FORM 8.3

PUBLIC OPENING POSITION DISCLOSURE/DEALING DISCLOSURE BY

A PERSON WITH INTERESTS IN RELEVANT SECURITIES REPRESENTING 1% OR MORE

Rule 8.3 of the Takeover Code (the "Code")

1. KEY INFORMATION

(a) Identity of the person whose positions/dealings are being disclosed

FMR LLC and/or one or more of its direct or indirect subsidiaries

And

FIL Limited and/or one or more of its direct and indirect subsidiaries

(b) Owner or controller of interests and short positions disclosed, if different from 1(a):

The naming of nominee or vehicle companies is insufficient


(c) Name of offeror/offeree in relation to whose relevant securities this form relates:

Use a separate form for each offeror/offeree

ABBVIE INC

(d) If an exempt fund manager connected with an offeror/offeree, state this and specify identity of offeror/offeree


(e) Date position held/dealing undertaken

21-July-14

(f) Has the discloser previously disclosed, or are they today disclosing, under the Code in respect of any other party to this offer?

YES

If YES, specify which:

Shire Plc

2. POSITIONS OF THE PERSON MAKING THE DISCLOSURE

(a) Interests and short positions in the relevant securities of the offeror or offeree to which the disclosure relates following the dealing (if any)

Class of relevant security:

Ordinary Shares


Interests

Short positions


Number

(%)

Number

(%)

(1) Relevant securities owned and/or controlled:

68,353,066

4.29%



2) Derivatives (other than options):

138,411

0.01%



(3) Options and agreements to purchase/sell



2,000

0.00%

TOTAL

68,491,477

4.30%

2,000

0.00%

All interests and all short positions should be disclosed.

Details of any open derivative or option positions, or agreements to purchase or sell relevant securities, should be given on a Supplemental Form 8 (Open Positions).

(b) Rights to subscribe for new securities (including directors' and other executive options)

Class of relevant security in relation to which subscription right exists:


Details, including nature of the rights concerned and relevant percentages:


If there are positions or rights to subscribe to disclose in more than one class of relevant securities of the offeror or offeree named in 1(c), copy table 2(a) or (b) (as appropriate) for each additional class of relevant security.

3. DEALINGS (IF ANY) BY THE PERSON MAKING THE DISCLOSURE

(a) Purchases and sales

Class of relevant security

Purchase/sale

Number of securities

Price per unit

Ordinary shares

Buy

47,200

54.0594 USD/ Share

Ordinary shares

Buy

90,000

54.1119 USD/ Share

Ordinary shares

Buy

20,374

54.3515 USD/ Share

Ordinary shares

Buy

118

54.05 USD/ Share

Ordinary shares

Buy

16,400

54.2681 USD/ Share

Ordinary shares

Buy

5,200

54.3614 USD/ Share

Ordinary shares

Sale

2,300

54.095 USD/ Share

Ordinary shares

Buy

7,000

54.3718 USD/ Share

Ordinary shares

Buy

35

54.00 USD/ Share

Ordinary shares

Sale

248

54.37 US/ Share

Ordinary shares

Buy

26

54.38 USD/ Share

Ordinary shares

Sale

224

53.51 USD/ Share

Ordinary shares

Sale

52

54.96 USD/ Share

Ordinary shares

Buy

10

54.97 USD/ Share

Ordinary shares

Buy

4

53.52 USD/ Share

Ordinary shares

Buy

1

55.04 USD/ Share

Ordinary shares

Sale

1

54.36 USD/ Share

(b) Derivatives transactions (other than options)

Class of relevant security

Product description

e.g. CFD

Nature of dealing e.g. opening/closing a long/short position, increasing/reducing a long/short position

Number of reference securities

Price per unit





(c) Options transactions in respect of existing securities

(i) Writing, selling, purchasing or varying

Class of relevant security

Product description e.g. call option

Writing, purchasing, selling, varying etc.

Number of securities to which option relates

Exercise price per unit

Type

e.g. American, European etc.

Expiry date

Option money paid/ received per unit









(ii) Exercising

Class of relevant security

Product description

e.g. call option

Number of securities

Exercise price per unit




(d) Other dealings (including new securities)

Class of relevant security

Nature of dealing

e.g. subscription, conversion

Details

Price per unit (if applicable)




The currency of all prices and other monetary amounts should be stated.

Where there have been dealings in more than one class of relevant securities of the offeror or offeree named in 1(c), copy table 3(a), (b), (c) or (d) (as appropriate) for each additional class of relevant security dealt in.

4. OTHER INFORMATION

(a) Indemnity and other dealing arrangements

Details of any indemnity or option arrangement, or any agreement or understanding, formal or informal, relating to relevant securities which may be an inducement to deal or refrain from dealing entered into by the person making the disclosure and any party to the offer or any person acting in concert with a party to the offer:

If there are no such agreements, arrangements or understandings, state "none"

(b) Agreements, arrangements or understandings relating to options or derivatives

Details of any agreement, arrangement or understanding, formal or informal, between the person making the disclosure and any other person relating to:

(i) the voting rights of any relevant securities under any option; or

(ii) the voting rights or future acquisition or disposal of any relevant securities to which any derivative is referenced:

If there are no such agreements, arrangements or understandings, state "none"

(c) Attachments

Is a Supplemental Form 8 (Open Positions) attached?

YES

SUPPLEMENTAL FORM 8 (OPEN POSITIONS)

DETAILS OF OPEN OPTION AND DERIVATIVE POSITIONS, AGREEMENTS TO PURCHASE OR SELL ETC.

Note 5(i) on Rule 8 of the Takeover Code (the "Code")

1. KEY INFORMATION

Identity of person whose open positions are being disclosed:

ABBVIE INC

Name of offeror/offeree in relation to whose relevant securities the disclosure relates:

Shire PLC

2. OPTIONS AND DERIVATIVES

Class of relevant security

Product description e.g. call option

Written or purchased

Number of securities to which option or derivative relates

Exercise price per unit

Type

e.g. American, European etc.

Expiry date

CS

Call Option

Written

1,000

USD 57.50

American

16 Aug 2014

CS

Call Option

Written

500

USD 60.00

American

16 Aug 2014

CS

Call Option

Written

500

USD 62.50

American

22 Nov 2014

Date of disclosure

22-July-14

Contact name

Nina Collomosse

Telephone number

01737 837092

Public disclosures under Rule 8 of the Code must be made to a Regulatory Information Service and must also be emailed to the Takeover Panel atmonitoring@disclosure.org.uk. The Panel's Market Surveillance Unit is available for consultation in relation to the Code's dealing disclosure requirements on +44 (0)20 7638 0129.

The Code can be viewed on the Panel's website atwww.thetakeoverpanel.org.uk.


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