Results of the 2016 Annual General Meeting

    April 28, 2016 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company") announces
    that, at its Annual General Meeting held at The Merrion Hotel, Upper Merrion
    Street, Dublin 2, Ireland at 11.30am today, all resolutions contained in the
    Notice of Meeting were decided by poll vote. The results of the poll are as
    follows:

    Resolutions                    For         %       Against      %       Votes    Withheld 
                               (including                                 cast as a           
                              discretionary                                 % of              
                                 votes)                                   relevant            
                                                                          shares in           
                                                                            issue             
                                                                                              
    Ordinary Resolutions                                                                      
                                                                                              
    1. To receive the         470,025,424   98.71%   6,142,245   1.29%    80.26%    291,113   
    Company's Annual Report                                                                   
    and Accounts for the year                                                                 
    ended December 31, 2015.                                                                  
                                                                                              
    2. To approve the         235,249,661   50.55%   230,154,350 49.45%   78.45%    11,054,771
    Directors' Remuneration                                                                   
    Report.                                                                                   
                                                                                              
    3. To re-elect Dominic    470,121,989   98.70%   6,207,408   1.30%    80.29%    129,385   
    Blakemore as a Director.                                                                  
                                                                                              
    4. To elect Olivier       466,427,485   97.92%   9,905,128   2.08%    80.29%    126,169   
    Bohuon as a Director.                                                                     
                                                                                              
    5. To re-elect William    470,549,161   98.79%   5,783,700   1.21%    80.29%    125,921   
    Burns as a Director.                                                                      
                                                                                              
    6. To re-elect Dr. Steven 468,848,644   98.43%   7,483,905   1.57%    80.29%    126,233   
    Gillis as a Director.                                                                     
                                                                                              
    7. To re-elect Dr. David  474,415,296   99.60%   1,917,736   0.40%    80.29%    125,750   
    Ginsburg as a Director.                                                                   
                                                                                              
    8. To re-elect Susan      463,855,077   97.38%   12,478,702  2.62%    80.29%    125,003   
    Kilsby as a Director.                                                                     
                                                                                              
    9. To elect Sara Mathew   469,790,821   98.63%   6,542,652   1.37%    80.29%    125,309   
    as a Director.                                                                            
                                                                                              
    10. To re-elect Anne      466,021,105   98.89%   5,252,483   1.11%    79.44%    5,185,194 
    Minto as a Director.                                                                      
                                                                                              
    11. To re-elect Dr.       474,415,807   99.60%   1,919,364   0.40%    80.29%    123,611   
    Flemming Ornskov as a                                                                     
    Director.                                                                                 
                                                                                              
    12. To elect Jeffrey      470,866,225   98.85%   5,468,257   1.15%    80.29%    124,300   
    Poulton as a Director.                                                                    
                                                                                              
    13. To re-appoint         454,250,728   96.38%   17,054,940  3.62%    79.44%    5,153,114 
    Deloitte LLP as the                                                                       
    Company's Auditor.                                                                        
                                                                                              
    14. To authorize the      462,464,490   97.53%   11,710,617  2.47%    79.93%    2,283,675 
    Audit, Compliance & Risk                                                                  
    Committee to determine                                                                    
    the remuneration of the                                                                   
    Auditor.                                                                                  
                                                                                              
    15. To authorize the      440,997,344   92.79%   34,255,367  7.21%    80.11%    1,206,071 
    allotment of shares.                                                                      
                                                                                              
    Special Resolutions                                                                       
                                                                                              
    16. To authorize the      446,395,797   94.39%   26,542,021  5.61%    79.72%    3,520,964 
    disapplication of                                                                         
    pre-emption rights.                                                                       
                                                                                              
    17. To authorize          470,214,310   98.72%   6,115,636   1.28%    80.29%    128,836   
    purchases of own shares.                                                                  
                                                                                              
    18. To increase the       465,305,718   97.69%   11,024,146  2.31%    80.29%    128,918   
    authorized share capital.                                                                 
                                                                                              
    19. To adopt new Articles 451,403,800   97.16%   13,173,422  2.84%    78.31%    11,881,560
    of Association.                                                                           
                                                                                              
    20. To approve the notice 429,265,355   90.61%   44,462,801  9.39%    79.85%    2,730,626 
    period for general                                                                        
    meetings.                                                                                 

    The Board is pleased to have secured the support of our shareholders for all
    resolutions. We have engaged extensively with our major shareholders on the
    remuneration report and acknowledge the vote today. We remain firmly committed
    to a constructive and appropriate dialogue to fully understand shareholder
    views as we compete in a global market place.

    As at the record date, April 26, 2016, the Company had 593,249,631 Ordinary
    Shares of 5 pence each in issue (excluding shares held in treasury).
    Shareholders are entitled to one vote per share. A vote "withheld" is not a
    vote in law and is not counted in the calculation of the proportion of votes
    validly cast.

    In accordance with Listing Rule 9.6.2R copies of the relevant resolutions
    passed at the meeting have been submitted to the National Storage Mechanism and
    will be available for viewing shortly at: www.morningstar.co.uk/uk/nsm.

    Oliver Strawbridge
    Senior Assistant Company Secretary

    For further information please contact:

    Investor Relations                                                           
                                                                                 
    Sarah Elton-Farr                    seltonfarr@shire.com   +44 1256 894157   

    NOTES TO EDITORS

    Shire enables people with life-altering conditions to lead better lives.

    Our strategy is to focus on developing and marketing innovative specialty
    medicines to meet significant unmet patient needs.

    We focus on providing treatments in Rare Diseases, Neuroscience,
    Gastrointestinal and Internal Medicine and we are developing treatments for
    symptomatic conditions treated by specialist physicians in other targeted
    therapeutic areas, such as Ophthalmics.

    www.shire.com