Morgan Stanley Securities Limited



AMENDMENT (Section 2(b))

FORM 8.5 (EPT/RI)

PUBLIC DEALING DISCLOSURE BY AN EXEMPT PRINCIPAL TRADER WITH RECOGNISED INTERMEDIARY STATUS DEALING IN A CLIENT-SERVING CAPACITY

Rule 8.5 of the Takeover Code (the "Code")

1. KEY INFORMATION

(a) Name of exempt principal trader:

Morgan Stanley Securities Limited

(b) Name of offeror/offeree in relation to whose relevant securities this form relates:

Use a separate form for each offeror/offeree

SHIRE PLC

(c) Name of the party to the offer with which exempt principal trader is connected:

SHIRE PLC

(d) Date dealing undertaken:

26 AUGUST 2014

(e) Has the EPT previously disclosed, or is it today disclosing, under the Code in respect of any other party to this offer?

Yes

2. DEALINGS BY THE EXEMPT PRINCIPAL TRADER

(a) Purchases and sales

Class of relevant security

Purchases/sales

Total number of securities

Highest price per unit paid/received

Lowest price per unit paid/received

COMMON STOCK

PURCHASES

370,287

49.1600 GBP

48.4800 GBP

COMMON STOCK

SALES

495,643

49.1661 GBP

48.4800 GBP

(b) Derivatives transactions (other than options)

Class of relevant security

Product description

e.g. CFD

Nature of dealing

e.g. opening/closing a long/short position, increasing/reducing a long/short position

