Shire : Form 8.5 (EPT/NON-RI) - Amendment

September 23, 2014 at 02:16 am EDT

Amendment - due to the amendment of Derivative transactions, the disclosure made on 18 September for dealings on 17 September has been updated. Sections 3(b) and the Supplemental Form have been updated.

FORM 8.5 (EPT/NON-RI)

PUBLIC OPENING POSITION DISCLOSURE/DEALING DISCLOSURE BY AN EXEMPT PRINCIPAL TRADER WITHOUT RECOGNISED INTERMEDIARY ("RI") STATUS (OR WHERE RI STATUS IS NOT APPLICABLE)

Rule 8.5 of the Takeover Code (the "Code")

1. KEY INFORMATION

(a) Name of exempt principal trader:	(GS) GOLDMAN, SACHS & CO.
(b) Name of offeror/offeree in relation to whose relevant securities this form relates: Use a separate form for each offeror/offeree	SHIRE PLC
(c) Name of the party to the offer with which exempt principal trader is connected:	SHIRE PLC
(d) Date position held/dealing undertaken:	17 September 2014
(e) Has the EPT previously disclosed, or is it today disclosing, under the Code in respect of any other party to this offer?	NO

2. POSITIONS OF THE EXEMPT PRINCIPAL TRADER

(a) Interests and short positions in the relevant securities of the offeror or offeree to which the disclosure relates following the dealing (if any)

Class of relevant security:	5p ordinary and ADRs
	Interests		Short positions
	Number	%	Number	%
(1) Relevant securities owned and/or controlled:	590,532	0.10	188,034	0.03
(2) Derivatives (other than options):	0	0.00	66,129	0.01
(3) Options and agreements to purchase/sell:	0	0.00	0	0.00
TOTAL:	590,532	0.10	254,163	0.04

All interests and all short positions should be disclosed.

Details of any open derivative or option positions, or agreements to purchase or sell relevant securities, should be given on a Supplemental Form 8 (Open Positions).

(b) Rights to subscribe for new securities (including directors' and other executive options)

Class of relevant security in relation to which subscription right exists:
Details, including nature of the rights concerned and relevant percentages:

If there are positions or rights to subscribe to disclose in more than one class of relevant securities of the offeror or offeree named in 1(b), copy table 2(a) or (b) (as appropriate) for each additional class of relevant security.

