Director/PDMR Shareholding

    September 30, 2016 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company")

    Notification of transactions by persons discharging managerial responsibilities

    1.   Details of the person discharging managerial responsibilities       
         ("PDMR") / person closely associated with them ("PCA")              
                                                                             
    a)   Name              Susan Kilsby                                      
                                                                             
    2.   Reason for the notification                                         
                                                                             
    a)   Position / status Chairman - PDMR                                   
                                                                             
    b)   Initial           Initial notification                              
         notification /                                                      
         amendment                                                           
                                                                             
    3.   Details of the issuer, emission allowance participant, auction      
         platform, auctioneer or auction monitor                             
                                                                             
    a)   Name              Shire plc                                         
                                                                             
    b)   LEI               54930005LQRLI2UXRQ59                              
                                                                             
    4.   Details of the transaction(s): section to be repeated for (i) each  
         type of instrument; (ii) each type of transaction; (iii) each date; 
         and (iv) each place where transactions have been conducted          
                                                                             
    a)   Description of    Shire plc American Depositary Shares ("ADSs")     
         the financial                                                       
         instrument, type                                                    
         of instrument                                                       
                                                                             
         Identification    ISIN: US82481R1068                                
         code                                                                
                                                                             
    b)   Nature of the     Acquisition of ADSs, being the part of Ms.        
         transaction       Kilsby's total fees that are paid in ADSs for the 
                           period of service from July 1 to September 30,    
                           2016.                                             
                                                                             
    c)   Price(s) and              Price(s)                 Volume(s)        
         volume(s)                                                           
                                   $194.99                     150           
                                                                             
    d)   Aggregated        N/A (single transaction)                          
         information                                                         
                                                                             
    e)   Date of the       September 30, 2016                                
         transaction                                                         
                                                                             
    f)   Place of the      NASDAQ Global Select Market                       
         transaction                                                         

       

    1.   Details of the person discharging managerial responsibilities       
         ("PDMR") / person closely associated with them ("PCA")              
                                                                             
    a)   Name              William Burns                                     
                                                                             
    2.   Reason for the notification                                         
                                                                             
    a)   Position / status Senior Independent Director - PDMR                
                                                                             
    b)   Initial           Initial notification                              
         notification /                                                      
         amendment                                                           
                                                                             
    3.   Details of the issuer, emission allowance participant, auction      
         platform, auctioneer or auction monitor                             
                                                                             
    a)   Name              Shire plc                                         
                                                                             
    b)   LEI               54930005LQRLI2UXRQ59                              
                                                                             
    4.   Details of the transaction(s): section to be repeated for (i) each  
         type of instrument; (ii) each type of transaction; (iii) each date; 
         and (iv) each place where transactions have been conducted          
                                                                             
    a)   Description of    Shire plc Ordinary Shares of 5 pence each         
         the financial     ("Ordinary Shares")                               
         instrument, type                                                    
         of instrument                                                       
                                                                             
         Identification    ISIN: JE00B2QKY057                                
         code                                                                
                                                                             
    b)   Nature of the     Acquisition of Ordinary Shares, being the part of 
         transaction       Mr. Burns' total fees that are paid in Ordinary   
                           Shares for the period of service from July 1 to   
                           September 30, 2016.                               
                                                                             
    c)   Price(s) and              Price(s)                 Volume(s)        
         volume(s)                                                           
                                    £50.10                     139           
                                                                             
    d)   Aggregated        N/A (single transaction)                          
         information                                                         
                                                                             
    e)   Date of the       September 30, 2016                                
         transaction                                                         
                                                                             
    f)   Place of the      London Stock Exchange (XLON)                      
         transaction                                                         

       

    1.   Details of the person discharging managerial responsibilities       
         ("PDMR") / person closely associated with them ("PCA")              
                                                                             
    a)   Name              Dominic Blakemore                                 
                                                                             
    2.   Reason for the notification                                         
                                                                             
    a)   Position / status Non-Executive Director - PDMR                     
                                                                             
    b)   Initial           Initial notification                              
         notification /                                                      
         amendment                                                           
                                                                             
    3.   Details of the issuer, emission allowance participant, auction      
         platform, auctioneer or auction monitor                             
                                                                             
    a)   Name              Shire plc                                         
                                                                             
    b)   LEI               54930005LQRLI2UXRQ59                              
                                                                             
    4.   Details of the transaction(s): section to be repeated for (i) each  
         type of instrument; (ii) each type of transaction; (iii) each date; 
         and (iv) each place where transactions have been conducted          
                                                                             
    a)   Description of    Shire plc Ordinary Shares of 5 pence each         
         the financial     ("Ordinary Shares")                               
         instrument, type                                                    
         of instrument                                                       
                                                                             
