FORM 8.3

PUBLIC OPENING POSITION DISCLOSURE/DEALING DISCLOSURE BY

A PERSON WITH INTERESTS IN RELEVANT SECURITIES REPRESENTING 1% OR MORE

Rule 8.3 of the Takeover Code (the "Code")

1. KEY INFORMATION

(a) Identity of the person whose positions/dealings are being disclosed:

Barclays PLC.

(b) Owner or controller of interests and short positions disclosed, if different from 1(a):

The naming of nominee or vehicle companies is insufficient

(c) Name of offeror/offeree in relation to whose relevant securities this form relates:

Use a separate form for each offeror/offeree

SHIRE PLC

(d) If an exempt fund manager connected with an offeror/offeree, state this and specify identity of offeror/offeree:
(e) Date position held/dealing undertaken:

29 September 2014

(f) Has the discloser previously disclosed, or are they today disclosing, under the Code in respect of any other party to this offer?

YES:

ABBVIE INC

2. POSITIONS OF THE PERSON MAKING THE DISCLOSURE

(a) Interests and short positions in the relevant securities of the offeror or offeree to which the disclosure relates following the dealing (if any)

Class of relevant security: ORD
Interests Short Positions
Number (%) Number (%)
(1) Relevant securities owned
and/or controlled: 10,794,235 1.83% 4,702,939 0.80%
(2) Derivatives (other than
options): 2,120,650 0.36% 3,814,658 0.65%
(3) Options and agreements to
purchase/sell: 1,557,300 0.26% 1,931,700 0.33%
(4)
TOTAL: 14,472,185 2.45% 10,449,297 1.78%

All interests and all short positions should be disclosed.

Details of any open derivative or option positions, or agreements to purchase or sell relevant securities, should be given on a Supplemental Form 8 (Open Positions).

(b) Rights to subscribe for new securities (including directors' and other executive options)

Class of relevant security in relation to which subscription right exists:
Details, including nature of the rights concerned and relevant percentages:

If there are positions or rights to subscribe to disclose in more than one class of relevant securities of the offeror or offeree named in 1(c), copy table 2(a) or (b) (as appropriate) for each additional class of relevant security.

