Block Listing Six Monthly Return

May 26, 2015 - Shire plc (LSE: SHP, NASDAQ: SHPG)

Name of applicant: Shire plc
Name of scheme: 2000 Executive Share Option Scheme
Period of return: From: November 23, 2014 To: May 22, 2015
Balance of unallotted securities under 3,406,623
scheme(s) from previous return:
Plus: The amount by which the block scheme Nil
(s) has been increased since the date of
the last return (if any increase has been
applied for):
Less: Number of securities issued/allotted Nil
under scheme(s) during period (see
LR3.5.7G):
Equals: Balance under scheme(s) not yet 3,406,623*
issued/allotted at end of period:

*There are no further awards outstanding under the 2000 Executive Share Option
Scheme and therefore these shares have been cancelled.

Name of applicant: Shire plc
Name of scheme: Shire Sharesave Scheme
Period of return: From: November 23, 2014 To: May 22, 2015
Balance of unallotted securities under 207,758
scheme(s) from previous return:
Plus: The amount by which the block scheme Nil
(s) has been increased since the date of
the last return (if any increase has been
applied for):
Less: Number of securities issued/allotted 4,207
under scheme(s) during period (see
LR3.5.7G):
Equals: Balance under scheme(s) not yet 203,551
issued/allotted at end of period:


Name of applicant: Shire plc
Name of scheme: Shire Portfolio Share Plan
Period of return: From: November 23, 2014 To: May 22, 2015
Balance of unallotted securities under 1,138,214
scheme(s) from previous return:
Plus: The amount by which the block scheme 2,000,000
(s) has been increased since the date of
the last return (if any increase has been
applied for):
Less: Number of securities issued/allotted 1,353,145
under scheme(s) during period (see
LR3.5.7G):
Equals: Balance under scheme(s) not yet 1,785,069
issued/allotted at end of period:


Name of applicant: Shire plc
Name of scheme: Shire Employee Stock Purchase Plan
Period of return: From: November 23, 2014 To: May 22, 2015
Balance of unallotted securities under 524,710
scheme(s) from previous return:
Plus: The amount by which the block scheme Nil
(s) has been increased since the date of
the last return (if any increase has been
applied for):
Less: Number of securities issued/allotted 2,373
under scheme(s) during period (see
LR3.5.7G):
Equals: Balance under scheme(s) not yet 522,337
issued/allotted at end of period:


Name of applicant: Shire plc
Name of scheme: Shire Long Term Incentive Plan 2015
Period of return: From: May 13, 2015 To: May 22, 2015
Balance of unallotted securities under Nil
scheme(s) from previous return:
Plus: The amount by which the block scheme 3,000,000
(s) has been increased since the date of
the last return (if any increase has been
applied for):
Less: Number of securities issued/allotted Nil
under scheme(s) during period (see
LR3.5.7G):
Equals: Balance under scheme(s) not yet 3,000,000
issued/allotted at end of period:


Name of contact: Tony Guthrie, Deputy Company Secretary
Address of contact: Hampshire International Business Park
Basingstoke, Hampshire, RG24 8EP
Telephone number of contact: 01256 894746

For further information please contact:

Investor Relations
Sarah Elton-Farr seltonfarr@shire.com +44 1256 894157

NOTES TO EDITORS

Shire enables people with life-altering conditions to lead better lives.

Our strategy is to focus on developing and marketing innovative specialty
medicines to meet significant unmet patient needs.

We focus on providing treatments in Rare Diseases, Neuroscience,
Gastrointestinal and Internal Medicine and we are developing treatments for
symptomatic conditions treated by specialist physicians in other targeted
therapeutic areas, such as Ophthalmics.


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