Holding(s) in Company

    July 11, 2016 - Shire plc (LSE: SHP, NASDAQ: SHPG)

    1. Identity of the issuer or the underlying issuer                                         Shire plc
    of existing shares to which voting rights are                                                       
    attached: ii                                                                                        
                                                                                                        
    2 Reason for the notification (please tick the appropriate box or boxes):                           
                                                                                                        
    An acquisition or disposal of voting rights                                                   X     
                                                                                                        
    An acquisition or disposal of qualifying financial instruments which may result                     
    in the acquisition of shares already issued to which voting rights are attached                     
                                                                                                        
    An acquisition or disposal of instruments with similar economic effect to                           
    qualifying financial instruments                                                                    
                                                                                                        
    An event changing the breakdown of voting rights                                                    
                                                                                                        
    Other (please        Decrease in voting rights ownership due to company increase in           X     
    specify):            shares outstanding                                                             
                                                                                                        
    3. Full name of person(s) subject to the                                   Harbor International Fund
    notification obligation: iii                         (a series of Harbor Funds, a Delaware Statutory
                                                                                                  Trust)
                                                                                                        
    4. Full name of shareholder(s)                                                                      
     (if different from 3.):iv                                                                          
                                                                                                        
    5. Date of the transaction and date on                                     Trade Date: June 30, 2016
    which the threshold is crossed or                                      Settlement Date: July 5, 2016
    reached: v                                                                                          
                                                                                                        
    6. Date on which issuer notified:                                                       July 8, 2016
                                                                                                        
    7. Threshold(s) that is/are crossed or                                  3% of issuer's voting rights
    reached: vi, vii                                                                                    
                                                                                                        

       

    8. Notified details:                                                                                   
                                                                                                           
    A: Voting rights attached to shares viii, ix                                                           
                                                                                                           
    Class/type of    Situation previous       Resulting situation after the triggering transaction         
    shares           to the triggering                                                                     
                     transaction                                                                           
    if possible                                                                                            
    using            Number       Number      Number       Number of voting        % of  voting rights x   
    the ISIN CODE    of           of          of shares    rights                                          
                     Shares       Voting                                                                   
                                  Rights      Direct       Direct xi     Indirect  Direct       Indirect   
                                                                         xii                               
                                                                                                           
    Common           19,156,536   19,156,536  19,156,536   19,156,536       N/A       2.13%         N/A    
    SEDOL: B2QKY05                                                                                         
                                                                                                           
    B: Qualifying Financial Instruments                                                                    
                                                                                                           
    Resulting situation after the triggering transaction                                                   
                                                                                                           
    Type of financial      Expiration   Exercise/               Number of voting         % of voting       
    instrument             date xiii    Conversion Period xiv   rights that may be       rights            
                                                                acquired if the                            
                                                                instrument is                              
                                                                exercised/ converted.                      
                                                                                                           
                                                                                                           
             N/A               N/A                N/A                     N/A                   N/A        
                                                                                                           
    C: Financial Instruments with similar economic effect to Qualifying Financial                          
    Instruments xv, xvi                                                                                    
                                                                                                           
    Resulting situation after the triggering transaction                                                   
                                                                                                           
    Type of financial Exercise    Expiration   Exercise/       Number of voting       % of voting rights   
    instrument        price       date xvii    Conversion      rights instrument      xix, xx              
                                               period xviii    refers to                                   
                                                                                                           
           N/A            N/A         N/A            N/A                N/A           Nominal      Delta   
                                                                                                           
                                                                                          N/A        N/A   
                                                                                                           
    Total (A+B+C)                                                                                          
                                                                                                           
    Number of voting rights                          Percentage of voting rights                           
                                                                                                           
    19,156,536                                       2.13%                                                 
                                                                                                           

       

    9. Chain of controlled undertakings through which the voting rights and/or the              
    financial instruments are effectively held, if applicable: xxi                              
                                                                                                
                                                                                                
    N/A                                                                                         
                                                                                                
    Proxy Voting:                                                                               
                                                                                                
    10. Name of the proxy holder:                                            N/A                
                                                                                                
    11. Number of voting rights proxy holder will cease                      N/A                
    to hold:                                                                                    
                                                                                                
    12. Date on which proxy holder will cease to hold                        N/A                
    voting rights:                                                                              
                                                                                                
                                                                                                
    13. Additional information:                              Completed in Chicago, Illinois, USA
                                                                                 on July 8, 2016
                                                                                                
    14. Contact name:                                                          Jodie L. Crotteau
                                                                             Assistant Secretary
                                                                                                
    15. Contact telephone number:                                                   312-443-4428
                                                                                                

    For further information please contact:

    Investor Relations                                                                
                                                                                      
    Sarah Elton-Farr                         seltonfarr@shire.com +44 1256 894157     

    NOTES TO EDITORS

    Shire is the leading global biotechnology company focused on serving people
    with rare diseases and other highly specialized conditions. We strive to
    develop best-in-class products, many of which are available in more than 100
    countries across core therapeutic areas including Hematology, Immunology,
    Neuroscience, Lysosomal Storage Disorders, Gastrointestinal / Internal Medicine
    / Endocrine and Hereditary Angioedema; a growing franchise in Oncology; and an
    emerging, innovative pipeline in Ophthalmics.

    Our employees come to work every day with a shared mission: to develop and
    deliver breakthrough therapies for the hundreds of millions of people in the
    world affected by rare diseases and other high-need conditions, and who lack
    effective therapies to live their lives to the fullest.

    www.shire.com