Morgan Stanley & Co. LLC

AMENDMENT (Section 2(a))

FORM 8.5 (EPT/RI)

PUBLIC DEALING DISCLOSURE BY AN EXEMPT PRINCIPAL TRADER WITH RECOGNISED INTERMEDIARY STATUS DEALING IN A CLIENT-SERVING CAPACITY

Rule 8.5 of the Takeover Code (the "Code")

1. KEY INFORMATION

(a) Name of exempt principal trader:

Morgan Stanley & Co. LLC

(b) Name of offeror/offeree in relation to whose relevant securities this form relates:

Use a separate form for each offeror/offeree

AbbVie Inc

(c) Name of the party to the offer with which exempt principal trader is connected:

Shire Plc

(d) Date dealing undertaken:

14 OCTOBER 2014

(e) Has the EPT previously disclosed, or is it today disclosing, under the Code in respect of any other party to this offer?

Yes

2. DEALINGS BY THE EXEMPT PRINCIPAL TRADER

(a) Purchases and sales

Class of relevant security

Purchases/sales

Total number of securities

Highest price per unit paid/received

Lowest price per unit paid/received

Common shares of USD 0.01 par value

PURCHASES

27,500

33.9758 GBP

33.9758 GBP

Common shares of USD 0.01 par value

PURCHASES

1,768,552

54.8300 USD

53.0300 USD

Common shares of USD 0.01 par value

SALES

1,816,120

62.5000 USD

53.0200 USD

(b) Derivatives transactions (other than options)

Class of relevant security

Product description

e.g. CFD

Nature of dealing

e.g. opening/closing a long/short position, increasing/reducing a long/short position

Number of reference securities

Price per unit

N/A

N/A

N/A

N/A

N/A

(c) Options transactions in respect of existing securities

(i) Writing, selling, purchasing or varying

Class of relevant security

Product description e.g. call option

Writing, purchasing, selling, varying etc.

Number of securities to which option relates

Exercise price per unit

Type e.g. American, European etc.