3. DEALINGS (IF ANY) BY THE PERSON MAKING THE DISCLOSURE

(a) Purchases and sales

Class of relevant Purchase/sale Number of Price per unit
security securities
ORD Purchase 6 52.9500 GBP
ORD (traded as ADR) Purchase 30 260.2000 USD
ORD (traded as ADR) Purchase 57 262.6400 USD
ORD (traded as ADR) Purchase 60 260.3400 USD
ORD Purchase 69 53.5500 GBP
ORD (traded as ADR) Purchase 108 260.9016 USD
ORD Purchase 145 53.0500 GBP
ORD (traded as ADR) Purchase 150 260.4280 USD
ORD Purchase 184 53.7500 GBP
ORD Purchase 189 53.2500 GBP
ORD Purchase 235 54.0000 GBP
ORD Purchase 265 53.3000 GBP
ORD (traded as ADR) Purchase 300 260.0397 USD
ORD (traded as ADR) Purchase 300 262.5700 USD
ORD (traded as ADR) Purchase 300 262.8200 USD
ORD (traded as ADR) Purchase 330 259.8472 USD
ORD (traded as ADR) Purchase 351 259.6327 USD
ORD Purchase 370 53.3500 GBP
ORD (traded as ADR) Purchase 390 262.7230 USD
ORD Purchase 527 53.1410 GBP
ORD (traded as ADR) Purchase 579 260.2884 USD
ORD (traded as ADR) Purchase 600 260.5700 USD
ORD (traded as ADR) Purchase 600 260.7950 USD
ORD (traded as ADR) Purchase 600 260.8260 USD
ORD (traded as ADR) Purchase 600 262.1900 USD
ORD (traded as ADR) Purchase 600 262.5600 USD
ORD (traded as ADR) Purchase 600 262.5650 USD
ORD (traded as ADR) Purchase 600 262.8650 USD
ORD Purchase 628 53.6000 GBP
ORD Purchase 637 53.2000 GBP
ORD Purchase 659 53.1000 GBP
ORD (traded as ADR) Purchase 720 260.4083 USD
ORD (traded as ADR) Purchase 738 262.0687 USD
ORD (traded as ADR) Purchase 891 261.2730 USD
ORD (traded as ADR) Purchase 900 262.7400 USD
ORD Purchase 1,097 53.0189 GBP
ORD (traded as ADR) Purchase 1,200 261.2220 USD
ORD Purchase 1,295 53.4073 GBP
ORD Purchase 1,340 53.1500 GBP
ORD Purchase 1,359 53.2822 GBP
ORD Purchase 1,472 53.1216 GBP
ORD (traded as ADR) Purchase 1,710 261.3130 USD
ORD Purchase 1,789 53.1572 GBP
ORD Purchase 1,943 53.7727 GBP
ORD (traded as ADR) Purchase 2,013 260.9100 USD
ORD (traded as ADR) Purchase 2,100 260.1402 USD
ORD (traded as ADR) Purchase 2,100 262.7599 USD
ORD (traded as ADR) Purchase 2,154 262.1346 USD
ORD (traded as ADR) Purchase 2,244 261.8890 USD
ORD (traded as ADR) Purchase 2,364 261.2502 USD
ORD Purchase 2,400 53.7916 GBP
ORD (traded as ADR) Purchase 2,481 261.4546 USD
ORD (traded as ADR) Purchase 2,700 260.9304 USD
ORD (traded as ADR) Purchase 3,000 261.8476 USD
ORD Purchase 3,681 53.1986 GBP
ORD (traded as ADR) Purchase 3,885 261.9880 USD
ORD (traded as ADR) Purchase 3,900 260.0986 USD
ORD Purchase 3,967 53.7583 GBP
ORD Purchase 4,197 53.7134 GBP
ORD (traded as ADR) Purchase 8,100 261.4254 USD
ORD Purchase 8,456 53.6766 GBP
ORD (traded as ADR) Purchase 8,637 261.3268 USD
ORD (traded as ADR) Purchase 9,012 260.6942 USD
ORD (traded as ADR) Purchase 9,210 262.6153 USD