         Identification    ISIN: JE00B2QKY057                                
         code                                                                
                                                                             
    b)   Nature of the     Acquisition of Ordinary Shares, being the part of 
         transaction                           Mr. Blakemore's total fees    
                           that are paid in Ordinary Shares for the period of
                           service from July 1 to September 30, 2016.        
                                                                             
    c)   Price(s) and              Price(s)                 Volume(s)        
         volume(s)                                                           
                                    £50.10                     133           
                                                                             
    d)   Aggregated        N/A (single transaction)                          
         information                                                         
                                                                             
    e)   Date of the       September 30, 2016                                
         transaction                                                         
                                                                             
    f)   Place of the      London Stock Exchange (XLON)                      
         transaction                                                         

       

    1.   Details of the person discharging managerial responsibilities       
         ("PDMR") / person closely associated with them ("PCA")              
                                                                             
    a)   Name              Olivier Bohuon                                    
                                                                             
    2.   Reason for the notification                                         
                                                                             
    a)   Position / status Non-Executive Director - PDMR                     
                                                                             
    b)   Initial           Initial notification                              
         notification /                                                      
         amendment                                                           
                                                                             
    3.   Details of the issuer, emission allowance participant, auction      
         platform, auctioneer or auction monitor                             
                                                                             
    a)   Name              Shire plc                                         
                                                                             
    b)   LEI               54930005LQRLI2UXRQ59                              
                                                                             
    4.   Details of the transaction(s): section to be repeated for (i) each  
         type of instrument; (ii) each type of transaction; (iii) each date; 
         and (iv) each place where transactions have been conducted          
                                                                             
    a)   Description of    Shire plc Ordinary Shares of 5 pence each         
         the financial     ("Ordinary Shares")                               
         instrument, type                                                    
         of instrument                                                       
                                                                             
         Identification    ISIN: JE00B2QKY057                                
         code                                                                
                                                                             
    b)   Nature of the     Acquisition of Ordinary Shares, being the part of 
         transaction       Mr. Bohuon's total fees that are paid in Ordinary 
                           Shares for the period of service from July 1 to   
                           September 30, 2016.                               
                                                                             
    c)   Price(s) and              Price(s)                 Volume(s)        
         volume(s)                                                           
                                    £50.10                     131           
                                                                             
    d)   Aggregated        N/A (single transaction)                          
         information                                                         
                                                                             
    e)   Date of the       September 30, 2016                                
         transaction                                                         
                                                                             
    f)   Place of the      London Stock Exchange (XLON)                      
         transaction                                                         

       

    1.   Details of the person discharging managerial responsibilities       
         ("PDMR") / person closely associated with them ("PCA")              
                                                                             
    a)   Name              Gail Fosler                                       
                                                                             
    2.   Reason for the notification                                         
                                                                             
    a)   Position / status Non-Executive Director - PDMR                     
                                                                             
    b)   Initial           Initial notification                              
         notification /                                                      
         amendment                                                           
                                                                             
    3.   Details of the issuer, emission allowance participant, auction      
         platform, auctioneer or auction monitor                             
                                                                             
    a)   Name              Shire plc                                         
                                                                             
    b)   LEI               54930005LQRLI2UXRQ59                              
                                                                             
    4.   Details of the transaction(s): section to be repeated for (i) each  
         type of instrument; (ii) each type of transaction; (iii) each date; 
         and (iv) each place where transactions have been conducted          
                                                                             
    a)   Description of    Shire plc American Depositary Shares ("ADSs")     
         the financial                                                       
         instrument, type                                                    
         of instrument                                                       
                                                                             
         Identification    ISIN: US82481R1068                                
         code                                                                
                                                                             
    b)   Nature of the     Acquisition of ADSs, being the part of Ms.        
         transaction       Fosler's total fees that are paid in ADSs for the 
                           period of service from July 1 to September 30,    
                           2016.                                             
                                                                             
    c)   Price(s) and              Price(s)                 Volume(s)        
         volume(s)                                                           
                                   $194.99                     49            
                                                                             
    d)   Aggregated        N/A (single transaction)                          
         information                                                         
                                                                             
    e)   Date of the       September 30, 2016                                
         transaction                                                         
                                                                             
    f)   Place of the      NASDAQ Global Select Market                       
         transaction                                                         

       

    1.   Details of the person discharging managerial responsibilities       
         ("PDMR") / person closely associated with them ("PCA")              
                                                                             
    a)   Name              Steven Gillis                                     
                                                                             
    2.   Reason for the notification                                         
                                                                             
    a)   Position / status Non-Executive Director - PDMR                     
                                                                             
    b)   Initial           Initial notification                              
         notification /                                                      
         amendment                                                           
                                                                             