3. DEALINGS (IF ANY) BY THE EXEMPT PRINCIPAL TRADER

(a) Purchases and sales

Class of relevant security	Purchase/sale	Number of securities	Price per unit
ADR / (1.00 : 3.00)	Purchase	16 (48)	260.0900 USD
ADR / (1.00 : 3.00)	Purchase	16 (48)	260.0900 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.0900 USD
ADR / (1.00 : 3.00)	Purchase	16 (48)	260.1000 USD
ADR / (1.00 : 3.00)	Purchase	23 (69)	260.1000 USD
ADR / (1.00 : 3.00)	Purchase	77 (231)	260.1000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.1900 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.2500 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.2500 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.2500 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.2500 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.2600 USD
ADR / (1.00 : 3.00)	Purchase	200 (600)	260.2600 USD
ADR / (1.00 : 3.00)	Purchase	200 (600)	260.2600 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.2600 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.2600 USD
ADR / (1.00 : 3.00)	Purchase	200 (600)	260.2600 USD
ADR / (1.00 : 3.00)	Purchase	200 (600)	260.2600 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.2600 USD
ADR / (1.00 : 3.00)	Purchase	10 (30)	260.2600 USD
ADR / (1.00 : 3.00)	Purchase	200 (600)	260.2600 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.2600 USD
ADR / (1.00 : 3.00)	Purchase	200 (600)	260.2600 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.2600 USD
ADR / (1.00 : 3.00)	Purchase	200 (600)	260.2600 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.2600 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.2600 USD
ADR / (1.00 : 3.00)	Purchase	200 (600)	260.2600 USD
ADR / (1.00 : 3.00)	Purchase	200 (600)	260.2600 USD
ADR / (1.00 : 3.00)	Purchase	200 (600)	260.2600 USD
ADR / (1.00 : 3.00)	Purchase	200 (600)	260.2600 USD
ADR / (1.00 : 3.00)	Purchase	200 (600)	260.2600 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.2600 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.2600 USD
ADR / (1.00 : 3.00)	Purchase	10 (30)	260.2600 USD
ADR / (1.00 : 3.00)	Purchase	90 (270)	260.2600 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.2600 USD
ADR / (1.00 : 3.00)	Purchase	200 (600)	260.2600 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.2600 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.2600 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.2600 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.2600 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.2600 USD
ADR / (1.00 : 3.00)	Purchase	200 (600)	260.2600 USD
ADR / (1.00 : 3.00)	Purchase	190 (570)	260.2600 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.2600 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.2600 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.2600 USD
ADR / (1.00 : 3.00)	Purchase	200 (600)	260.2600 USD
ADR / (1.00 : 3.00)	Purchase	6,826 (20,478)	260.2826 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.2900 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.2900 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.2900 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.2900 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.2900 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.3000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.3000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.3000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.3000 USD
ADR / (1.00 : 3.00)	Purchase	200 (600)	260.3000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.3000 USD
ADR / (1.00 : 3.00)	Purchase	200 (600)	260.3000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.3000 USD
ADR / (1.00 : 3.00)	Purchase	200 (600)	260.3000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.3000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.3000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.3000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.3000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.3100 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.3100 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.3100 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.3100 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.3100 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.3100 USD
ADR / (1.00 : 3.00)	Purchase	200 (600)	260.3100 USD
ADR / (1.00 : 3.00)	Purchase	200 (600)	260.3100 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.3100 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.3100 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.3100 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.3100 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.3200 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.3200 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.3500 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.3500 USD
ADR / (1.00 : 3.00)	Purchase	67 (201)	260.3500 USD
ADR / (1.00 : 3.00)	Purchase	200 (600)	260.3500 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.3500 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.3700 USD
ADR / (1.00 : 3.00)	Purchase	33 (99)	260.3700 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.3800 USD
ADR / (1.00 : 3.00)	Purchase	200 (600)	260.3800 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.3800 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.4300 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.4500 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.4600 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.4600 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.4600 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.4800 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.5000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.6500 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.6600 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.6700 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.6900 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.6900 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.7000 USD
ADR / (1.00 : 3.00)	Purchase	52 (156)	260.7300 USD
ADR / (1.00 : 3.00)	Purchase	17 (51)	260.7400 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.7400 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.7600 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.7600 USD
ADR / (1.00 : 3.00)	Purchase	200 (600)	260.7600 USD
ADR / (1.00 : 3.00)	Purchase	200 (600)	260.7600 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.7600 USD
ADR / (1.00 : 3.00)	Purchase	83 (249)	260.7600 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.7600 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.7600 USD
ADR / (1.00 : 3.00)	Purchase	200 (600)	260.7600 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.7600 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.9800 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.9800 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.9800 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	260.9900 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.0000 USD
ADR / (1.00 : 3.00)	Purchase	11 (33)	261.4000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.4600 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.4600 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.4600 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.4600 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.4600 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.5000 USD
ADR / (1.00 : 3.00)	Purchase	61 (183)	261.5000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.5000 USD
ADR / (1.00 : 3.00)	Purchase	62 (186)	261.5000 USD
ADR / (1.00 : 3.00)	Purchase	90 (270)	261.5500 USD
ADR / (1.00 : 3.00)	Purchase	10 (30)	261.5500 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.6400 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.6400 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.6400 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.6400 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.6400 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.6400 USD
ADR / (1.00 : 3.00)	Purchase	161 (483)	261.6400 USD
ADR / (1.00 : 3.00)	Purchase	200 (600)	261.6400 USD
ADR / (1.00 : 3.00)	Purchase	98 (294)	261.6400 USD
ADR / (1.00 : 3.00)	Purchase	39 (117)	261.6500 USD
ADR / (1.00 : 3.00)	Purchase	2 (6)	261.6500 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.6500 USD
ADR / (1.00 : 3.00)	Purchase	200 (600)	261.6500 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.6500 USD
ADR / (1.00 : 3.00)	Purchase	200 (600)	261.6700 USD
ADR / (1.00 : 3.00)	Purchase	200 (600)	261.6700 USD
ADR / (1.00 : 3.00)	Purchase	300 (900)	261.6700 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.6700 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.6700 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.6700 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.6900 USD
ADR / (1.00 : 3.00)	Purchase	10 (30)	261.6900 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.6900 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.6900 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.6900 USD
ADR / (1.00 : 3.00)	Purchase	71 (213)	261.7000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.7800 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.7900 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.7900 USD
ADR / (1.00 : 3.00)	Purchase	29 (87)	261.7900 USD
ADR / (1.00 : 3.00)	Purchase	71 (213)	261.7900 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.8500 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.8700 USD
ADR / (1.00 : 3.00)	Purchase	10 (30)	261.8700 USD
ADR / (1.00 : 3.00)	Purchase	200 (600)	261.8700 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.9400 USD
ADR / (1.00 : 3.00)	Purchase	80 (240)	261.9400 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.9600 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.9600 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.9700 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.9700 USD
ADR / (1.00 : 3.00)	Purchase	95 (285)	261.9700 USD
ADR / (1.00 : 3.00)	Purchase	200 (600)	261.9800 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.9800 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.9800 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.9800 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.9800 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.9800 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.9800 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	261.9900 USD
ADR / (1.00 : 3.00)	Purchase	20 (60)	262.0000 USD
ADR / (1.00 : 3.00)	Purchase	120 (360)	262.0000 USD
ADR / (1.00 : 3.00)	Purchase	180 (540)	262.0000 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	262.0200 USD
ADR / (1.00 : 3.00)	Purchase	46 (138)	262.0200 USD
ADR / (1.00 : 3.00)	Purchase	34 (102)	262.0400 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	262.0500 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	262.0600 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	262.0600 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	262.0600 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	262.0600 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	262.0600 USD
ADR / (1.00 : 3.00)	Purchase	100 (300)	262.0800 USD
ADR / (1.00 : 3.00)	Sale	6,826 (20,478)	260.2826 USD
ADR / (1.00 : 3.00)	Sale	2,774 (8,322)	260.2826 USD
ADR / (1.00 : 3.00)	Sale	11,500 (34,500)	260.8458 USD
ADR / (1.00 : 3.00)	Sale	7,500 (22,500)	261.7714 USD

