Director/PDMR Share Dealings

October 27, 2014 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company") announces
it was notified today that Susan Kilsby, Chairman of the Company, acquired
2,500 American Depositary Shares ("ADSs") on October 24, 2014 at an average
price of US$194.4264 per ADS.

Following the above transaction, Ms Kilsby holds 3,041 ADSs. One ADS is equal
to three ordinary shares of 5 pence each in the Company.

This notification is to satisfy the Company's obligations under 3.1.4(R)(1)(a)
of the Disclosure and Transparency Rules.

Tony Guthrie
Deputy Company Secretary

For further information please contact:

Investor Relations
Jeff Poulton                            jpoulton@shire.com   +1 781 482 0945
Sarah Elton-Farr                        seltonfarr@shire.com +44 1256 894157


NOTES TO EDITORS

Shire enables people with life-altering conditions to lead better lives.

Our strategy is to focus on developing and marketing innovative specialty
medicines to meet significant unmet patient needs.

We focus on providing treatments in Neuroscience, Rare Diseases,
Gastrointestinal, and Internal Medicine and we are developing treatments for
symptomatic conditions treated by specialist physicians in other targeted
therapeutic areas, such as Ophthalmology.

www.shire.com


Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX

Press Release

www.shire.com