    3.   Details of the issuer, emission allowance participant, auction      
         platform, auctioneer or auction monitor                             
                                                                             
    a)   Name              Shire plc                                         
                                                                             
    b)   LEI               54930005LQRLI2UXRQ59                              
                                                                             
    4.   Details of the transaction(s): section to be repeated for (i) each  
         type of instrument; (ii) each type of transaction; (iii) each date; 
         and (iv) each place where transactions have been conducted          
                                                                             
    a)   Description of    Shire plc American Depositary Shares ("ADSs")     
         the financial                                                       
         instrument, type                                                    
         of instrument                                                       
                                                                             
         Identification    ISIN: US82481R1068                                
         code                                                                
                                                                             
    b)   Nature of the     Acquisition of ADSs, being the part of Dr. Gillis'
         transaction       total fees that are paid in ADSs for the period of
                           service from July 1 to September 30, 2016.        
                                                                             
    c)   Price(s) and              Price(s)                 Volume(s)        
         volume(s)                                                           
                                   $194.99                     48            
                                                                             
    d)   Aggregated        N/A (single transaction)                          
         information                                                         
                                                                             
    e)   Date of the       September 30, 2016                                
         transaction                                                         
                                                                             
    f)   Place of the      NASDAQ Global Select Market                       
         transaction                                                         

       

    1.   Details of the person discharging managerial responsibilities       
         ("PDMR") / person closely associated with them ("PCA")              
                                                                             
    a)   Name              David Ginsburg                                    
                                                                             
    2.   Reason for the notification                                         
                                                                             
    a)   Position / status Non-Executive Director - PDMR                     
                                                                             
    b)   Initial           Initial notification                              
         notification /                                                      
         amendment                                                           
                                                                             
    3.   Details of the issuer, emission allowance participant, auction      
         platform, auctioneer or auction monitor                             
                                                                             
    a)   Name              Shire plc                                         
                                                                             
    b)   LEI               54930005LQRLI2UXRQ59                              
                                                                             
    4.   Details of the transaction(s): section to be repeated for (i) each  
         type of instrument; (ii) each type of transaction; (iii) each date; 
         and (iv) each place where transactions have been conducted          
                                                                             
    a)   Description of    Shire plc American Depositary Shares ("ADSs")     
         the financial                                                       
         instrument, type                                                    
         of instrument                                                       
                                                                             
         Identification    ISIN: US82481R1068                                
         code                                                                
                                                                             
    b)   Nature of the     Acquisition of ADSs, being the part of Dr.        
         transaction       Ginsburg's total fees that are paid in ADSs for   
                           the period of service from July 1 to September 30,
                           2016.                                             
                                                                             
    c)   Price(s) and              Price(s)                 Volume(s)        
         volume(s)                                                           
                                   $194.99                     47            
                                                                             
    d)   Aggregated        N/A (single transaction)                          
         information                                                         
                                                                             
    e)   Date of the       September 30, 2016                                
         transaction                                                         
                                                                             
    f)   Place of the      NASDAQ Global Select Market                       
         transaction                                                         

       

    1.   Details of the person discharging managerial responsibilities       
         ("PDMR") / person closely associated with them ("PCA")              
                                                                             
    a)   Name              Sara Mathew                                       
                                                                             
    2.   Reason for the notification                                         
                                                                             
    a)   Position / status Non-Executive Director - PDMR                     
                                                                             
    b)   Initial           Initial notification                              
         notification /                                                      
         amendment                                                           
                                                                             
    3.   Details of the issuer, emission allowance participant, auction      
         platform, auctioneer or auction monitor                             
                                                                             
    a)   Name              Shire plc                                         
                                                                             
    b)   LEI               54930005LQRLI2UXRQ59                              
                                                                             
    4.   Details of the transaction(s): section to be repeated for (i) each  
         type of instrument; (ii) each type of transaction; (iii) each date; 
         and (iv) each place where transactions have been conducted          
                                                                             
    a)   Description of    Shire plc American Depositary Shares ("ADSs")     
         the financial                                                       
         instrument, type                                                    
         of instrument                                                       
                                                                             
         Identification    ISIN: US82481R1068                                
         code                                                                
                                                                             
    b)   Nature of the     Acquisition of ADSs, being the part of Ms.        
         transaction       Mathew's total fees that are paid in ADSs for the 
                           period of service from July 1 to September 30,    
                           2016.                                             
                                                                             
    c)   Price(s) and              Price(s)                 Volume(s)        
         volume(s)                                                           
                                   $194.99                     46            
                                                                             
    d)   Aggregated        N/A (single transaction)                          
         information                                                         
                                                                             
    e)   Date of the       September 30, 2016                                
         transaction                                                         
                                                                             
    f)   Place of the      NASDAQ Global Select Market                       
         transaction                                                         