Class of relevant security	Purchases/sales	Total number of securities
ADR / (1.00 : 3.00)	Purchases	35,426 (106,278)
ADR / (1.00 : 3.00)	Sales	28,600 (85,800)

(b) Derivatives transactions (other than options)

Class of relevant security	Product description e.g. CFD	Nature of dealing e.g. opening/closing a long/short position, increasing/reducing a long/short position	Number of reference securities	Price per unit
ADR / (1.00 : 3.00)	SWAP / (1.00 : 3.00)	Increasing a short position	3,163 (9,489)	260.2826 USD
ADR / (1.00 : 3.00)	SWAP / (1.00 : 3.00)	Increasing a short position	2,692 (8,076)	260.2826 USD
ADR / (1.00 : 3.00)	SWAP / (1.00 : 3.00)	Increasing a short position	956 (2,868)	260.2826 USD
ADR / (1.00 : 3.00)	SWAP / (1.00 : 3.00)	Increasing a short position	15 (45)	260.2826 USD

(i) Writing, selling, purchasing or varying

Class of relevant security

Product description e.g. call option

Writing, purchasing, selling, varying etc.

Number of securities to which option relates

Exercise price per unit

Type

e.g. American, European etc.

Expiry date

Option money paid/ received per unit

(ii) Exercising

Class of relevant security

Product description

e.g. call option

Number of securities

Exercise price per unit

(d) Other dealings (including subscribing for new securities)

Class of relevant security

Nature of dealing

e.g. subscription, conversion

Details

Price per unit (if applicable)

The currency of all prices and other monetary amounts should be stated.

