Director Declaration

    July 29, 2015 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company") announces
    that its Chairman, Susan Kilsby, was appointed to the Board of Fortune Brands
    Home & Security, Inc. on July 28, 2015.

    This notification is to satisfy the Company's obligations under 9.6.14R of the
    UK Listing Rules.

    Tony Guthrie
    Deputy Company Secretary

    For further information please contact:

    Investor Relations                                                           
                                                                                 
    Sarah Elton-Farr                      seltonfarr@shire.com +44 1256 894157   

    NOTES TO EDITORS

    Shire enables people with life-altering conditions to lead better lives.

    Our strategy is to focus on developing and marketing innovative specialty
    medicines to meet significant unmet patient needs.

    We focus on providing treatments in Rare Diseases, Neuroscience,
    Gastrointestinal and Internal Medicine and we are developing treatments for
    symptomatic conditions treated by specialist physicians in other targeted
    therapeutic areas, such as Ophthalmics.

    http://www.shire.com/