FORM 8.3

PUBLIC OPENING POSITION DISCLOSURE/DEALING DISCLOSURE BY

A PERSON WITH INTERESTS IN RELEVANT SECURITIES REPRESENTING 1% OR MORE

Rule 8.3 of the Takeover Code (the "Code")

1. KEY INFORMATION

(a) Identity of the person whose positions/dealings are being disclosed:

Nomura International Plc

(b) Owner or controller of interests and short positions disclosed, if different from 1(a):

The naming of nominee or vehicle companies is insufficient


(c) Name of offeror/offeree in relation to whose relevant securities this form relates:

Use a separate form for each offeror/offeree

Shire Plc

(d) If an exempt fund manager connected with an offeror/offeree, state this and specify identity of offeror/offeree:


(e) Date position held/dealing undertaken:

16 Sep 2014

(f) Has the discloser previously disclosed, or are they today disclosing, under the Code in respect of any other party to this offer?

Yes, AbbVie Inc

2. POSITIONS OF THE PERSON MAKING THE DISCLOSURE

(a) Interests and short positions in the relevant securities of the offeror or offeree to which the disclosure relates following the dealing (if any)

Class of relevant security:


Interests

Short positions

Number

%

Number

%

(1) Relevant securities owned and/or controlled:

1,785,731

0.303

209,984

0.036

(2) Derivatives (other than options):

10,259

0.002

1,649,305

0.280

(3) Options and agreements to purchase/sell:

6,282,000

1.066

5,508,000

0.934

TOTAL:

8,077,990

1.371

7,367,289

1.250

All interests and all short positions should be disclosed.

Details of any open derivative or option positions, or agreements to purchase or sell relevant securities, should be given on a Supplemental Form 8 (Open Positions).

(b) Rights to subscribe for new securities (including directors' and other executive options)

Class of relevant security in relation to which subscription right exists:


Details, including nature of the rights concerned and relevant percentages:


If there are positions or rights to subscribe to disclose in more than one class of relevant securities of the offeror or offeree named in 1(c), copy table 2(a) or (b) (as appropriate) for each additional class of relevant security.

3. DEALINGS (IF ANY) BY THE PERSON MAKING THE DISCLOSURE

(a) Purchases and sales

Class of relevant security

Purchase/sale

Number of securities

Price per unit

Ordinary Shares

Purchase

2,577

52.2973

Ordinary Shares

Purchase

197

52.5000

Ordinary Shares

Purchase

32

52.5250

Ordinary Shares

Purchase

93

52.5500

Ordinary Shares

Purchase

129,661

52.6256

Ordinary Shares

Purchase

568

52.7050

Ordinary Shares

Purchase

603

52.7229

Ordinary Shares

Purchase

432

52.8500

Ordinary Shares

Sale

2,577

52.7516

Ordinary Shares

Sale

129,661

52.7750

Ordinary Shares

Sale

499

52.7785

Ordinary Shares

Sale

1,027

52.7842

Total Buy - 134,163

Total Sell - 133,764

(b) Derivatives transactions (other than options)

Class of relevant security

Product description

e.g. CFD

Nature of dealing

e.g. opening/closing a long/short position, increasing/reducing a long/short position

Number of reference securities

Price per unit

Ordinary Shares

SWAP

Long

2,577

52.5914

Ordinary Shares

SWAP

Long

129,661

52.6424

Ordinary Shares

SWAP

Long

499

52.7257

Ordinary Shares

SWAP

Long

1,431

52.7482

Ordinary Shares

SWAP

Long

1,027

52.8483

Ordinary Shares

SWAP

Short

2,577

52.2921

Ordinary Shares

SWAP

Short

129,661

52.6256

Ordinary Shares

SWAP

Short

568

52.6997

Ordinary Shares

SWAP

Short

603

52.7190

Ordinary Shares

SWAP

Short

320

52.7659

Ordinary Shares

SWAP

Short

807

52.8447

(c) Options transactions in respect of existing securities

(i) Writing, selling, purchasing or varying

Class of relevant security

Product description e.g. call option

Writing, purchasing, selling, varying etc.

Number of securities to which option relates

Exercise price per unit

Type

e.g. American, European etc.

Expiry date

Option money paid/ received per unit








(ii) Exercising

Class of relevant security

Product description

e.g. call option

Number of securities

Exercise price per unit




(d) Other dealings (including subscribing for new securities)

Class of relevant security

Nature of dealing

e.g. subscription, conversion

Details

Price per unit (if applicable)





The currency of all prices and other monetary amounts should be stated.

Where there have been dealings in more than one class of relevant securities of the offeror or offeree named in 1(c), copy table 3(a), (b), (c) or (d) (as appropriate) for each additional class of relevant security dealt in.

