2014

Balance of unallotted securities under 422,301
scheme(s) from previous return:

Plus: The amount by which the block    500,000
scheme(s) has been increased since the
date of the last return (if any
increase has been applied for):

Less: Number of securities issued/     397,591
allotted under scheme(s) during period
(see LR3.5.7G):

Equals: Balance under scheme(s) not    524,710
yet issued/allotted at end of period:

Name of contact:                        Tony Guthrie, Deputy Company Secretary

Address of contact:                     Hampshire International Business Park

                                        Basingstoke, Hampshire, RG24 8EP

Telephone number of contact:            01256 894746

For further information please contact:

Investor Relations

Jeff Poulton                            jpoulton@shire.com   +1 781 482 0945

Sarah Elton-Farr                        seltonfarr@shire.com +44 1256 894157

NOTES TO EDITORS

Shire enables people with life-altering conditions to lead better lives.

Our strategy is to focus on developing and marketing innovative specialty
medicines to meet significant unmet patient needs.

We focus on providing treatments in Neuroscience, Rare Diseases,
Gastrointestinal, and Internal Medicine and we are developing treatments for
symptomatic conditions treated by specialist physicians in other targeted
therapeutic areas, such as Ophthalmology.

www.shire.com

Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX

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www.shire.com