Result of Meeting                               

              Shire Shareholders Vote to Approve combination WITH BAXALTA          

    Combination Would Create the Global Leader in Rare Diseases

    Transaction Expected to Close on June 3rd  

    Dublin, Ireland - May 27, 2016 - Shire plc (LSE: SHP, NASDAQ: SHPG) today
    announces that, at a general meeting convened for the purpose, its shareholders
    have approved proposals relating to Shire's combination with Baxalta
    Incorporated, which would create the leading global biotechnology company in
    rare diseases and other highly specialized conditions.

    Shire Chief Executive Officer, Flemming Ornskov, M.D., M.P.H., commented: "We
    are pleased to take this important step toward completing our combination with
    Baxalta, and are grateful that our shareholders have voiced their support by
    approving this transaction. The combination will allow us to realize our goal
    of building the leading global biotechnology company focused on rare diseases
    and other highly specialized conditions, offering greater opportunities for our
    patients, healthcare partners and employees. As our teams continue to plan our
    integration, we anticipate a smooth and timely transition for all of our
    stakeholders, and I am excited about what we will be able to achieve together
    for the benefit of our patients worldwide."  

    Under the merger agreement, at closing Baxalta shareholders will receive $18.00
    in cash and either 0.1482 Shire ADSs or 0.4446 Shire Ordinary shares per
    Baxalta share.

    The completion of the transaction remains subject to approval by Baxalta
    shareholders, with a vote scheduled to occur at 7:00 am CST today, and other
    customary closing conditions. Shire expects the transaction will complete on
    June 3, 2016.

    At the general meeting, all resolutions contained in the Notice of Meeting were
    decided by poll vote. The results of the poll are as follows:

    Resolutions                 For         %       Against      %     Votes cast  Withheld 
                            (including                                  as a % of           
                           discretionary                                relevant            
                              votes)                                    shares in           
                                                                          issue             
                                                                                            
    Ordinary Resolutions                                                                    
                                                                                            
    1. To approve the       420,340,630   93.81%  27,724,473   6.19%     75.52%    1,713,032
    Merger, allotment of                                                                    
    shares and increase in                                                                  
    borrowing limit.                                                                        
                                                                                            
    2. To authorize the     414,970,708   92.35%  34,377,524   7.65%     75.73%     429,903 
    allotment of shares.                                                                    
                                                                                            
    Special Resolutions                                                                     
                                                                                            
    3. To authorize the     416,265,573   93.36%  29,598,188   6.64%     75.15%    3,914,374
    disapplication of                                                                       
    pre-emption rights.                                                                     
                                                                                            
    4. To authorize         437,094,810   97.28%  12,225,243   2.72%     75.73%     458,082 
    purchases of own                                                                        
    shares.                                                                                 

    As at the record date, May 25, 2016, the Company had 593,337,139 Ordinary
    Shares of 5 pence each in issue (excluding shares held in treasury).
    Shareholders are entitled to one vote per share. A vote "withheld" is not a
    vote in law and is not counted in the calculation of the proportion of votes
    validly cast.

    In accordance with Listing Rule 9.6.2R copies of the relevant resolutions
    passed at the meeting have been submitted to the National Storage Mechanism and
    will be available for viewing shortly at: www.morningstar.co.uk/uk/nsm.

    About Shire

    Shire enables people with life-altering conditions to lead better lives.

    Shire's strategy is to focus on developing and marketing innovative specialty
    medicines to meet significant unmet patient needs.

    Shire's focus is on providing treatments in Rare Diseases, Neuroscience,
    Gastrointestinal and Internal Medicine and we are developing treatments for
    symptomatic conditions treated by specialist physicians in other targeted
    therapeutic areas, such as Ophthalmics.

    FOR FURTHER INFORMATION PLEASE CONTACT:

                                                                                                     
    FOR SHIRE                                                                                        
                                                                                                     
    Investor Relations                                                                               
                                                                                                     
    Sarah Elton-Farr        seltonfarr@shire.com          +44 1256 894157                            
                                                                                                     
    Robert Coates           rcoates@shire.com             +44 1256 894874                            
                                                                                                     
    Ian Karp                ikarp@shire.com               +1 781 482 9018                            
                                                                                                     
    Media                                                                                            
                                                                                                     
    Michele Galen           mgalen@shire.com              +1 781 482 1867                            
                                                                                                     
    Brooke Clarke           brclarke@shire.com            +44 1256 894829                            
                                                                                                     
    FTI Consulting (Media Advisor to the Company)                                                    
                                                                                                     
    Ben Atwell (London)                 ben.atwell@fticonsulting.com                        +44 20   
                                                                                            3727 1000
                                                                                                     
