Holding(s) in Company - Amendment

    June 22, 2015 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company")

    As a result of erroneous information received by the Company relating to
    interests in its securities, specifically the number of shares/voting rights
    disposed of, this announcement replaces the original announcement released on
    June 18, 2015, at 16:38.

    1. Identity of the issuer or the underlying issuer of         Shire plc   
    existing shares to which voting rights are attached:                      
                                                                              
    2. Reason for the notification                                State       
                                                                  Yes/No      
                                                                              
    An acquisition or disposal of voting rights                   Yes         
                                                                              
    An acquisition or disposal of qualifying financial                        
    instruments which may result in the acquisition of shares     No          
    already issued to which voting rights are attached                        
                                                                              
    An acquisition or disposal of instruments with similar                    
    economic effect to qualifying financial instruments           No          
                                                                              
    An event changing the breakdown of voting rights              No          
                                                                              
    Other (please specify):                                       No          

       

    3. Full name of person(s) subject to the notification  FMR LLC           
    obligation:                                                              
                                                                             
    4. Full name of shareholder(s) (if different from 3.): See Section 9     
                                                                             
    5. Date of the transaction (and date on which the      June 17, 2015     
    threshold is crossed or reached if different):                           
                                                                             
    6. Date on which issuer notified:                      June 19, 2015     
                                                                             
    7. Threshold(s) that is/are crossed or reached:        5%                

       

    8. Notified details:                                                                 
                                                                                         
    A: Voting rights attached to shares                                                  
                                                                                         
                    Situation previous to Resulting situation after the triggering       
    Class/type of   the triggering        transaction                                    
    shares          transaction                                                          
     if possible                                                                         
    using the ISIN  Number     Number     Number      Number of voting   % of voting     
    CODE            of         of         of          rights             rights          
                    Shares     Voting     shares                                         
                               Rights                                                    
                                          Indirect    Direct Indirect    Direct Indirect 
                                                                                         
                    29,674,746 29,674,746 29,421,281         29,421,281           4.97   
    JE00B2QKY057                                                                         
                                                                                         

       

    B: Qualifying Financial Instruments                                             
                                                                                    
    Resulting situation after the triggering transaction                            
                                                                                    
    Type of       Expiration    Exercise/         Number of voting       % of voting
    financial     date          Conversion        rights that may be     rights     
    instrument                  Period/ Date      acquired if  the                  
                                                  instrument                        
                                                  is exercised/converted            
                                                                                    

       

    C: Financial Instruments with similar economic effect to Qualifying Financial    
    Instruments                                                                      
                                                                                     
    Resulting situation after the triggering transaction                             
                                                                                     
    Type of        Exercise Expiration Exercise/    Number of voting % of voting     
    financial      price    date       Conversion   rights           rights          
    instrument                         period       instrument                       
                                                    refers to                        
                                                                                     
                                                                     Nominal   Delta 
                                                                                     

       

    Total (A+B+C)                                                                
                                                                                 
    Number of voting rights              % of voting rights                      
                                                                                 
    29,421,281                           4.97                                    

       

    9. Chain of controlled undertakings through which the voting rights and/or the         
    financial instruments are effectively held, if applicable:                             
                                                                                           
    Custodian                    Day to Day IM                                   Total     
                                                                                           
                                 CROSBY ADVS LLC-CROSBY ADVISORS LLC             25,723    
                                                                                           
    BANK OF NEW YORK MELLON      PGALLC-PYRAMIS GLOBAL ADVISORS, LLC             347,644   
                                                                                           
    BROWN BROS HARRIMN LTD LUX   FMRC-FMR CO., INC                               3,900     
    (C)                                                                                    
                                                                                           
    BROWN BROTHERS HARRIMAN AND  FMRC-FMR CO., INC                               7,203,490 
    CO                                                                                     
                                                                                           
                                 FMRIMUK-FMR INVESTMENT MANAGEMENT (UK) LIMITED  57,900    
                                                                                           
                                 PGALLC-PYRAMIS GLOBAL ADVISORS, LLC             28,719    
                                                                                           
                                 PYRAMIS GLOBAL-PYRAMIS GLOBAL ADVISORS TRUST    721,869   
                                 COMPANY                                                   
                                                                                           
    CIBC MELLON TRUST (C)        PGALLC-PYRAMIS GLOBAL ADVISORS, LLC             22,525    
                                                                                           
                                 PYRAMIS GLOBAL-PYRAMIS GLOBAL ADVISORS TRUST    17,700    
                                 COMPANY                                                   
                                                                                           
    CITIBANK NA, HONG KONG BR    PGALLC-PYRAMIS GLOBAL ADVISORS, LLC             27,377    
    (S)                                                                                    
                                                                                           
