Elections for Interim Dividend in Respect of the Six Months to June 30, 2015

    August 24, 2015 - Shire plc (LSE: SHP, NASDAQ: SHPG) announced on July 23,
    2015, an interim dividend of 4.21 US cents per Ordinary Share payable on
    October 2, 2015, to shareholders on the register of members at the close of
    business on September 4, 2015.

    Shareholders are reminded that the final date for submission of elections to
    receive UK sourced dividends via the income access share arrangements is
    September 4, 2015. In the absence of any such elections, previous elections or
    deemed elections will remain in force.

    Shareholders who do not elect (or have not been deemed to elect) to receive UK
    sourced dividends through the income access share arrangements are reminded
    that their dividends will be Irish sourced and subject to Irish dividend
    withholding tax unless the Company's Registrar is in possession of a valid
    exemption form by 5pm on September 4, 2015.

    Enquiries may be addressed to the Company's Registrar's helpline on 0871 384
    2553 or +44 121 415 7593.

    Tony Guthrie
    Deputy Company Secretary

    For further information please contact:

    Investor Relations                                                           
                                                                                 
    Sarah Elton-Farr                      seltonfarr@shire.com +44 1256 894157   

    NOTES TO EDITORS

    Shire enables people with life-altering conditions to lead better lives.

    Our strategy is to focus on developing and marketing innovative specialty
    medicines to meet significant unmet patient needs.

    We focus on providing treatments in Rare Diseases, Neuroscience,
    Gastrointestinal and Internal Medicine and we are developing treatments for
    symptomatic conditions treated by specialist physicians in other targeted
    therapeutic areas, such as Ophthalmics.

    http://www.shire.com/