Director Share Dealings

September 30, 2014 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company")
announces that today Ordinary Shares ("Shares") and American Depository Shares
("ADSs") of the Company, as set out below, have been acquired for the
Non-Executive Directors, being the part of their total fees that are paid in
shares for the period of service from July 1 to September 30, 2014.

                         Type of Security(1)     Number of Shares/ADSs

Dominic Blakemore              Shares                            98

William Burns                  Shares                            99

Dr. Steven Gillis               ADSs                             32

Dr. David Ginsburg              ADSs                             30

David Kappler                  Shares                           104

Susan Kilsby                    ADSs                            100

Anne Minto                     Shares                           104

David Stout                     ADSs                             32

(1) One ADS is equal to three Shares

The Shares and ADSs were acquired on the London Stock Exchange and NASDAQ
respectively at prices of £53.45 per Share and $259.9747 per ADS.

This notification relates to disclosures made in accordance with 3.1.4(R)(1)(a)
of the Disclosure and Transparency Rules.

Tony Guthrie
Deputy Company Secretary

For further information please contact:

Investor Relations
Jeff Poulton                            jpoulton@shire.com   +1 781 482 0945
Sarah Elton-Farr                        seltonfarr@shire.com +44 1256 894157

Media
Stephanie Fagan                         sfagan@shire.com     +1 781 482 0460
Gwen Fisher                             gfisher@shire.com    +1 484 595 9836

NOTES TO EDITORS

Shire enables people with life-altering conditions to lead better lives.

Our strategy is to focus on developing and marketing innovative specialty
medicines to meet significant unmet patient needs.

We focus on providing treatments in Neuroscience, Rare Diseases,
Gastrointestinal, and Internal Medicine and we are developing treatments for
symptomatic conditions treated by specialist physicians in other targeted
therapeutic areas, such as Ophthalmology.

www.shire.com


Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX

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