Morgan Stanley & Co. LLC



AMENDMENT ( Section 2(a))

FORM 8.5 (EPT/RI)

PUBLIC DEALING DISCLOSURE BY AN EXEMPT PRINCIPAL TRADER WITH RECOGNISED INTERMEDIARY STATUS DEALING IN A CLIENT-SERVING CAPACITY

Rule 8.5 of the Takeover Code (the "Code")

1. KEY INFORMATION

(a) Name of exempt principal trader:

Morgan Stanley & Co. LLC

(b) Name of offeror/offeree in relation to whose relevant securities this form relates:

Use a separate form for each offeror/offeree

SHIRE PLC

(c) Name of the party to the offer with which exempt principal trader is connected:

SHIRE PLC

(d) Date dealing undertaken:

15 JULY 2014

(e) Has the EPT previously disclosed, or is it today disclosing, under the Code in respect of any other party to this offer?

Yes

2. DEALINGS BY THE EXEMPT PRINCIPAL TRADER

(a) Purchases and sales

Class of relevant security

Purchases/sales

Total number of securities

Highest price per unit paid/received

Lowest price per unit paid/received

COMMON STOCK

PURCHASES

2,078,672

49.3019 GBP

48.6456 GBP

COMMON STOCK

SALES

2,078,672

49.3018 GBP

48.6456 GBP

ADS

PURCHASES

742,691

252.7600 USD

249.0500 USD

ADS

SALES

740,500

252.7600 USD

249.0500 USD

(b) Derivatives transactions (other than options)

Class of relevant security

Product description

e.g. CFD

Nature of dealing

e.g. opening/closing a long/short position, increasing/reducing a long/short position

Number of reference securities

Price per unit

N/A

N/A

N/A

N/A

N/A

(c) Options transactions in respect of existing securities

(i) Writing, selling, purchasing or varying

Class of relevant security

Product description e.g. call option

Writing, purchasing, selling, varying etc.

Number of securities to which option relates

Exercise price per unit

Type e.g. American, European etc.

Expiry date

Option money paid/ received per unit

ADS

PUT

PURCHASE

700

220.0000

A

19/07/2014

0.8500 USD

ADS

PUT

PURCHASE

1100

220.0000

A

19/07/2014

0.9000 USD

ADS

PUT

PURCHASE

1200

225.0000

A

19/07/2014

1.1000 USD

ADS

CALL

PURCHASE

100

260.0000

A

19/07/2014

1.5400 USD

ADS

PUT

PURCHASE

500

200.0000

A

16/08/2014

1.6000 USD

ADS

PUT

PURCHASE

1000

235.0000

A

19/07/2014

2.1000 USD

ADS

PUT

PURCHASE

200

235.0000

A

19/07/2014

2.2000 USD

ADS

CALL

PURCHASE

100

265.0000

A

16/08/2014

2.2100 USD

ADS

PUT

PURCHASE

1000

240.0000

A

19/07/2014

3.1100 USD

ADS

CALL

PURCHASE

1000

260.0000

A

16/08/2014

3.7000 USD

ADS

CALL

SALE

100

280.0000

A

19/07/2014

0.4500 USD

ADS

PUT

SALE

2400

230.0000

A

19/07/2014

0.8500 USD

ADS

PUT

SALE

1900

230.0000

A

19/07/2014

0.8500 USD

ADS

PUT

SALE

1900

230.0000

A

19/07/2014

0.8500 USD

ADS

CALL

SALE

1100

260.0000

A

19/07/2014

1.2000 USD

ADS

CALL

SALE

1100

260.0000

A

19/07/2014

1.2000 USD

ADS

PUT

SALE

500

205.0000

A

16/08/2014

1.8000 USD

ADS

PUT

SALE

400

235.0000

A

19/07/2014

2.0500 USD

ADS

PUT

SALE

100

220.0000

A

16/08/2014

2.3000 USD

ADS

PUT

SALE

500

220.0000

A

16/08/2014

2.3000 USD

ADS

PUT

SALE

1000

220.0000

A

16/08/2014

2.4000 USD

ADS

PUT

SALE

1000

220.0000

A

16/08/2014

2.4000 USD

ADS

PUT

SALE

1000

220.0000

A

16/08/2014

2.4000 USD

ADS

PUT

SALE

1000

230.0000

A

16/08/2014

2.9000 USD

ADS

PUT

SALE

300

230.0000

A

16/08/2014

3.1000 USD

ADS

PUT

SALE

100

230.0000

A

16/08/2014

3.2000 USD

ADS

PUT

SALE

300

230.0000

A

16/08/2014

3.2000 USD

ADS

PUT

SALE

1000

230.0000

A

16/08/2014

3.2000 USD

ADS

PUT

SALE

1000

245.0000

A

19/07/2014

3.2000 USD

ADS

PUT

SALE

1100

250.0000

A

19/07/2014

3.5000 USD

ADS

PUT

SALE

2500

245.0000

A

19/07/2014

3.7000 USD

ADS

CALL

SALE

300

260.0000

A

16/08/2014

4.2000 USD

ADS

PUT

SALE

1000

245.0000

A

19/07/2014

4.2900 USD

ADS

CALL

SALE

1000

260.0000

A

16/08/2014

4.3000 USD

ADS

PUT

SALE

1000

245.0000

A

19/07/2014

4.4000 USD

ADS

CALL

SALE

300

250.0000

A

19/07/2014

5.6000 USD

ADS

CALL

SALE

100

255.0000

A

16/08/2014

6.3000 USD

ADS

PUT

SALE

2800

245.0000

A

16/08/2014

6.3000 USD

ADS

PUT

SALE

300

245.0000

A

16/08/2014

6.3000 USD

(ii) Exercising

Class of relevant security

Product description e.g. call option

Number of securities

Exercise price per unit

N/A

N/A

N/A

N/A

(d) Other dealings (including subscribing for new securities)

Class of relevant security

Nature of dealing e.g. subscription, conversion

Details

Price per unit (if applicable)

N/A

N/A

N/A

N/A

The currency of all prices and other monetary amounts should be stated.

Where there have been dealings in more than one class of relevant securities of the offeror or offeree named in 1(b), copy table 2(a), (b), (c) or (d) (as appropriate) for each additional class of relevant security dealt in.

3. OTHER INFORMATION

(a) Indemnity and other dealing arrangements

Details of any indemnity or option arrangement, or any agreement or understanding, formal or informal, relating to relevant securities which may be an inducement to deal or refrain from dealing entered into by the exempt principal trader making the disclosure and any party to the offer or any person acting in concert with a party to the offer:

If there are no such agreements, arrangements or understandings, state "none"

None

(b) Agreements, arrangements or understandings relating to options or derivatives

Details of any agreement, arrangement or understanding, formal or informal, between the exempt principal trader making the disclosure and any other person relating to:

(i) the voting rights of any relevant securities under any option; or

(ii) the voting rights or future acquisition or disposal of any relevant securities to which any derivative is referenced:

If there are no such agreements, arrangements or understandings, state "none"

None

Date of disclosure:

21 JULY 2014

Contact name:

Darren Wickert

Telephone number:

+44 (0)20 7425 6578

Public disclosures under Rule 8 of the Code must be made to a Regulatory Information Service and must also be emailed to the Takeover Panel atmonitoring@disclosure.org.uk. The Panel's Market Surveillance Unit is available for consultation in relation to the Code's dealing disclosure requirements on +44 (0)20 7638 0129.

The Code can be viewed on the Panel's website atwww.thetakeoverpanel.org.uk.


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