Expiry date

Option money paid/ received per unit

Common shares of USD 0.01 par value

CALL

PURCHASE

600

57.5000

A

18/10/2014

0.0500 USD

Common shares of USD 0.01 par value

CALL

PURCHASE

200

57.5000

A

18/10/2014

0.0500 USD

Common shares of USD 0.01 par value

CALL

PURCHASE

6,800

57.5000

A

18/10/2014

0.0500 USD

Common shares of USD 0.01 par value

CALL

PURCHASE

200

62.5000

A

17/01/2015

0.4000 USD

Common shares of USD 0.01 par value

CALL

PURCHASE

100

55.0000

A

18/10/2014

0.5000 USD

Common shares of USD 0.01 par value

CALL

PURCHASE

100

55.0000

A

18/10/2014

0.5000 USD

Common shares of USD 0.01 par value

CALL

PURCHASE

3,000

62.5000

A

17/01/2015

0.5200 USD

Common shares of USD 0.01 par value

CALL

PURCHASE

400

54.0000

A

18/10/2014

0.5900 USD

Common shares of USD 0.01 par value

CALL

PURCHASE

100

54.0000

A

18/10/2014

0.7000 USD

Common shares of USD 0.01 par value

CALL

PURCHASE

500

54.0000

A

18/10/2014

0.8000 USD

Common shares of USD 0.01 par value

CALL

PURCHASE

100

60.0000

A

17/01/2015

0.9000 USD

Common shares of USD 0.01 par value

CALL

PURCHASE

100

60.0000

A

17/01/2015

0.9000 USD

Common shares of USD 0.01 par value

CALL

PURCHASE

1,600

57.5000

A

22/11/2014

0.9500 USD

Common shares of USD 0.01 par value

CALL

PURCHASE

100

57.5000

A

22/11/2014

0.9800 USD

Common shares of USD 0.01 par value

CALL

PURCHASE

100

60.0000

A

17/01/2015

1.0000 USD

Common shares of USD 0.01 par value

CALL

PURCHASE

1,500

54.5000

A

24/10/2014

1.0000 USD

Common shares of USD 0.01 par value

CALL

PURCHASE

100

56.0000

A

07/11/2014

1.0200 USD

Common shares of USD 0.01 par value

PUT

PURCHASE

900

52.5000

A

22/11/2014

1.2200 USD

Common shares of USD 0.01 par value

PUT

PURCHASE

1,200

52.5000

A

22/11/2014

1.2200 USD

Common shares of USD 0.01 par value

PUT

PURCHASE

300

52.5000

A

22/11/2014

1.2300 USD

Common shares of USD 0.01 par value

PUT

PURCHASE

1,000

55.0000

A

18/10/2014

1.3000 USD

Common shares of USD 0.01 par value

CALL

PURCHASE

100

60.0000

A

20/02/2015

1.3200 USD

Common shares of USD 0.01 par value

CALL

PURCHASE

400

60.0000

A

15/05/2015

2.1200 USD

Common shares of USD 0.01 par value

PUT

PURCHASE

2,800

50.0000

A

20/02/2015

2.1500 USD

Common shares of USD 0.01 par value

PUT

PURCHASE

1,500

50.0000

A

20/02/2015

2.2000 USD

Common shares of USD 0.01 par value

PUT

PURCHASE

400

50.0000

A

20/02/2015

2.2000 USD

Common shares of USD 0.01 par value

PUT

PURCHASE

1,100

50.0000

A

20/02/2015

2.2000 USD

Common shares of USD 0.01 par value

PUT

PURCHASE

600

47.5000

A

15/05/2015

2.2500 USD

Common shares of USD 0.01 par value

PUT

PURCHASE

900

52.5000

A

17/01/2015

2.3000 USD

Common shares of USD 0.01 par value

CALL

PURCHASE

3,200

65.0000

A

15/01/2016

2.4000 USD

Common shares of USD 0.01 par value

PUT

PURCHASE

700

55.0000

A

22/11/2014

2.4000 USD

Common shares of USD 0.01 par value

PUT

PURCHASE

3,900

55.0000

A

22/11/2014

2.5200 USD

Common shares of USD 0.01 par value

PUT

PURCHASE

500

55.0000

A

22/11/2014

2.8300 USD

Common shares of USD 0.01 par value

CALL

PURCHASE

400

52.5000

A

22/11/2014

3.0000 USD

Common shares of USD 0.01 par value

CALL

PURCHASE

1,000

52.5000

A

22/11/2014

3.0000 USD

Common shares of USD 0.01 par value

CALL

PURCHASE

600

52.5000

A

22/11/2014

3.0000 USD

Common shares of USD 0.01 par value

CALL

PURCHASE

200

52.5000

A

22/11/2014

3.0000 USD

Common shares of USD 0.01 par value

CALL

PURCHASE

100

52.5000

A

22/11/2014

3.0000 USD

Common shares of USD 0.01 par value

CALL

PURCHASE

1,900

52.5000

A

22/11/2014

3.0000 USD

Common shares of USD 0.01 par value

CALL

PURCHASE

400

52.5000

A

22/11/2014

3.0000 USD

Common shares of USD 0.01 par value

CALL

PURCHASE

500

52.5000

A

22/11/2014

3.0000 USD

Common shares of USD 0.01 par value

PUT

PURCHASE

1,100

57.5000

A

22/11/2014

4.0000 USD

Common shares of USD 0.01 par value

PUT

PURCHASE

500

42.5000

A

20/01/2017

5.0000 USD

Common shares of USD 0.01 par value

PUT

PURCHASE

1,000

57.5000

A

17/01/2015

5.3000 USD

Common shares of USD 0.01 par value

CALL

PURCHASE

200

50.0000

A

17/01/2015

5.8400 USD

Common shares of USD 0.01 par value

CALL

SALE

100

62.5000

A

18/10/2014

0.0500 USD

Common shares of USD 0.01 par value

CALL

SALE

400

57.5000

A

18/10/2014

0.0800 USD

Common shares of USD 0.01 par value

CALL

SALE

4,000

55.0000

A

18/10/2014

0.6000 USD

Common shares of USD 0.01 par value

CALL

SALE

500

55.0000

A

18/10/2014

0.6000 USD

Common shares of USD 0.01 par value