    David Roady (New York)              david.roady@fticonsulting.com                       +1 212   
    Robert Stanislaro (New York)        robert.stanislaro@fticonsulting.com                 850 5600 
                                                                                            +1 212   
                                                                                            850 5600 

    Forward-Looking Statements

    Statements included herein that are not historical facts, including without
    limitation statements concerning the financial and strategic benefits of our
    combination with Baxalta, our 20x20 ambition that targets $20 billion in
    combined product sales by 2020, as well as other targets for future financial
    results, capital structure, performance and sustainability of the combined
    company, the combined company's future strategy, plans, objectives,
    expectations and intentions, the anticipated timing of clinical trials and
    approvals for, and the commercial potential of, inline or pipeline products are
    forward-looking statements. Such forward-looking statements involve a number of
    risks and uncertainties and are subject to change at any time. In the event
    such risks or uncertainties materialize, Shire's results could be materially
    adversely affected. The risks and uncertainties include, but are not limited
    to, the following:

      * disruption from the acquisition and integration of Baxalta may make it more
        difficult to conduct business as usual or maintain relationships with
        patients, physicians, employees or suppliers;
      * the company may not achieve some or all of the anticipated benefits of
        Baxalta's spin-off from Baxter International, Inc. ("Baxter") and the
        acquisition may have an adverse impact on Baxalta's existing arrangements
        with Baxter, including those related to transition, manufacturing and
        supply services and tax matters;
      * the failure to achieve the strategic objectives with respect to the
        acquisition of Baxalta may adversely affect the company's financial
        condition and results of operations;
      * products and product candidates may not achieve commercial success;
      * product sales from ADDERALL XR and INTUNIV are subject to generic
        competition;
      * the failure to obtain and maintain reimbursement, or an adequate level of
        reimbursement, by third-party payers in a timely manner for the company's
        products may affect future revenues, financial condition and results of
        operations, particularly if there is pressure on pricing of products to
        treat rare diseases;
      * supply chain or manufacturing disruptions may result in declines in revenue
        for affected products and commercial traction from competitors; regulatory
        actions associated with product approvals or changes to manufacturing
        sites, ingredients or manufacturing processes could lead to significant
        delays, an increase in operating costs, lost product sales, an interruption
        of research activities or the delay of new product launches;
      * the successful development of products in various stages of research and
        development is highly uncertain and requires significant expenditures and
        time, and there is no guarantee that these products will receive regulatory
        approval;
      * the actions of certain customers could affect the company's ability to sell
        or market products profitably, and fluctuations in buying or distribution
        patterns by such customers can adversely affect the company's revenues,
        financial condition or results of operations;
      * investigations or enforcement action by regulatory authorities or law
        enforcement agencies relating to the company's activities in the highly
        regulated markets in which it operates may result in significant legal
        costs and the payment of substantial compensation or fines;
      * adverse outcomes in legal matters, tax audits and other disputes, including
        the company's ability to enforce and defend patents and other intellectual
        property rights required for its business, could have a material adverse
        effect on the company's revenues, financial condition or results of
        operations;
      * Shire is undergoing a corporate reorganization and was the subject of an
        unsuccessful acquisition proposal and the consequent uncertainty could
        adversely affect the company's ability to attract and/or retain the highly
        skilled personnel needed to meet its strategic objectives;
      * failure to achieve the strategic objectives with respect to Shire's
        acquisition of NPS Pharmaceuticals Inc. or Dyax Corp. ("Dyax") may
        adversely affect the company's financial condition and results of
        operations;
      * the company is dependent on information technology and its systems and
        infrastructure face certain risks, including from service disruptions, the
        loss of sensitive or confidential information, cyber-attacks and other
        security breaches or data leakages that could have a material adverse
        effect on the company's revenues, financial condition or results of
        operations;
      * the company may be unable to retain and hire key personnel and/or maintain
        its relationships with customers, suppliers and other business partners;
      * difficulties in integrating Dyax or Baxalta into Shire may lead to the
        company not being able to realize the expected operating efficiencies, cost
        savings, revenue enhancements, synergies or other benefits at the time
        anticipated or at all; and

    other risks and uncertainties detailed from time to time in Shire's,  Dyax's or
    Baxalta's filings with the Securities and Exchange Commission, including those
    risks outlined in "ITEM 1A: Risk Factors" in Shire's and Baxalta's Annual
    Reports on Form 10-K for the year ended December 31, 2015.

    All forward-looking statements attributable to us or any person acting on our
    behalf are expressly qualified in their entirety by this cautionary statement.
    Readers are cautioned not to place undue reliance on these forward-looking
    statements that speak only as of the date hereof. Except to the extent
    otherwise required by applicable law, we do not undertake any obligation to
    republish revised forward-looking statements to reflect events or circumstances
    after the date hereof or to reflect the occurrence of unanticipated events.