Morgan Stanley Capital Services LLC

AMENDMENT (Section 2(b))

FORM 8.5 (EPT/RI)

PUBLIC DEALING DISCLOSURE BY AN EXEMPT PRINCIPAL TRADER WITH RECOGNISED INTERMEDIARY STATUS DEALING IN A CLIENT-SERVING CAPACITY

Rule 8.5 of the Takeover Code (the "Code")

1. KEY INFORMATION

(a) Name of exempt principal trader:

Morgan Stanley Capital Services LLC

(b) Name of offeror/offeree in relation to whose relevant securities this form relates:

Use a separate form for each offeror/offeree

Shire Plc

(c) Name of the party to the offer with which exempt principal trader is connected:

Shire Plc

(d) Date dealing undertaken:

15 OCTOBER 2014

(e) Has the EPT previously disclosed, or is it today disclosing, under the Code in respect of any other party to this offer?

Yes

2. DEALINGS BY THE EXEMPT PRINCIPAL TRADER

(a) Purchases and sales

Class of relevant security

Purchases/sales

Total number of securities

Highest price per unit paid/received

Lowest price per unit paid/received

ADS

PURCHASES

3,490

191.8800 USD

159.0400 USD

ADS

SALES

9,235

190.5000 USD

164.8300 USD

(b) Derivatives transactions (other than options)

Class of relevant security

Product description

e.g. CFD

Nature of dealing

e.g. opening/closing a long/short position, increasing/reducing a long/short position