ORD Purchase 15,782 53.1167 GBP
ORD Purchase 18,001 53.3268 GBP
ORD (traded as ADR) Purchase 18,804 261.3202 USD
ORD (traded as ADR) Purchase 23,304 260.6700 USD
ORD Purchase 45,656 53.2595 GBP
ORD Purchase 60,073 53.1498 GBP
ORD Purchase 117,689 53.1645 GBP
ORD Purchase 224,499 53.1846 GBP
ORD Sale 6 52.9500 GBP
ORD Sale 13 53.3115 GBP
ORD (traded as ADR) Sale 57 262.6400 USD
ORD (traded as ADR) Sale 63 260.5071 USD
ORD Sale 69 53.5500 GBP
ORD (traded as ADR) Sale 108 260.9016 USD
ORD (traded as ADR) Sale 120 261.0553 USD
ORD Sale 145 53.0500 GBP
ORD Sale 184 53.7500 GBP
ORD Sale 189 53.2500 GBP
ORD (traded as ADR) Sale 300 259.7300 USD
ORD (traded as ADR) Sale 300 260.0400 USD
ORD (traded as ADR) Sale 300 260.2600 USD
ORD (traded as ADR) Sale 300 260.7120 USD
ORD (traded as ADR) Sale 300 260.8700 USD
ORD Sale 314 53.6000 GBP
ORD Sale 370 53.3500 GBP
ORD (traded as ADR) Sale 384 260.6700 USD
ORD Sale 421 53.1000 GBP
ORD (traded as ADR) Sale 492 260.6134 USD
ORD (traded as ADR) Sale 600 260.6450 USD
ORD (traded as ADR) Sale 600 260.8260 USD
ORD (traded as ADR) Sale 600 262.0400 USD
ORD Sale 637 53.1485 GBP
ORD Sale 637 53.2000 GBP
ORD (traded as ADR) Sale 900 261.7193 USD
ORD (traded as ADR) Sale 900 262.7400 USD
ORD Sale 960 53.1348 GBP
ORD (traded as ADR) Sale 1,200 260.4100 USD
ORD (traded as ADR) Sale 1,200 261.5245 USD
ORD (traded as ADR) Sale 1,275 261.5264 USD
ORD Sale 1,340 53.1500 GBP
ORD (traded as ADR) Sale 1,500 261.8476 USD
ORD Sale 1,630 53.3673 GBP
ORD (traded as ADR) Sale 2,400 260.0890 USD
ORD Sale 2,649 53.7047 GBP
ORD Sale 3,986 53.2629 GBP
ORD Sale 4,335 53.6019 GBP
ORD Sale 5,648 52.9107 GBP
ORD (traded as ADR) Sale 5,700 261.5034 USD
ORD Sale 5,808 53.6570 GBP
ORD (traded as ADR) Sale 6,996 260.7884 USD
ORD (traded as ADR) Sale 7,800 260.0986 USD
ORD (traded as ADR) Sale 7,824 261.4517 USD
ORD Sale 8,492 53.1428 GBP
ORD Sale 12,772 53.1346 GBP
ORD (traded as ADR) Sale 14,100 262.6423 USD
ORD (traded as ADR) Sale 21,078 261.3759 USD
ORD Sale 23,012 53.4464 GBP
ORD (traded as ADR) Sale 26,343 261.5573 USD
ORD Sale 41,211 53.2794 GBP
ORD Sale 54,897 53.1367 GBP
ORD Sale 105,878 53.1567 GBP
ORD Sale 168,487 53.1711 GBP
(b) Derivatives transactions (other than options)
Class of Product Nature of dealing Number of Price per
relevant description reference unit
security securities
ORD SWAP Long 188 53.1260 GBP
ORD CFD Long 2,744 53.2069 GBP
ORD CFD Long 3,000 53.0016 GBP
ORD SWAP Long 8,909 53.3161 GBP
ORD CFD Short 48 53.4000 GBP
ORD CFD Short 527 53.1410 GBP
ORD SWAP Short 1,097 53.0189 GBP
ORD CFD Short 1,295 53.4073 GBP
ORD CFD Short 3,809 53.1723 GBP
ORD SWAP Short 8,444 53.2337 GBP
ORD CFD Short 14,038 53.0683 GBP
ORD SWAP Short 44,022 53.3193 GBP

