Released : Feb 24, 2017 10:00



Director/PDMR Shareholding

February 24, 2017 - Shire plc (LSE: SHP, NASDAQ: SHPG)

Notification of transactions by person discharging managerial responsibilities
and person closely associated with them

1.   Details of the person discharging managerial responsibilities
     ('PDMR') / person closely associated them ('PCA')

a)   Name              Albert Stroucken / Gerda Stroucken

2.   Reason for the notification

a)   Position / status Non-Executive Director (PDMR) / PCA of Albert
                       Stroucken

b)   Initial           Initial notification
     notification /
     amendment

3.   Details of the issuer, emission allowance participant, auction
     platform, auctioneer or auction monitor

a)   Name              Shire plc

b)   LEI               54930005LQRLI2UXRQ59

4.   Details of the transaction(s): section to be repeated for (i) each
     type of instrument; (ii) each type of transaction; (iii) each date;
     and (iv) each place where transactions have been conducted

a)   Description of    Shire plc American Depositary Shares ('ADSs')
     the financial
     instrument, type
     of instrument

     Identification    ISIN: US82481R1068
     code

b)   Nature of the     Joint acquisition of ADSs by PDMR and PCA
     transaction

c)   Price(s) and              Price(s)                 Volume(s)
     volume(s)
                                       See appendix below

d)   Aggregated         Weighted average price           Volume
     information
                               $180.96                   14,000

e)   Date of the       February 22, 2017
     transaction

f)   Place of the      ARCX, BATS, BYXX, MSCO, NQBX, NQPX, NSDQ, XEDG
     transaction