Number of reference securities

Price per unit

5p ordinary

CFD

LONG

5,725

37.0625 GBP

5p ordinary

CFD

LONG

7,629

37.0625 GBP

5p ordinary

CFD

LONG

33,072

37.0625 GBP

5p ordinary

CFD

LONG

100,696

37.0625 GBP

5p ordinary

CFD

LONG

60,929

37.0625 GBP

5p ordinary

CFD

LONG

11,381

37.0625 GBP

5p ordinary

CFD

LONG

7,619

37.0625 GBP

5p ordinary

CFD

LONG

31,661

37.0625 GBP

5p ordinary

CFD

LONG

5,982

37.0625 GBP

5p ordinary

CFD

LONG

142,960

37.0625 GBP

5p ordinary

CFD

LONG

50,187

37.0625 GBP

5p ordinary

CFD

LONG

209,137

37.0625 GBP

5p ordinary

CFD

LONG

2,584

37.0625 GBP

5p ordinary

CFD

LONG

626

37.0625 GBP

5p ordinary

CFD

LONG

10,990

37.0625 GBP

5p ordinary

CFD

LONG

7,976

37.0625 GBP

5p ordinary

CFD

LONG

1,762

37.0625 GBP

5p ordinary

CFD

LONG

9,981

37.0625 GBP

5p ordinary

CFD

LONG

550

37.4513 GBP

5p ordinary

CFD

LONG

100,000

37.4625 GBP

5p ordinary

CFD

LONG

2,299

37.5749 GBP

5p ordinary

CFD

LONG

15,479

37.8372 GBP

5p ordinary

CFD

LONG

3,640

37.8372 GBP

5p ordinary

CFD

LONG

11,233

37.8372 GBP

5p ordinary

CFD

LONG

2,481

37.8372 GBP

5p ordinary

CFD

LONG

294,560

37.8372 GBP

5p ordinary

CFD

LONG

16,030

37.8372 GBP

5p ordinary

CFD

LONG

881

37.8372 GBP

5p ordinary

CFD

LONG

70,686

37.8372 GBP

5p ordinary

CFD

LONG

201,352

37.8372 GBP

5p ordinary

CFD

LONG

8,426

37.8372 GBP

5p ordinary

CFD

LONG

10,730

37.8372 GBP

5p ordinary

CFD

LONG

44,594

37.8372 GBP

5p ordinary

CFD

LONG

85,815

37.8372 GBP

5p ordinary

CFD

LONG

141,826

37.8372 GBP

5p ordinary

CFD

LONG

46,580

37.8372 GBP

5p ordinary

CFD

LONG

10,744

37.8372 GBP

5p ordinary

CFD

LONG

8,064

37.8372 GBP

5p ordinary

CFD

LONG

14,058

37.8372 GBP

5p ordinary

CFD

LONG

6,007

37.9135 GBP

5p ordinary

CFD

LONG

66,864

37.9135 GBP

5p ordinary

CFD

LONG

12,138

37.9135 GBP

5p ordinary

CFD

LONG

350,000

37.9853 GBP

5p ordinary

CFD

LONG

8,471

38.6837 GBP

5p ordinary

CFD

LONG

900

38.6837 GBP

5p ordinary

CFD

LONG

6,800

38.6837 GBP

5p ordinary

CFD

LONG

6,300

38.7053 GBP

5p ordinary

CFD

LONG

4,526

38.8733 GBP

5p ordinary

CFD

LONG

6,032

38.8733 GBP

5p ordinary

CFD

LONG

48,178

38.8733 GBP

5p ordinary

CFD

LONG

26,151

38.8733 GBP

5p ordinary

CFD

LONG

79,623

38.8733 GBP

5p ordinary

CFD

LONG

9,000

38.8733 GBP

5p ordinary

CFD

LONG

25,036

38.8733 GBP

5p ordinary

CFD

LONG

6,024

38.8733 GBP

5p ordinary

CFD

LONG

4,730

38.8733 GBP

5p ordinary

CFD

LONG

113,041

38.8733 GBP

5p ordinary

CFD

LONG

39,684

38.8733 GBP

5p ordinary

CFD

LONG

6,307

38.8733 GBP

5p ordinary

CFD

LONG

1,393

38.8733 GBP

5p ordinary

CFD

LONG

2,043

38.8733 GBP

5p ordinary

CFD

LONG

8,690

38.8733 GBP

5p ordinary

CFD

LONG

495

38.8733 GBP

5p ordinary

CFD

LONG

165,370

38.8733 GBP

5p ordinary

CFD

LONG

7,892

38.8733 GBP

5p ordinary

CFD

LONG

300,000

38.8941 GBP

5p ordinary

CFD

LONG

8,336

38.9414 GBP

5p ordinary

CFD

LONG

6,843

38.9414 GBP

5p ordinary

CFD

LONG

908

38.9414 GBP

5p ordinary

CFD

LONG

100

39.0571 GBP

5p ordinary

CFD

LONG

600

39.0571 GBP

5p ordinary

CFD

LONG

828

39.0571 GBP

5p ordinary

CFD

LONG

8,300

39.0637 GBP

5p ordinary

CFD

LONG

6,800

39.0637 GBP

5p ordinary

CFD

LONG

1,000

39.0637 GBP

5p ordinary

CFD

LONG

2,686

39.5706 GBP

5p ordinary

CFD

LONG

2,016

39.5706 GBP

5p ordinary

CFD

LONG

21,454

39.5706 GBP

5p ordinary

CFD

LONG

35,457

39.5706 GBP

5p ordinary

CFD

LONG

11,645

39.5706 GBP

5p ordinary

CFD

LONG

4,008

39.5706 GBP

5p ordinary

CFD

LONG

17,671

39.5706 GBP

5p ordinary

CFD

LONG

50,338

39.5706 GBP

5p ordinary

CFD

LONG

2,683

39.5706 GBP

5p ordinary

CFD

LONG

2,106

39.5706 GBP

5p ordinary

CFD

LONG

11,148

39.5706 GBP

5p ordinary

CFD

LONG

73,640

39.5706 GBP

5p ordinary

CFD

LONG

220

39.5706 GBP

5p ordinary

CFD

LONG

3,871

39.5706 GBP

5p ordinary

CFD

LONG

910

39.5706 GBP

5p ordinary

CFD

LONG

620

39.5706 GBP

5p ordinary