(c) Options transactions in respect of existing securities

(i) Writing, selling, purchasing or varying

Class of relevant security Product description e.g. call option Writing, purchasing, selling, varying etc. Number of securities to which option relates Exercise price per unit Type

e.g. American, European etc.

Expiry date Option money paid/ received per unit

(ii) Exercising

Class of relevant security Product description

e.g. call option

Number of securities Exercise price per unit

(d) Other dealings (including subscribing for new securities)

Class of relevant security Nature of dealing

e.g. subscription, conversion

Details Price per unit (if applicable)

The currency of all prices and other monetary amounts should be stated.

Where there have been dealings in more than one class of relevant securities of the offeror or offeree named in 1(c), copy table 3(a), (b), (c) or (d) (as appropriate) for each additional class of relevant security dealt in.

4. OTHER INFORMATION

(a) Indemnity and other dealing arrangements

Details of any indemnity or option arrangement, or any agreement or understanding, formal or informal, relating to relevant securities which may be an inducement to deal or refrain from dealing entered into by the person making the disclosure and any party to the offer or any person acting in concert with a party to the offer:

If there are no such agreements, arrangements or understandings, state "none"

NONE

(b) Agreements, arrangements or understandings relating to options or derivatives

Details of any agreement, arrangement or understanding, formal or informal, between the person making the disclosure and any other person relating to:

(i) the voting rights of any relevant securities under any option; or

(ii) the voting rights or future acquisition or disposal of any relevant securities to which any derivative is referenced:

If there are no such agreements, arrangements or understandings, state "none"

NONE

(c) Attachments

Is a Supplemental Form 8 (Open Positions) attached?