       

    1.   Details of the person discharging managerial responsibilities       
         ("PDMR") / person closely associated with them ("PCA")              
                                                                             
    a)   Name              Anne Minto                                        
                                                                             
    2.   Reason for the notification                                         
                                                                             
    a)   Position / status Non-Executive Director - PDMR                     
                                                                             
    b)   Initial           Initial notification                              
         notification /                                                      
         amendment                                                           
                                                                             
    3.   Details of the issuer, emission allowance participant, auction      
         platform, auctioneer or auction monitor                             
                                                                             
    a)   Name              Shire plc                                         
                                                                             
    b)   LEI               54930005LQRLI2UXRQ59                              
                                                                             
    4.   Details of the transaction(s): section to be repeated for (i) each  
         type of instrument; (ii) each type of transaction; (iii) each date; 
         and (iv) each place where transactions have been conducted          
                                                                             
    a)   Description of    Shire plc Ordinary Shares of 5 pence each         
         the financial     ("Ordinary Shares")                               
         instrument, type                                                    
         of instrument                                                       
                                                                             
         Identification    ISIN: JE00B2QKY057                                
         code                                                                
                                                                             
    b)   Nature of the     Acquisition of Ordinary Shares, being the part of 
         transaction       Ms. Minto's total fees that are paid in Ordinary  
                           Shares for the period of service from July 1 to   
                           September 30, 2016.                               
                                                                             
    c)   Price(s) and              Price(s)                 Volume(s)        
         volume(s)                                                           
                                    £50.10                     138           
                                                                             
    d)   Aggregated        N/A (single transaction)                          
         information                                                         
                                                                             
    e)   Date of the       September 30, 2016                                
         transaction                                                         
                                                                             
    f)   Place of the      London Stock Exchange (XLON)                      
         transaction                                                         

       

    1.   Details of the person discharging managerial responsibilities       
         ("PDMR") / person closely associated with them ("PCA")              
                                                                             
    a)   Name              Albert Stroucken                                  
                                                                             
    2.   Reason for the notification                                         
                                                                             
    a)   Position / status Non-Executive Director - PDMR                     
                                                                             
    b)   Initial           Initial notification                              
         notification /                                                      
         amendment                                                           
                                                                             
    3.   Details of the issuer, emission allowance participant, auction      
         platform, auctioneer or auction monitor                             
                                                                             
    a)   Name              Shire plc                                         
                                                                             
    b)   LEI               54930005LQRLI2UXRQ59                              
                                                                             
    4.   Details of the transaction(s): section to be repeated for (i) each  
         type of instrument; (ii) each type of transaction; (iii) each date; 
         and (iv) each place where transactions have been conducted          
                                                                             
    a)   Description of    Shire plc American Depositary Shares ("ADSs")     
         the financial                                                       
         instrument, type                                                    
         of instrument                                                       
                                                                             
         Identification    ISIN: US82481R1068                                
         code                                                                
                                                                             
    b)   Nature of the     Acquisition of ADSs, being the part of Mr.        
         transaction       Stroucken's total fees that are paid in ADSs for  
                           the period of service from July 1 to September 30,
                           2016.                                             
                                                                             
    c)   Price(s) and              Price(s)                 Volume(s)        
         volume(s)                                                           
                                   $194.99                     53            
                                                                             
    d)   Aggregated        N/A (single transaction)                          
         information                                                         
                                                                             
    e)   Date of the       September 30, 2016                                
         transaction                                                         
                                                                             
    f)   Place of the      NASDAQ Global Select Market                       
         transaction                                                         

    Oliver Strawbridge

    Senior Assistant Company Secretary

    For further information please contact:

    Investor Relations                                                           
                                                                                 
    Sarah Elton-Farr                    seltonfarr@shire.com   +44 1256 894157   

    NOTES TO EDITORS

    About Shire

    Shire is the leading global biotechnology company focused on serving people
    with rare diseases and other highly specialized conditions. We strive to
    develop best-in-class products, many of which are available in more than 100
    countries, across core therapeutic areas including Hematology, Immunology,
    Neuroscience, Ophthalmics, Lysosomal Storage Disorders, Gastrointestinal /
    Internal Medicine / Endocrine and Hereditary Angioedema; and a growing
    franchise in Oncology.

    Our employees come to work every day with a shared mission: to develop and
    deliver breakthrough therapies for the hundreds of millions of people in the
    world affected by rare diseases and other high-need conditions, and who lack
    effective therapies to live their lives to the fullest.

    www.shire.com