CFD

LONG

2,808

39.5706 GBP

5p ordinary

CFD

LONG

3,514

39.5706 GBP

5p ordinary

CFD

LONG

154,201

39.6454 GBP

5p ordinary

CFD

LONG

148,985

39.6454 GBP

5p ordinary

CFD

LONG

15,151

39.6454 GBP

5p ordinary

CFD

LONG

81,663

39.6454 GBP

5p ordinary

CFD

LONG

34,642

39.7602 GBP

5p ordinary

CFD

LONG

11,378

39.7602 GBP

5p ordinary

CFD

LONG

20,961

39.7602 GBP

5p ordinary

CFD

LONG

1,970

39.7602 GBP

5p ordinary

CFD

LONG

2,624

39.7602 GBP

5p ordinary

CFD

LONG

2,744

39.7602 GBP

5p ordinary

CFD

LONG

606

39.7602 GBP

5p ordinary

CFD

LONG

889

39.7602 GBP

5p ordinary

CFD

LONG

3,781

39.7602 GBP

5p ordinary

CFD

LONG

215

39.7602 GBP

5p ordinary

CFD

LONG

71,948

39.7602 GBP

5p ordinary

CFD

LONG

10,892

39.7602 GBP

5p ordinary

CFD

LONG

2,621

39.7602 GBP

5p ordinary

CFD

LONG

2,059

39.7602 GBP

5p ordinary

CFD

LONG

49,182

39.7602 GBP

5p ordinary

CFD

LONG

17,265

39.7602 GBP

5p ordinary

CFD

LONG

3,915

39.7602 GBP

5p ordinary

CFD

LONG

3,434

39.7602 GBP

5p ordinary

CFD

SHORT

7,700

36.6747 GBP

5p ordinary

CFD

SHORT

900

36.6747 GBP

5p ordinary

CFD

SHORT

8,400

36.6747 GBP

5p ordinary

CFD

SHORT

382

37.1042 GBP

5p ordinary

CFD

SHORT

12,279

37.1042 GBP

5p ordinary

CFD

SHORT

1,010

37.1042 GBP

5p ordinary

CFD

SHORT

1,339

37.1042 GBP

5p ordinary

CFD

SHORT

2,400

37.4717 GBP

5p ordinary

CFD

SHORT

2,300

37.4717 GBP

5p ordinary

CFD

SHORT

300

37.4717 GBP

5p ordinary

CFD

SHORT

300

37.5302 GBP

5p ordinary

CFD

SHORT

2,100

37.5302 GBP

5p ordinary

CFD

SHORT

2,300

37.5302 GBP

5p ordinary

CFD

SHORT

16,900

37.5302 GBP

5p ordinary

CFD

SHORT

18,550

37.5302 GBP

5p ordinary

CFD

SHORT

2,400

37.5302 GBP

5p ordinary

CFD

SHORT

2,400

37.6139 GBP

5p ordinary

CFD

SHORT

300

37.6139 GBP

5p ordinary

CFD

SHORT

2,300

37.6139 GBP

5p ordinary

CFD

SHORT

692

37.6364 GBP

5p ordinary

CFD

SHORT

18,653

37.6364 GBP

5p ordinary

CFD

SHORT

5,092

37.6364 GBP

5p ordinary

CFD

SHORT

754

37.6364 GBP

5p ordinary

CFD

SHORT

25,306

37.6364 GBP

5p ordinary

CFD

SHORT

793

37.6364 GBP

5p ordinary

CFD

SHORT

1,984

37.6364 GBP

5p ordinary

CFD

SHORT

1,358

37.7627 GBP

5p ordinary

CFD

SHORT

739

37.7627 GBP

5p ordinary

CFD

SHORT

17,963

37.7627 GBP

5p ordinary

CFD

SHORT

544

37.7627 GBP

5p ordinary

CFD

SHORT

4,850

37.7627 GBP

5p ordinary

CFD

SHORT

12,332

37.7627 GBP

5p ordinary

CFD

SHORT

540

37.7627 GBP

5p ordinary

CFD

SHORT

2,300

37.8057 GBP

5p ordinary

CFD

SHORT

300

37.8057 GBP

5p ordinary

CFD

SHORT

2,400

37.8057 GBP

5p ordinary

CFD

SHORT

987

37.8555 GBP

5p ordinary

CFD

SHORT

107,013

38.0673 GBP

5p ordinary

CFD

SHORT

4,900

38.2796 GBP

5p ordinary

CFD

SHORT

600

38.2796 GBP

5p ordinary

CFD

SHORT

4,500

38.2796 GBP

5p ordinary

CFD

SHORT

4,900

38.3206 GBP

5p ordinary

CFD

SHORT

4,500

38.3206 GBP

5p ordinary

CFD

SHORT

600

38.3206 GBP

5p ordinary

CFD

SHORT

2,673

38.4174 GBP

5p ordinary

CFD

SHORT

920

38.4734 GBP

5p ordinary

CFD

SHORT

300

38.5165 GBP

5p ordinary

CFD

SHORT

2,400

38.5165 GBP

5p ordinary

CFD

SHORT

2,300

38.5165 GBP

5p ordinary

CFD

SHORT

2,796

38.6314 GBP

5p ordinary

CFD

SHORT

114,188

38.6314 GBP

5p ordinary

CFD

SHORT

2,796

38.6314 GBP

5p ordinary

CFD

SHORT

300

38.7100 GBP

5p ordinary

CFD

SHORT

3,104

38.7100 GBP

5p ordinary

CFD

SHORT

2,800

38.7100 GBP

5p ordinary

CFD

SHORT

7,400

38.8217 GBP

5p ordinary

CFD

SHORT

800

38.8217 GBP

5p ordinary

CFD

SHORT

6,800

38.8217 GBP

5p ordinary

CFD

SHORT

16,057

39.0121 GBP

5p ordinary

CFD

SHORT

2,602

39.1417 GBP

5p ordinary

CFD

SHORT

800

39.2247 GBP

5p ordinary

CFD

SHORT

17,621

39.2922 GBP

5p ordinary

CFD

SHORT

61,200

39.3805 GBP

5p ordinary

CFD

SHORT

220

39.4386 GBP

5p ordinary

CFD

SHORT

20,397

39.4386 GBP

5p ordinary

CFD

SHORT

220

39.4386 GBP

5p ordinary

CFD

SHORT

800

39.5727 GBP

5p ordinary

CFD

SHORT

7,400

39.5727 GBP

