Morgan Stanley Securities Limited



AMENDMENT (Section 2(a) & 2(b))

FORM 8.5 (EPT/RI)

PUBLIC DEALING DISCLOSURE BY AN EXEMPT PRINCIPAL TRADER WITH RECOGNISED INTERMEDIARY STATUS DEALING IN A CLIENT-SERVING CAPACITY

Rule 8.5 of the Takeover Code (the "Code")

1. KEY INFORMATION

(a) Name of exempt principal trader:

Morgan Stanley Securities Limited

(b) Name of offeror/offeree in relation to whose relevant securities this form relates:

Use a separate form for each offeror/offeree

SHIRE PLC

(c) Name of the party to the offer with which exempt principal trader is connected:

SHIRE PLC

(d) Date dealing undertaken:

23 JULY 2014

(e) Has the EPT previously disclosed, or is it today disclosing, under the Code in respect of any other party to this offer?

Yes

2. DEALINGS BY THE EXEMPT PRINCIPAL TRADER

(a) Purchases and sales

Class of relevant security

Purchases/sales

Total number of securities

Highest price per unit paid/received

Lowest price per unit paid/received

COMMON STOCK

PURCHASES

1,793,899

50.1000 GBP

49.2500 GBP

COMMON STOCK

SALES

1,758,057

50.1000 GBP

49.2500 GBP

COMMON STOCK

PURCHASES

31,049

84.9352 USD

84.9352 USD

(b) Derivatives transactions (other than options)

Class of relevant security

Product description

e.g. CFD

Nature of dealing

e.g. opening/closing a long/short position, increasing/reducing a long/short position

Number of reference securities

Price per unit

COMMON STOCK

CFD

LONG

564

49.5500 GBP

COMMON STOCK

CFD

LONG

19,645

49.5903 GBP

COMMON STOCK

CFD

LONG

1,239

49.7309 GBP

COMMON STOCK

CFD

LONG

7,753

49.7700 GBP

COMMON STOCK

CFD

LONG

4,687

49.7700 GBP

COMMON STOCK

CFD

LONG

6,296

49.7700 GBP

COMMON STOCK

CFD

LONG

425

49.7700 GBP

COMMON STOCK

CFD

LONG

1,055

49.7783 GBP

COMMON STOCK

CFD

LONG

411,369

49.8506 GBP

COMMON STOCK

CFD

LONG

3,176

49.8506 GBP

COMMON STOCK

CFD

LONG

105

49.8855 GBP

COMMON STOCK

CFD

LONG

370

49.9309 GBP

COMMON STOCK

CFD

LONG

74

49.9309 GBP

COMMON STOCK

CFD

LONG

1,433

49.9309 GBP

COMMON STOCK

CFD

LONG

42,639

49.9600 GBP

COMMON STOCK

CFD

LONG

64,517

49.9600 GBP

COMMON STOCK

CFD

LONG

6,780

49.9750 GBP

COMMON STOCK

CFD

SHORT

460

49.5781 GBP

COMMON STOCK

CFD

SHORT

1,782

49.5781 GBP

COMMON STOCK

CFD

SHORT

92

49.5781 GBP

COMMON STOCK

CFD

SHORT

834

49.7588 GBP

COMMON STOCK

CFD

SHORT

594

49.7674 GBP

COMMON STOCK

CFD

SHORT

321

49.7674 GBP

COMMON STOCK

CFD

SHORT

744

49.7700 GBP

COMMON STOCK

CFD

SHORT

4,687

49.7700 GBP

COMMON STOCK

CFD

SHORT

748

49.7700 GBP

COMMON STOCK

CFD

SHORT

50

49.7700 GBP

COMMON STOCK

CFD

SHORT

6,153

49.7700 GBP

COMMON STOCK

CFD

SHORT

667

49.7950 GBP

COMMON STOCK

CFD

SHORT

372

49.8000 GBP

COMMON STOCK

CFD

SHORT

13,785

49.8065 GBP

COMMON STOCK

CFD

SHORT

53

49.8479 GBP

COMMON STOCK

CFD

SHORT

411,294

49.8676 GBP

COMMON STOCK

CFD

SHORT

590

49.8764 GBP

COMMON STOCK

CFD

SHORT

51,701

49.8870 GBP

COMMON STOCK

CFD

SHORT

22,597

49.9398 GBP

COMMON STOCK

CFD

SHORT

18,807

84.9351 GBP

COMMON STOCK

CFD

SHORT

917

84.9351 GBP

COMMON STOCK

CFD

SHORT

278

84.9351 GBP

COMMON STOCK

CFD

SHORT

622

84.9351 GBP

COMMON STOCK

CFD

SHORT

10,425

84.9351 GBP

(c) Options transactions in respect of existing securities

(i) Writing, selling, purchasing or varying

Class of relevant security

Product description e.g. call option

Writing, purchasing, selling, varying etc.

Number of securities to which option relates

Exercise price per unit

Type e.g. American, European etc.

Expiry date

Option money paid/ received per unit

N/A

N/A

N/A

N/A

N/A

N/A

N/A

N/A

(ii) Exercising

Class of relevant security

Product description e.g. call option

Number of securities

Exercise price per unit

N/A

N/A

N/A

N/A

(d) Other dealings (including subscribing for new securities)

Class of relevant security

Nature of dealing e.g. subscription, conversion

Details

Price per unit (if applicable)

N/A

N/A

N/A

N/A

The currency of all prices and other monetary amounts should be stated.

Where there have been dealings in more than one class of relevant securities of the offeror or offeree named in 1(b), copy table 2(a), (b), (c) or (d) (as appropriate) for each additional class of relevant security dealt in.

3. OTHER INFORMATION

(a) Indemnity and other dealing arrangements

Details of any indemnity or option arrangement, or any agreement or understanding, formal or informal, relating to relevant securities which may be an inducement to deal or refrain from dealing entered into by the exempt principal trader making the disclosure and any party to the offer or any person acting in concert with a party to the offer:

If there are no such agreements, arrangements or understandings, state "none"

None

(b) Agreements, arrangements or understandings relating to options or derivatives

Details of any agreement, arrangement or understanding, formal or informal, between the exempt principal trader making the disclosure and any other person relating to:

(i) the voting rights of any relevant securities under any option; or

(ii) the voting rights or future acquisition or disposal of any relevant securities to which any derivative is referenced:

If there are no such agreements, arrangements or understandings, state "none"

None

Date of disclosure:

25 JULY 2014

Contact name:

Darren Wickert

Telephone number:

+44 (0)20 7425 6578

Public disclosures under Rule 8 of the Code must be made to a Regulatory Information Service and must also be emailed to the Takeover Panel atmonitoring@disclosure.org.uk. The Panel's Market Surveillance Unit is available for consultation in relation to the Code's dealing disclosure requirements on +44 (0)20 7638 0129.

The Code can be viewed on the Panel's website atwww.thetakeoverpanel.org.uk.


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