Total Voting Rights

    October 1, 2015 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company"), in
    accordance with the Financial Conduct Authority's (the "FCA") Disclosure and
    Transparency Rule 5.6.1R, notifies the market of the following:

    As at September 30, 2015, the Company's issued ordinary share capital comprised
    592,061,538 ordinary shares of 5 pence each with voting rights and a further
    8,527,703 ordinary shares held in treasury.

    Therefore the total number of voting rights in the Company is 592,061,538. This
    is the figure which should be used by shareholders as the denominator for the
    calculations by which they will determine if they are required to notify their
    interest in, or a change to their interest in, the Company under the FCA's
    Disclosure and Transparency Rules.

    Oliver Strawbridge
    Senior Assistant Company Secretary

    For further information please contact:

    Investor Relations                                                            
                                                                                  
    Matthew Osborne                       mattosborne@shire.com +1 781 482 9502   
                                                                                  
    Sarah Elton-Farr                      seltonfarr@shire.com  +44 1256 894157   

    NOTES TO EDITORS

    Shire enables people with life-altering conditions to lead better lives.

    Our strategy is to focus on developing and marketing innovative specialty
    medicines to meet significant unmet patient needs.

    We focus on providing treatments in Rare Diseases, Neuroscience,
    Gastrointestinal and Internal Medicine and we are developing treatments for
    symptomatic conditions treated by specialist physicians in other targeted
    therapeutic areas, such as Ophthalmics.

    http://www.shire.com/