Number of reference securities

Price per unit

COMMON STOCK

CFD

LONG

176

48.5200 GBP

COMMON STOCK

CFD

LONG

380

48.5300 GBP

COMMON STOCK

CFD

LONG

247

48.5320 GBP

COMMON STOCK

CFD

LONG

263

48.5334 GBP

COMMON STOCK

CFD

LONG

625

48.5400 GBP

COMMON STOCK

CFD

LONG

95

48.5445 GBP

COMMON STOCK

CFD

LONG

1,454

48.6750 GBP

COMMON STOCK

CFD

LONG

212

48.8128 GBP

COMMON STOCK

CFD

LONG

67,970

48.8290 GBP

COMMON STOCK

CFD

LONG

1,925

48.8290 GBP

COMMON STOCK

CFD

LONG

2,820

48.8540 GBP

COMMON STOCK

CFD

LONG

21,307

48.8710 GBP

COMMON STOCK

CFD

LONG

28,693

48.8710 GBP

COMMON STOCK

CFD

LONG

44,745

48.9010 GBP

COMMON STOCK

CFD

LONG

60,255

48.9010 GBP

COMMON STOCK

CFD

LONG

29

48.9028 GBP

COMMON STOCK

CFD

LONG

2,000

48.9600 GBP

COMMON STOCK

CFD

LONG

15,759

49.0217 GBP

COMMON STOCK

CFD

LONG

3,895

49.0217 GBP

COMMON STOCK

CFD

LONG

352

49.0638 GBP

COMMON STOCK

CFD

LONG

78

49.0638 GBP

COMMON STOCK

CFD

LONG

1,411

49.0638 GBP

COMMON STOCK

CFD

LONG

11,209

49.0855 GBP

COMMON STOCK

CFD

LONG

23,326

49.1600 GBP

COMMON STOCK

CFD

LONG

873

49.1600 GBP

COMMON STOCK

CFD

LONG

741

49.1600 GBP

COMMON STOCK

CFD

LONG

1,698

49.1600 GBP

COMMON STOCK

CFD

LONG

5

49.1600 GBP

COMMON STOCK

CFD

LONG

2,177

49.1600 GBP

COMMON STOCK

CFD

LONG

3,345

49.1600 GBP

COMMON STOCK

CFD

SHORT

4,375

48.5549 GBP

COMMON STOCK

CFD

SHORT

87

48.6700 GBP

COMMON STOCK

CFD

SHORT

63,708

48.8178 GBP

COMMON STOCK

CFD

SHORT

2,607

48.8514 GBP

COMMON STOCK

CFD

SHORT

145

48.8514 GBP

COMMON STOCK

CFD

SHORT

651

48.8514 GBP

COMMON STOCK

CFD

SHORT

4,432

48.8655 GBP

COMMON STOCK

CFD

SHORT

16,982

48.8663 GBP

COMMON STOCK

CFD

SHORT

32

48.9043 GBP

COMMON STOCK

CFD

SHORT

2,014

48.9157 GBP

COMMON STOCK

CFD

SHORT

65

48.9716 GBP

COMMON STOCK

CFD

SHORT

17

48.9894 GBP

COMMON STOCK

CFD

SHORT

2,000

48.9918 GBP

COMMON STOCK

CFD

SHORT

54

49.0087 GBP

COMMON STOCK

CFD

SHORT

1,996

49.0091 GBP

COMMON STOCK

CFD

SHORT

18

49.0200 GBP

COMMON STOCK

CFD

SHORT

1,404

49.0639 GBP

COMMON STOCK

CFD

SHORT

73

49.0750 GBP

COMMON STOCK

CFD

SHORT

2,746

49.1600 GBP

COMMON STOCK

CFD

SHORT

36,373

49.1600 GBP

COMMON STOCK

CFD

SHORT

1,462

49.1600 GBP

COMMON STOCK

CFD

SHORT

165

49.1600 GBP

COMMON STOCK

CFD

SHORT

6,688

49.1600 GBP

COMMON STOCK

CFD

SHORT

12,970

49.1600 GBP

COMMON STOCK

CFD

SHORT

143,887

49.1600 GBP

(c) Options transactions in respect of existing securities

(i) Writing, selling, purchasing or varying

Class of relevant security

Product description e.g. call option

Writing, purchasing, selling, varying etc.

Number of securities to which option relates

Exercise price per unit

Type e.g. American, European etc.

Expiry date

Option money paid/ received per unit

N/A

N/A

N/A

N/A

N/A

N/A

N/A

N/A

(ii) Exercising

Class of relevant security

Product description e.g. call option

Number of securities

Exercise price per unit

N/A

N/A

N/A

N/A

(d) Other dealings (including subscribing for new securities)

Class of relevant security

Nature of dealing e.g. subscription, conversion

Details

Price per unit (if applicable)

N/A

N/A

N/A

N/A

The currency of all prices and other monetary amounts should be stated.

Where there have been dealings in more than one class of relevant securities of the offeror or offeree named in 1(b), copy table 2(a), (b), (c) or (d) (as appropriate) for each additional class of relevant security dealt in.

3. OTHER INFORMATION

(a) Indemnity and other dealing arrangements

Details of any indemnity or option arrangement, or any agreement or understanding, formal or informal, relating to relevant securities which may be an inducement to deal or refrain from dealing entered into by the exempt principal trader making the disclosure and any party to the offer or any person acting in concert with a party to the offer:

If there are no such agreements, arrangements or understandings, state "none"

None

(b) Agreements, arrangements or understandings relating to options or derivatives

Details of any agreement, arrangement or understanding, formal or informal, between the exempt principal trader making the disclosure and any other person relating to:

(i) the voting rights of any relevant securities under any option; or

(ii) the voting rights or future acquisition or disposal of any relevant securities to which any derivative is referenced:

If there are no such agreements, arrangements or understandings, state "none"

None

Date of disclosure:

28 AUGUST 2014

Contact name:

Darren Wickert

Telephone number:

+44 (0)20 7425 6578

Public disclosures under Rule 8 of the Code must be made to a Regulatory Information Service and must also be emailed to the Takeover Panel atmonitoring@disclosure.org.uk. The Panel's Market Surveillance Unit is available for consultation in relation to the Code's dealing disclosure requirements on +44 (0)20 7638 0129.

The Code can be viewed on the Panel's website atwww.thetakeoverpanel.org.uk.


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