Shiseido : Wins First Prize and Two Second Prizes for Excellent Research Papers at the 12th China Cosmetics Academic Research Conference

【First Prize】
Title: New insight into the development of anti-aging skincare cosmetics focusing on the primary causes of wrinkles
Presenter: Shiseido Research Center, Yusuke Hara
Overview:
The sites that are prone to wrinkling undergo a high degree of motion during facial expressions; therefore, skin motion may be an essential factor in wrinkle formation. We confirmed an increase in wrinkle volume immediately after facial expressions. The resulting wrinkles were referred to as residual wrinkles, and the mechanically deteriorated stratum corneum (SC) was suggested to be primarily responsible for residual wrinkle formation. An efficient method for repairing deteriorated SC was demonstrated to be the SC hydration-dehydration process, which could be controlled by skincare product ingredients or formulations. In our previous studies, polyoxyethylene/polyoxypropylen dimethyl ether (EPDME) has been confirmed to enhance the SC hydration-dehydration process. EPDME suppressed the formation of residual wrinkles by keeping the moderate moisture in the stratum corneum, and repaired the formed residual wrinkles. The results offer new insights into the development of daily anti-aging skincare cosmetics.

【Second Prize】
Title: Development of breakthrough anti-aging skin care - Discovery of a critical skin-aging mechanism caused by sweat gland shrinkage: dermal cavitation
Presenter: Shiseido Research Center, Tomonobu Ezure
Overview:
To determine the cause of age-related skin sagging, we developed a new micro-computed tomography method to visualize internal skin structures in three dimensions and identified for the first time that multiple defects are filled with adipose tissues ('dermal cavitation') in the deep dermal layer of aged skin. This research revealed that the cavitation significantly decreases skin elasticity and promotes sagging, and that age-induced cavitation is closely connected with atrophic sweat glands, suggesting that sweat glands shrink upwards with aging and create cavities in the dermal layer, which results in skin sagging. As for the means to improve cavitation, we found out for the first time that rosemary extract attracts adipose tissue-derived stem cells (ADSCs) and activates dermal tissues, establishing a three-dimensional dermal structure.

【Second Prize】
Title: A Novel Mechanism of Cutaneous Aging Mediated by the Impairment of Lymphatic Function and the Protective Role of a Lymphatic-promoting Compound
Presenter: Shiseido Research Center, Kentaro Kajiya
Overview:
Skin-aging is thought to be caused partly by the deterioration of the inner part of the body, in particular, the circulatory system, composed of blood and lymphatic vessels. However, very few studies have been conducted on the functions of lymphatic vessels in skin-aging. By visualizing the lymphatic vessels in the skin, we succeeded in revealing that 1) lymphatic vessels are functionally hyper-permeable in aged skin, deteriorating its function of collecting waste products and excess water, 2) sagging skin shows increased subcutaneous adipocyte accumulation and looser, hyper-permeable lymphatic vessel structure, and 3) fatty acids in the lymph promote hyper-permeability of lymphatic vessels, leading to the increase of adipocyte accumulation. Moreover, we found out for the first time age-dependent down-regulation of Tie2 activation that plays an important role in the stabilization of lymphatic vessels, and that cinnamon extract directly activates Tie2 receptor, promotes the stabilization of lymphatic vessels, and controls the accumulation of subcutaneous adipocyte.