5p ordinary

CFD

SHORT

6,800

39.5727 GBP

5p ordinary

CFD

SHORT

141,864

39.7883 GBP

5p ordinary

CFD

SHORT

10,083

39.7883 GBP

5p ordinary

CFD

SHORT

4,907

39.7883 GBP

5p ordinary

CFD

SHORT

16

39.8006 GBP

5p ordinary

CFD

SHORT

293

39.8023 GBP

5p ordinary

CFD

SHORT

179

39.8026 GBP

5p ordinary

CFD

SHORT

14,208

39.9983 GBP

5p ordinary

CFD

SHORT

627

39.9983 GBP

5p ordinary

CFD

SHORT

20,697

39.9983 GBP

5p ordinary

CFD

SHORT

5,588

39.9983 GBP

5p ordinary

CFD

SHORT

852

39.9983 GBP

5p ordinary

CFD

SHORT

623

39.9983 GBP

5p ordinary

CFD

SHORT

1,564

39.9983 GBP

5p ordinary

CFD

SHORT

39,000

40.0178 GBP

5p ordinary

CFD

SHORT

4,200

40.0628 GBP

5p ordinary

CFD

SHORT

6,870

40.0628 GBP

5p ordinary

CFD

SHORT

382

40.0629 GBP

5p ordinary

CFD

SHORT

1,300

40.0629 GBP

5p ordinary

CFD

SHORT

390,000

40.2469 GBP

5p ordinary

CFD

SHORT

21,306

37.9500 GBP

5p ordinary

CFD

SHORT

2,268

37.9500 GBP

5p ordinary

CFD

SHORT

24,447

37.9500 GBP

5p ordinary

CFD

SHORT

882

37.9500 GBP

5p ordinary

CFD

SHORT

1,097

37.9500 GBP

ADS

CFD

LONG

8,000

177.5711 USD

ADS

CFD

LONG

24

165.7400 USD

ADS

CFD

LONG

650

174.7623 USD

ADS

CFD

LONG

8,000

177.6011 USD

ADS

CFD

LONG

1

188.3100 USD

ADS

CFD

LONG

10

188.3100 USD

ADS

CFD

SHORT

800

165.9075 USD

ADS

CFD

SHORT

70

165.9437 USD

ADS

CFD

SHORT

200

179.8200 USD

(c) Options transactions in respect of existing securities

(i) Writing, selling, purchasing or varying

Class of relevant security

Product description e.g. call option

Writing, purchasing, selling, varying etc.

Number of securities to which option relates

Exercise price per unit

Type e.g. American, European etc.

Expiry date

Option money paid/ received per unit

N/A

N/A

N/A

N/A

N/A

N/A

N/A

N/A

(ii) Exercising

Class of relevant security

Product description e.g. call option

Number of securities

Exercise price per unit

N/A

N/A

N/A

N/A

(d) Other dealings (including subscribing for new securities)

Class of relevant security

Nature of dealing e.g. subscription, conversion

Details

Price per unit (if applicable)

N/A

N/A

N/A

N/A

The currency of all prices and other monetary amounts should be stated.

Where there have been dealings in more than one class of relevant securities of the offeror or offeree named in 1(b), copy table 2(a), (b), (c) or (d) (as appropriate) for each additional class of relevant security dealt in.

3. OTHER INFORMATION

(a) Indemnity and other dealing arrangements

Details of any indemnity or option arrangement, or any agreement or understanding, formal or informal, relating to relevant securities which may be an inducement to deal or refrain from dealing entered into by the exempt principal trader making the disclosure and any party to the offer or any person acting in concert with a party to the offer:

If there are no such agreements, arrangements or understandings, state "none"

None

(b) Agreements, arrangements or understandings relating to options or derivatives

Details of any agreement, arrangement or understanding, formal or informal, between the exempt principal trader making the disclosure and any other person relating to:

(i) the voting rights of any relevant securities under any option; or

(ii) the voting rights or future acquisition or disposal of any relevant securities to which any derivative is referenced:

If there are no such agreements, arrangements or understandings, state "none"

None

Date of disclosure:

20 OCTOBER 2014

Contact name:

Darren Wickert

Telephone number:

+44 (0)20 7425 6578

Public disclosures under Rule 8 of the Code must be made to a Regulatory Information Service and must also be emailed to the Takeover Panel atmonitoring@disclosure.org.uk. The Panel's Market Surveillance Unit is available for consultation in relation to the Code's dealing disclosure requirements on +44 (0)20 7638 0129.

The Code can be viewed on the Panel's website atwww.thetakeoverpanel.org.uk.


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