YES

Date of disclosure:

30 September 2014

Contact name:

Rajesh Muthanna

Telephone number:

020 3555 4634

Public disclosures under Rule 8 of the Code must be made to a Regulatory Information Service and must also be emailed to the Takeover Panel at monitoring@disclosure.org.uk. The Panel's Market Surveillance Unit is available for consultation in relation to the Code's dealing disclosure requirements on +44 (0)20 7638 0129.

The Code can be viewed on the Panel's website at www.thetakeoverpanel.org.uk.

SUPPLEMENTAL FORM 8 (OPEN POSITIONS)

DETAILS OF OPEN OPTION AND DERIVATIVE POSITIONS, AGREEMENTS TO PURCHASE OR SELL ETC.

Note 5(i) on Rule 8 of the Takeover Code (the "Code")

1. KEY INFORMATION

Identity of person whose open positions are being disclosed:

Barclays PLC.

Name of offeror/offeree in relation to whose relevant securities the disclosure relates:

SHIRE PLC

2. OPTIONS AND DERIVATIVES

Class Product Writing, Number Exercise Type Expiry
of description purchasing, of price date
relevant selling, securities per unit
security varying etc to which
option
relates
ADR Put Options Purchased -300 160.0000 American 18 Oct 2014
ADR Put Options Purchased -2,100 160.0000 American 17 Jan 2015
ADR Put Options Purchased -2,900 185.0000 American 17 Jan 2015
ADR Put Options Purchased -900 210.0000 American 17 Jan 2015
ADR Put Options Purchased -200 220.0000 American 17 Jan 2015
ADR Put Options Purchased -26,600 240.0000 American 18 Oct 2014
ADR Put Options Purchased -10,000 245.0000 American 18 Oct 2014
ADR Put Options Purchased -1,100 260.0000 American 18 Oct 2014
ADR Put Options Purchased -300 265.0000 American 17 Jan 2015
ADR Put Options Purchased -600 270.0000 American 17 Jan 2015
ADR Put Options Purchased -1,000 275.0000 American 17 Apr 2015
ADR Put Options Purchased -2,000 285.0000 American 17 Jan 2015
ADR Put Options Purchased -1,000 290.0000 American 17 Apr 2015
ADR Put Options Purchased -1,100 300.0000 American 17 Apr 2015
ADR Put Options Written 1,000 100.0000 American 17 Jan 2015
ADR Put Options Written 100 130.0000 American 17 Jan 2015
ADR Put Options Written 100 140.0000 American 18 Oct 2014
ADR Put Options Written 300 145.0000 American 18 Oct 2014
ADR Put Options Written 300 150.0000 American 18 Oct 2014
ADR Put Options Written 1,100 165.0000 American 18 Oct 2014
ADR Put Options Written 500 170.0000 American 18 Oct 2014
ADR Put Options Written 6,100 175.0000 American 18 Oct 2014
ADR Put Options Written 300 180.0000 American 18 Oct 2014
ADR Put Options Written 1,500 190.0000 American 18 Oct 2014
ADR Put Options Written 100 190.0000 American 17 Jan 2015
ADR Put Options Written 700 195.0000 American 18 Oct 2014
ADR Put Options Written 5,100 200.0000 American 18 Oct 2014
ADR Put Options Written 300 205.0000 American 18 Oct 2014
ADR Put Options Written 13,100 215.0000 American 17 Jan 2015
ADR Put Options Written 30,700 220.0000 American 18 Oct 2014
ADR Put Options Written 1,000 220.0000 American 17 Apr 2015
ADR Put Options Written 1,700 230.0000 American 18 Oct 2014
ADR Put Options Written 2,700 230.0000 American 17 Jan 2015
ADR Put Options Written 100 235.0000 American 18 Oct 2014
ADR Put Options Written 100 235.0000 American 17 Jan 2015
ADR Put Options Written 2,200 245.0000 American 18 Oct 2014
ADR Put Options Written 300 275.0000 American 18 Oct 2014
ADR Put Options Written 300 280.0000 American 18 Oct 2014
ADR Put Options Written 100 280.0000 American 17 Apr 2015
ADR Call Options Purchased 1,800 165.0000 American 18 Oct 2014
ADR Call Options Purchased 1,000 215.0000 American 18 Oct 2014
ADR Call Options Purchased 15,900 225.0000 American 18 Oct 2014
ADR Call Options Purchased 2,800 225.0000 American 17 Jan 2015
ADR Call Options Purchased 6,000 230.0000 American 17 Jan 2015
ADR Call Options Purchased 3,600 235.0000 American 18 Oct 2014
ADR Call Options Purchased 1,000 250.0000 American 18 Oct 2014
ADR Call Options Purchased 200 255.0000 American 18 Oct 2014
ADR Call Options Purchased 8,300 260.0000 American 18 Oct 2014
ADR Call Options Purchased 15,600 260.0000 American 17 Jan 2015
ADR Call Options Purchased 3,000 265.0000 American 18 Oct 2014
ADR Call Options Purchased 10,300 265.0000 American 17 Jan 2015
ADR Call Options Purchased 100 270.0000 American 18 Oct 2014
ADR Call Options Purchased 374,600 270.0000 American 17 Jan 2015
ADR Call Options Purchased 3,300 275.0000 American 17 Jan 2015
ADR Call Options Purchased 1,500 280.0000 American 17 Jan 2015
ADR Call Options Purchased 100 285.0000 American 17 Jan 2015
ADR Call Options Purchased 100 300.0000 American 17 Apr 2015
ADR Call Options Purchased 100 305.0000 American 17 Apr 2015
ADR Call Options Written -1,200 155.0000 American 18 Oct 2014
ADR Call Options Written -2,200 160.0000 American 18 Oct 2014
ADR Call Options Written -5,800 175.0000 American 18 Oct 2014
ADR Call Options Written -200 180.0000 American 18 Oct 2014
ADR Call Options Written -200 180.0000 American 17 Jan 2015
ADR Call Options Written -200 185.0000 American 17 Jan 2015
ADR Call Options Written -1,100 190.0000 American 18 Oct 2014
ADR Call Options Written -2,300 195.0000 American 18 Oct 2014
ADR Call Options Written -200 195.0000 American 17 Jan 2015
ADR Call Options Written -1,300 195.0000 American 15 Jan 2016
ADR Call Options Written -2,000 200.0000 American 18 Oct 2014
ADR Call Options Written -200 210.0000 American 18 Oct 2014
ADR Call Options Written -300 210.0000 American 17 Jan 2015
ADR Call Options Written -57,600 220.0000 American 18 Oct 2014
ADR Call Options Written -300 220.0000 American 17 Jan 2015
ADR Call Options Written -8,400 225.0000 American 17 Jan 2015
ADR Call Options Written -1,900 230.0000 American 18 Oct 2014
ADR Call Options Written -3,500 230.0000 American 17 Jan 2015
ADR Call Options Written -1,000 235.0000 American 18 Oct 2014
ADR Call Options Written -2,800 235.0000 American 17 Jan 2015
ADR Call Options Written -100 240.0000 American 18 Oct 2014
ADR Call Options Written -99,200 240.0000 American 17 Jan 2015
ADR Call Options Written -4,800 245.0000 American 17 Jan 2015
ADR Call Options Written -23,700 250.0000 American 17 Jan 2015
ADR Call Options Written -372,700 255.0000 American 17 Jan 2015
ADR Call Options Written -100 255.0000 American 17 Apr 2015
ADR Call Options Written -100 320.0000 American 17 Jan 2015
ADR Call Options Written -400 330.0000 American 17 Jan 2015

3. AGREEMENTS TO PURCHASE OR SELL ETC.

Full details should be given so that the nature of the interest or position can be fully understood:

It is not necessary to provide details on a Supplemental Form (Open Positions) with regard to contracts for differences ("CFDs") or spread bets.

The currency of all prices and other monetary amounts should be stated.

The Panel's Market Surveillance Unit is available for consultation in relation to the Code's dealing disclosure requirements on +44 (0)20 7638 0129.

The Code can be viewed on the Panel's website at www.thetakeoverpanel.org.uk.

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