4. OTHER INFORMATION

(a) Indemnity and other dealing arrangements

Details of any indemnity or option arrangement, or any agreement or understanding, formal or informal, relating to relevant securities which may be an inducement to deal or refrain from dealing entered into by the person making the disclosure and any party to the offer or any person acting in concert with a party to the offer:

If there are no such agreements, arrangements or understandings, state "none"

(b) Agreements, arrangements or understandings relating to options or derivatives

Details of any agreement, arrangement or understanding, formal or informal, between the person making the disclosure and any other person relating to:

(i) the voting rights of any relevant securities under any option; or

(ii) the voting rights or future acquisition or disposal of any relevant securities to which any derivative is referenced:

If there are no such agreements, arrangements or understandings, state "none"

(c) Attachments

Is a Supplemental Form 8 (Open Positions) attached?

YES

SUPPLEMENTAL FORM 8 (OPEN POSITIONS)

DETAILS OF OPEN OPTION AND DERIVATIVE POSITIONS, AGREEMENTS TO PURCHASE OR SELL ETC.

Note 5(i) on Rule 8 of the Takeover Code (the "Code")

1. KEY INFORMATION

Identity of person whose open positions are being disclosed:

Nomura International Plc

Name of offeror/offeree in relation to whose relevant securities the disclosure relates:

Shire Plc

2. OPTIONS AND DERIVATIVES

Class of relevant security

Product description e.g. call option

Written or purchased

Number of securities to which option or derivative relates

Exercise price per unit in EUR

Type

e.g. American, European etc.

Expiry date

Ordinary Shares

Call Option

Purchased

5,000

4400.0000

American

19-Dec-14

Ordinary Shares

Call Option

Purchased

10,000

4600.0000

American

19-Dec-14

Ordinary Shares

Call Option

Purchased

75,000

265.0000

American

18-Oct-14

Ordinary Shares

Put Option

Written

100,000

4200.0000

American

19-Sep-14

Ordinary Shares

Put Option

Written

125,000

3600.0000

American

19-Dec-14

Ordinary Shares

Call Option

Purchased

150,000

260.0000

American

18-Oct-14

Ordinary Shares

Put Option

Written

600,000

200.0000

American

18-Oct-14

Ordinary Shares

Call Option

Purchased

633,000

255.0000

American

17-Jan-15

Ordinary Shares

Call Option

Purchased

645,000

255.0000

American

17-Apr-15

Ordinary Shares

Call Option

Purchased

789,000

3600.0000

American

19-Dec-14

Ordinary Shares

Call Option

Purchased

789,000

4800.0000

American

19-Dec-14

Ordinary Shares

Call Option

Purchased

1,095,000

255.0000

American

17-Apr-15

Ordinary Shares

Call Option

Purchased

1,266,000

255.0000

American

16-Jan-15

Ordinary Shares

Put Option

Purchased

2,000

3400.0000

American

19-Dec-14

Ordinary Shares

Put Option

Purchased

15,000

3400.0000

American

19-Sep-14

Ordinary Shares

Put Option

Purchased

125,000

4200.0000

American

19-Dec-14

Ordinary Shares

Call Option

Written

150,000

270.0000

American

18-Oct-14

Ordinary Shares

Call Option

Written

633,000

280.0000

American

17-Jan-15

Ordinary Shares

Call Option

Written

645,000

275.0000

American

17-Apr-15

Ordinary Shares

Call Option

Written

1,577,000

4200.0000

American

19-Dec-14

Ordinary Shares

Call Option

Written

1,095,000

280.0000

American

17-Apr-15

Ordinary Shares

Call Option

Written

1,266,000

280.0000

American

16-Jan-15

3. AGREEMENTS TO PURCHASE OR SELL ETC.

Full details should be given so that the nature of the interest or position can be fully understood:

It is not necessary to provide details on a Supplemental Form (Open Positions) with regard to contracts for differences ("CFDs") or spread bets.

The currency of all prices and other monetary amounts should be stated.

The Panel's Market Surveillance Unit is available for consultation in relation to the Code's dealing disclosure requirements on +44 (0)20 7638 0129.

The Code can be viewed on the Panel's website atwww.thetakeoverpanel.org.uk.

Date of disclosure:

17 Sep 2014

Contact name:

Kyere Tabiri

Telephone number:

020 7102 1267

Public disclosures under Rule 8 of the Code must be made to a Regulatory Information Service and must also be emailed to the Takeover Panel atmonitoring@disclosure.org.uk. The Panel's Market Surveillance Unit is available for consultation in relation to the Code's dealing disclosure requirements on +44 (0)20 7638 0129.

The Code can be viewed on the Panel's website atwww.thetakeoverpanel.org.uk.


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