    DEUTSCHE BANK ALEX BROWN (C) PGALLC-PYRAMIS GLOBAL ADVISORS, LLC             6,000     
                                                                                           
    JP MORGAN, BOURNEMOUTH (C)   PGALLC-PYRAMIS GLOBAL ADVISORS, LLC             16,574    
                                                                                           
                                 PYRAMIS GLOBAL-PYRAMIS GLOBAL ADVISORS TRUST    30,831    
                                 COMPANY                                                   
                                                                                           
    JPMORGAN CHASE BANK          FMRC-FMR CO., INC                               8,176,441 
                                                                                           
                                 FMRIMUK-FMR INVESTMENT MANAGEMENT (UK) LIMITED  482,300   
                                                                                           
                                 PYRAMIS GLOBAL-PYRAMIS GLOBAL ADVISORS TRUST    41,933    
                                 COMPANY                                                   
                                                                                           
    MELLON BANK NA (C)           PGALLC-PYRAMIS GLOBAL ADVISORS, LLC             77,068    
                                                                                           
    MORGAN STANLEY AND CO LLC    PGALLC-PYRAMIS GLOBAL ADVISORS, LLC             2,100     
                                                                                           
    NATIONAL BANK TRUST (C)      PYRAMIS GLOBAL-PYRAMIS GLOBAL ADVISORS TRUST    25,225    
                                 COMPANY                                                   
                                                                                           
    NATIONAL FINANCIAL SERVICES  SAI-STRATEGIC ADVISERS, INC.                    1,346     
    (C)                                                                                    
                                                                                           
    NORTHERN TRUST CO (C)        FMRC-FMR CO., INC                               2,724,688 
                                                                                           
                                 FMRIMUK-FMR INVESTMENT MANAGEMENT (UK) LIMITED  1,669,700 
                                                                                           
                                 PGALLC-PYRAMIS GLOBAL ADVISORS, LLC             110,800   
                                                                                           
                                 PYRAMIS GLOBAL-PYRAMIS GLOBAL ADVISORS TRUST    44,001    
                                 COMPANY                                                   
                                                                                           
    STATE STR BK AND TR CO LNDN  PGALLC-PYRAMIS GLOBAL ADVISORS, LLC             34,898    
    (C                                                                                     
                                                                                           
    STATE STREET BANK AND TR CO  FMRC-FMR CO., INC                               6,247,251 
                                                                                           
                                 FMRIMUK-FMR INVESTMENT MANAGEMENT (UK) LIMITED  449,700   
                                                                                           
                                 PGALLC-PYRAMIS GLOBAL ADVISORS, LLC             430,756   
                                                                                           
                                 PYRAMIS GLOBAL-PYRAMIS GLOBAL ADVISORS TRUST    360,012   
                                 COMPANY                                                   
                                                                                           
    US BANK NA (C)               PGALLC-PYRAMIS GLOBAL ADVISORS, LLC             32,810    
                                                                                           
    Grand Total                                                                  29,421,281

       

    Proxy Voting:                                                                
                                                             FMR LLC             
    10. Name of the proxy holder:                                                
                                                                                 
    11. Number of voting rights proxy holder will cease to   253,465             
    hold:                                                                        
                                                                                 
    12. Date on which proxy holder will cease to hold voting June 17, 2015       
    rights:                                                                      

       

    13. Additional information:       None                                       
                                                                                 
    14. Contact name:                 Sally-Ann Hatton                           
                                                                                 
    15. Contact telephone number:                                                
                                      fil-regreporting@fil.com, 01737 837148     

    For further information please contact:

    Investor Relations                                                           
                                                                                 
    Sarah Elton-Farr                      seltonfarr@shire.com +44 1256 894157   

    NOTES TO EDITORS

    Shire enables people with life-altering conditions to lead better lives.

    Our strategy is to focus on developing and marketing innovative specialty
    medicines to meet significant unmet patient needs.

    We focus on providing treatments in Rare Diseases, Neuroscience,
    Gastrointestinal and Internal Medicine and we are developing treatments for
    symptomatic conditions treated by specialist physicians in other targeted
    therapeutic areas, such as Ophthalmics.

    http://www.shire.com/