BLOCK LISTING SIX MONTHLY RETURN

    November 23, 2015 - Shire plc (LSE: SHP, NASDAQ: SHPG)

    Name of applicant:                          Shire plc                                  
                                                                                           
    Name of scheme:                             Shire Sharesave Scheme                     
                                                                                           
    Period of return:                From:      May 23, 2015       To:   November 22, 2015 
                                                                                           
    Balance of unallotted securities under      203,551                                    
    scheme(s) from previous return:                                                        
                                                                                           
    Plus:  The amount by which the block scheme Nil                                        
    (s) has been increased since the date of                                               
    the last return (if any increase has been                                              
    applied for):                                                                          
                                                                                           
    Less:  Number of securities issued/allotted 1,635                                      
    under scheme(s) during period (see                                                     
    LR3.5.7G):                                                                             
                                                                                           
    Equals:  Balance under scheme(s) not yet    201,916                                    
    issued/allotted at end of period:                                                      
                                                                                           

       

    Name of applicant:                          Shire plc                                  
                                                                                           
    Name of scheme:                             Shire Portfolio Share Plan                 
                                                                                           
    Period of return:                From:      May 23, 2015       To:  November 22, 2015  
                                                                                           
    Balance of unallotted securities under      1,785,069                                  
    scheme(s) from previous return:                                                        
                                                                                           
    Plus:  The amount by which the block scheme Nil                                        
    (s) has been increased since the date of                                               
    the last return (if any increase has been                                              
    applied for):                                                                          
                                                                                           
    Less:  Number of securities issued/allotted 264,963                                    
    under scheme(s) during period (see                                                     
    LR3.5.7G):                                                                             
                                                                                           
    Equals:  Balance under scheme(s) not yet    1,520,106                                  
    issued/allotted at end of period:                                                      
                                                                                           

       

    Name of applicant:                          Shire plc                                  
                                                                                           
    Name of scheme:                             Shire Employee Stock Purchase Plan         
                                                                                           
    Period of return:                From:      May 23, 2015       To:  November 22, 2015  
                                                                                           
    Balance of unallotted securities under      522,337                                    
    scheme(s) from previous return:                                                        
                                                                                           
    Plus:  The amount by which the block scheme Nil                                        
    (s) has been increased since the date of                                               
    the last return (if any increase has been                                              
    applied for):                                                                          
                                                                                           
    Less:  Number of securities issued/allotted 273,110                                    
    under scheme(s) during period (see                                                     
    LR3.5.7G):                                                                             
                                                                                           
    Equals:  Balance under scheme(s) not yet    249,227                                    
    issued/allotted at end of period:                                                      
                                                                                           

       

    Name of applicant:                          Shire plc                                  
                                                                                           
    Name of scheme:                             Shire Long Term Incentive Plan 2015        
                                                                                           
    Period of return:                From:      May 23, 2015       To:  November 22, 2015  
                                                                                           
    Balance of unallotted securities under      3,000,000                                  
    scheme(s) from previous return:                                                        
                                                                                           
    Plus:  The amount by which the block scheme Nil                                        
    (s) has been increased since the date of                                               
    the last return (if any increase has been                                              
    applied for):                                                                          
                                                                                           
    Less:  Number of securities issued/allotted 8,760                                      
    under scheme(s) during period (see                                                     
    LR3.5.7G):                                                                             
                                                                                           
    Equals:  Balance under scheme(s) not yet    2,991,240                                  
    issued/allotted at end of period:                                                      
                                                                                           

       

    Name of applicant:                          Shire plc                                  
                                                                                           
    Name of scheme:                             Shire Global Employee Stock Purchase Plan  
                                                                                           
    Period of return:                From:      November 2, 2015   To:  November 22, 2015  
                                                                                           
    Balance of unallotted securities under      Nil                                        
    scheme(s) from previous return:                                                        
                                                                                           
    Plus:  The amount by which the block scheme 2,000,000                                  
    (s) has been increased since the date of                                               
    the last return (if any increase has been                                              
    applied for):                                                                          
                                                                                           
    Less:  Number of securities issued/allotted Nil                                        
    under scheme(s) during period (see                                                     
    LR3.5.7G):                                                                             
                                                                                           
    Equals:  Balance under scheme(s) not yet    2,000,000                                  
    issued/allotted at end of period:                                                      
                                                                                           

       

    Name of contact:                           Oliver Strawbridge, Senior Assistant Company
                                               Secretary                                   
                                                                                           
    Telephone number of contact:               01256 894000                                

    For further information please contact:

    Investor Relations                                                           
                                                                                 
    Matthew Osborne                     mattosborne@shire.com  +1 781 482 9502   
                                                                                 
    Sarah Elton-Farr                    seltonfarr@shire.com   +44 1256 894157   

    NOTES TO EDITORS

    Shire enables people with life-altering conditions to lead better lives.

    Our strategy is to focus on developing and marketing innovative specialty
    medicines to meet significant unmet patient needs.

    We focus on providing treatments in Rare Diseases, Neuroscience,
    Gastrointestinal and Internal Medicine and we are developing treatments for
    symptomatic conditions treated by specialist physicians in other targeted
    therapeutic areas, such as Ophthalmics.

    www.shire.com