CALL

SALE

3,100

55.0000

A

18/10/2014

0.6000 USD

Common shares of USD 0.01 par value

CALL

SALE

5,100

55.0000

A

18/10/2014

0.6000 USD

Common shares of USD 0.01 par value

CALL

SALE

300

57.5000

A

22/11/2014

0.9900 USD

Common shares of USD 0.01 par value

PUT

SALE

1,200

52.5000

A

22/11/2014

1.2900 USD

Common shares of USD 0.01 par value

PUT

SALE

200

52.5000

A

22/11/2014

1.3200 USD

Common shares of USD 0.01 par value

PUT

SALE

100

52.5000

A

22/11/2014

1.3300 USD

Common shares of USD 0.01 par value

PUT

SALE

500

55.0000

A

18/10/2014

1.6100 USD

Common shares of USD 0.01 par value

PUT

SALE

500

52.5000

A

22/11/2014

1.6500 USD

Common shares of USD 0.01 par value

CALL

SALE

100

57.5000

A

17/01/2015

1.7000 USD

Common shares of USD 0.01 par value

CALL

SALE

3,800

57.5000

A

17/01/2015

1.7000 USD

Common shares of USD 0.01 par value

CALL

SALE

1,100

55.0000

A

22/11/2014

1.7500 USD

Common shares of USD 0.01 par value

CALL

SALE

400

55.0000

A

14/11/2014

1.7500 USD

Common shares of USD 0.01 par value

PUT

SALE

500

54.0000

A

31/10/2014

1.7500 USD

Common shares of USD 0.01 par value

PUT

SALE

500

54.0000

A

31/10/2014

1.7500 USD

Common shares of USD 0.01 par value

CALL

SALE

1,600

55.0000

A

22/11/2014

1.8000 USD

Common shares of USD 0.01 par value

PUT

SALE

100

50.0000

A

17/01/2015

2.0500 USD

Common shares of USD 0.01 par value

CALL

SALE

1,600

57.5000

A

20/02/2015

2.2000 USD

Common shares of USD 0.01 par value

PUT

SALE

100

55.0000

A

22/11/2014

2.3700 USD

Common shares of USD 0.01 par value

CALL

SALE

3,000

55.0000

A

17/01/2015

2.5300 USD

Common shares of USD 0.01 par value

CALL

SALE

100

55.0000

A

17/01/2015

2.7000 USD

Common shares of USD 0.01 par value

CALL

SALE

100

55.0000

A

17/01/2015

2.7000 USD

Common shares of USD 0.01 par value

CALL

SALE

1,000

55.0000

A

17/01/2015

2.7000 USD

Common shares of USD 0.01 par value

CALL

SALE

100

55.0000

A

17/01/2015

2.9500 USD

Common shares of USD 0.01 par value

CALL

SALE

8,600

62.5000

A

15/01/2016

3.3200 USD

Common shares of USD 0.01 par value

CALL

SALE

7,600

62.5000

A

15/01/2016

3.3800 USD

Common shares of USD 0.01 par value

CALL

SALE

100

60.0000

A

15/01/2016

4.4000 USD

Common shares of USD 0.01 par value

CALL

SALE

100

50.0000

A

15/05/2015

6.9600 USD

(ii) Exercising

Class of relevant security

Product description e.g. call option

Number of securities

Exercise price per unit

Common shares of USD 0.01 par value

PUT

3,000

62.5000 USD

(d) Other dealings (including subscribing for new securities)

Class of relevant security

Nature of dealing e.g. subscription, conversion

Details

Price per unit (if applicable)

N/A

N/A

N/A

N/A

The currency of all prices and other monetary amounts should be stated.

Where there have been dealings in more than one class of relevant securities of the offeror or offeree named in 1(b), copy table 2(a), (b), (c) or (d) (as appropriate) for each additional class of relevant security dealt in.

3. OTHER INFORMATION

(a) Indemnity and other dealing arrangements

Details of any indemnity or option arrangement, or any agreement or understanding, formal or informal, relating to relevant securities which may be an inducement to deal or refrain from dealing entered into by the exempt principal trader making the disclosure and any party to the offer or any person acting in concert with a party to the offer:

If there are no such agreements, arrangements or understandings, state "none"

None

(b) Agreements, arrangements or understandings relating to options or derivatives

Details of any agreement, arrangement or understanding, formal or informal, between the exempt principal trader making the disclosure and any other person relating to:

(i) the voting rights of any relevant securities under any option; or

(ii) the voting rights or future acquisition or disposal of any relevant securities to which any derivative is referenced:

If there are no such agreements, arrangements or understandings, state "none"

None

Date of disclosure:

17 OCTOBER 2014

Contact name:

Darren Wickert

Telephone number:

+44 (0)20 7425 6578

Public disclosures under Rule 8 of the Code must be made to a Regulatory Information Service and must also be emailed to the Takeover Panel atmonitoring@disclosure.org.uk. The Panel's Market Surveillance Unit is available for consultation in relation to the Code's dealing disclosure requirements on +44 (0)20 7638 0129.

The Code can be viewed on the Panel's website atwww.thetakeoverpanel.org.uk.


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