Shire to announce third quarter 2016 results

    Dublin, Ireland - October 19, 2016 - Shire plc (LSE: SHP, NASDAQ: SHPG), will
    announce third quarter 2016 earnings on Tuesday November 1, 2016.

    Results press release will be      12:00 GMT / 08:00 EDT                     
    issued at:                                                                   
                                                                                 
    Investor conference call time:     14:00 GMT / 10:00 EDT                     

    Live conference call for investors:

    Flemming Ornskov, MD, Chief Executive Officer and Jeff Poulton, Chief Financial
    Officer will host the investor and analyst conference call at 10:00 EDT / 14:00
    GMT.

    The details of the conference call are as follows:

    UK dial in:                  0808 237 0030 or 020 3139 4830                 
                                                                                
    US dial in:                  1 866 928 7517 or 1 718 873 9077               
                                                                                
    International Access         http://events.arkadin.com/ev/docs/             
    Numbers:                     NE_FEL_Events_International_Access_List.pdf    
                                                                                
    Password/Conf ID:            42020034#                                      
                                                                                
    Live Webcast:                http://investors.shire.com/quarterly-results/  

    Replay:

    A replay of the presentation will be available for two weeks by phone and by
    webcast for three months.  Replay information can be found on the Investor
    Relations section of Shire's website at http://investors.shire.com/.

    For further information please contact:

    Investor Relations                                                           
                                                                                 
    Sarah Elton-Farr                      seltonfarr@shire.com +44 1256 894157   
                                                                                 
    Ian Karp                              ikarp@shire.com      +1 781 482 9018   
                                                                                 
    Robert Coates                         rcoates@shire.com    +44 1256 894874   

    Notes to editors

    About Shire

    Shire is the leading global biotechnology company focused on serving people
    with rare diseases and other highly specialized conditions. We strive to
    develop best-in-class products, many of which are available in more than 100
    countries, across core therapeutic areas including Hematology, Immunology,
    Neuroscience, Ophthalmics, Lysosomal Storage Disorders, Gastrointestinal /
    Internal Medicine / Endocrine and Hereditary Angioedema; and a growing
    franchise in Oncology.

    Our employees come to work every day with a shared mission: to develop and
    deliver breakthrough therapies for the hundreds of millions of people in the
    world affected by rare diseases and other high-need conditions, and who lack
    effective therapies to live their lives to the fullest.

    www.shire.com