Appendix

    Place of the        Price(s)       Volume(s)
     transaction

        ARCX             $181.13          100

        ARCX             $180.93          47

        ARCX             $180.93          53

        ARCX             $180.91          100

        ARCX             $181.19          100

        ARCX             $181.17          100

        ARCX             $181.47          100

        ARCX             $181.37          100

        ARCX             $181.63          50

        ARCX             $181.45          100

        ARCX             $181.51          100

        ARCX             $181.51          100

        ARCX             $180.90          100

        ARCX             $180.98          100

        ARCX             $180.77          100

        ARCX             $180.57          100

        ARCX             $180.81          100

        ARCX             $180.83          100

        ARCX             $180.83          100

        BATS             $181.46          100

        BATS             $180.98          30

        BATS             $180.98          70

        BATS             $180.98          100

        BATS             $180.85          100

        BATS             $180.83          100

        BYXX             $181.33          100

        BYXX             $181.32          100

        BYXX             $181.44          12

        BYXX             $181.44          14

        BYXX             $180.85          100

        MSCO             $181.30          100

        MSCO             $181.95          100

        MSCO             $181.19          100

        MSCO             $180.89          300

        MSCO             $180.70          100

        MSCO             $180.75          100

        MSCO             $180.57          100

        MSCO             $180.47          100

        MSCO             $180.45          200

        MSCO             $180.63          100

        MSCO             $180.61          100

        MSCO             $180.52          100

        MSCO             $180.57          100

        MSCO             $180.50          100

        MSCO             $180.63          200

        MSCO             $180.82          100

        MSCO             $180.91          200

        MSCO             $180.91          200

        MSCO             $180.98          100

        MSCO             $180.91          400

        MSCO             $180.84          100

        MSCO             $180.88          100

        MSCO             $180.80          200

        MSCO             $180.84          100

        MSCO             $180.84          200

        MSCO             $180.69          200

        MSCO             $180.94          300

        MSCO             $180.98          100

        MSCO             $180.95          200

        MSCO             $180.83          100

        MSCO             $180.82          200

        MSCO             $181.04           3

        NQBX             $180.79          100

        NQBX             $180.96          100

        NQPX             $181.01          100

        NSDQ             $181.02          100

        NSDQ             $181.13          100

        NSDQ             $180.51          100

        NSDQ             $180.26          26

        NSDQ             $180.26          74

        NSDQ             $180.33          100

        NSDQ             $180.41          100

        NSDQ             $181.20          100

        NSDQ             $181.21          100

        NSDQ             $180.90          100

        NSDQ             $181.03          100

        NSDQ             $181.26          100

        NSDQ             $181.31          100

        NSDQ             $181.31          100

        NSDQ             $181.84          100

        NSDQ             $181.67          100

        NSDQ             $181.65          100

        NSDQ             $181.40          100

        NSDQ             $181.53          15

        NSDQ             $181.53          85

        NSDQ             $181.52          33

        NSDQ             $181.52          67

        NSDQ             $181.38          56

        NSDQ             $181.38          44

        NSDQ             $181.55          100

        NSDQ             $181.43          100

        NSDQ             $181.39          15

        NSDQ             $181.39          85

        NSDQ             $181.37          100

        NSDQ             $181.41          100

        NSDQ             $181.43          100

        NSDQ             $181.29          100

        NSDQ             $180.83          100

        NSDQ             $180.82           1

        NSDQ             $180.82          99

        NSDQ             $180.98          100

        NSDQ             $181.07          100

        NSDQ             $180.76          100

        NSDQ             $180.76           8

        NSDQ             $180.76          92

        NSDQ             $181.02          100

        NSDQ             $180.62          100

        NSDQ             $180.38          100

        NSDQ             $180.29          100

        NSDQ             $180.65          100

        NSDQ             $180.69          39

        NSDQ             $180.69          61

        NSDQ             $181.00          30

        NSDQ             $181.02          70

        NSDQ             $180.85          100

        NSDQ             $180.67          100

        NSDQ             $180.94           8

        NSDQ             $180.94          92

        NSDQ             $180.83          100

        NSDQ             $180.84          100

        NSDQ             $180.83          80

        NSDQ             $180.83          100

        NSDQ             $180.83          100

        NSDQ             $180.83          100

        NSDQ             $180.83          20

        NSDQ             $180.83          100

        NSDQ             $180.82          100

        NSDQ             $181.01          77

        NSDQ             $181.01          77

        NSDQ             $181.01          23

        NSDQ             $181.01          16

        NSDQ             $181.01           7

        NSDQ             $181.01          93

        NSDQ             $181.01           7

        XEDG             $180.61          100

        XEDG             $181.27           5

        XEDG             $181.27          95

        XEDG             $181.08           2

        XEDG             $181.08          98

        XEDG             $180.86          57

        XEDG             $180.86          43

        XEDG             $180.95          100

        XEDG             $181.17          100

        XEDG             $181.12          100

        XEDG             $180.92          100

        XEDG             $180.77          21

        XEDG             $180.87          100

        XEDG             $180.83          100



    Place of the        Weighted      Aggregated
     transaction      average price     volume

        ARCX             $181.09         1,750

        BATS             $181.02          500

        BYXX             $181.19          326

        MSCO             $180.83         4,703

        NQBX             $180.88          200

        NQPX             $181.01          100

        NSDQ             $181.01         5,400

        XEDG             $180.96         1,021

        Total            $180.96        14,000

Oliver Strawbridge

Senior Assistant Company Secretary

For further information please contact:

Investor Relations

Ian Karp                        ikarp@shire.com            +1 781 482 9018

Robert Coates                   rcoates@shire.com          +44 1256 894874

Media

Lisa Adler                      lisa.adler@shire.com       +1 617 588 8607

Debbi Ford                      debbi.ford@shire.com       +1 617 949 9083

NOTES TO EDITORS

About Shire

Shire is the leading global biotechnology company focused on serving people
with rare diseases. We strive to develop best-in-class products, many of which
are available in more than 100 countries, across core therapeutic areas
including Hematology, Immunology, Neuroscience, Ophthalmics, Lysosomal Storage
Disorders, Gastrointestinal / Internal Medicine / Endocrine and Hereditary
Angioedema; and a growing franchise in Oncology.

Our employees come to work every day with a shared mission: to develop and
deliver breakthrough therapies for the hundreds of millions of people in the
world affected by rare diseases and other high-need conditions, and who lack
effective therapies to live their lives to the fullest.

www.shire.com

Shire plc published this content on 24 February 2017 and is solely responsible for the information contained herein.
Distributed by Public, unedited and unaltered, on 24 February 2017 10:08:17 UTC.

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