Where there have been dealings in more than one class of relevant securities of the offeror or offeree named in 1(b), copy table 3(a), (b), (c) or (d) (as appropriate) for each additional class of relevant security dealt in.

4. OTHER INFORMATION

(a) Indemnity and other dealing arrangements

Details of any indemnity or option arrangement, or any agreement or understanding, formal or informal, relating to relevant securities which may be an inducement to deal or refrain from dealing entered into by the exempt principal trader making the disclosure and any party to the offer or any person acting in concert with a party to the offer:

If there are no such agreements, arrangements or understandings, state "none"

NONE

(b) Agreements, arrangements or understandings relating to options or derivatives

Details of any agreement, arrangement or understanding, formal or informal, between the exempt principal trader making the disclosure and any other person relating to:

(i) the voting rights of any relevant securities under any option; or

(ii) the voting rights or future acquisition or disposal of any relevant securities to which any derivative is referenced:

If there are no such agreements, arrangements or understandings, state "none"

NONE

Is a Supplemental Form 8 (Open Positions) attached?

YES

Date of disclosure:	22 September 2014
Contact name:	Aadithya Rao and Yiannis Bardis
Telephone number:	+44(20) 7051 9046 / +44(20) 7774 7107

Public disclosures under Rule 8 of the Code must be made to a Regulatory Information Service and must also be emailed to the Takeover Panel at monitoring@disclosure.org.uk. The Panel's Market Surveillance Unit is available for consultation in relation to the Code's dealing disclosure requirements on +44 (0)20 7638 0129.

The Code can be viewed on the Panel's website atwww.thetakeoverpanel.org.uk.

SUPPLEMENTAL FORM 8(OPEN POSITIONS)

DETAILS OF OPEN OPTION AND DERIVATIVE POSITIONS, AGREEMENT TO

PURCHASE OR SELL ETC.

Note 5(i) on Rule 8 of the Takeover Code (the "Code")

1. KEY INFORMATION

Identity of the person whose open positions are being disclosed:	(GS) GOLDMAN, SACHS & CO.
Name of offeror/offeree in relation to whose relevant securities disclosure relates:	SHIRE PLC

2. OPTIONS AND DERIVATIVES

Class of relevant security	Product description e.g. call option	Written or purchased	Number of securities to which option or derivative relates	Exercise price per unit	Type e.g. American, European etc.	Expiry date
5p ordinary	Swap	Sold	114	0.0000	N/A	17/09/2015
5p ordinary	Swap	Sold	7,352	0.0000	N/A	17/09/2015
5p ordinary	Swap	Sold	13,652	0.0000	N/A	22/09/2015
5p ordinary	Swap	Sold	20,695	0.0000	N/A	17/09/2015
5p ordinary	Swap	Sold	24,316	0.0000	N/A	17/09/2015

3. AGREEMENTS TO PURCHASE OR SELL

Full details should be given so that the nature of the interest or position can be fully understood:

It is not necessary to provide details on a Supplement form (Open Positions) with regard to contracts for differences ("CFD") or spread bets

The currency of all pieces and other monetary amounts should be stated.

The Panel's Market Surveillance Unit is available for consultation in relation to the Code's dealing disclosure requirements on +44 (0)20 7638 0129.

This information is provided by RNS

The company news service from the London Stock Exchange

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	1st Jan change	Capi.
ELI LILLY AND COMPANY	+25.61%	660B
NOVO NORDISK A/S	+25.87%	562B
JOHNSON & JOHNSON	-5.24%	358B
MERCK & CO., INC.	+16.49%	322B
ABBVIE INC.	+8.28%	297B
ASTRAZENECA PLC	+7.09%	219B
ROCHE HOLDING AG	-9.12%	196B
NOVARTIS AG	+5.01%	199B
PFIZER, INC.	-8.75%	149B

Shire

Equities

JE00B2QKY057

Pharmaceuticals

Shire : Form 8.5 (EPT/NON-RI) - Amendment

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