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SYSTEM RESEARCH : Investigators from Fudan University Release New Data on Neurobiology (Genetic approaches to access cell types in mammalian nervous systems)

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07/12/2018 | 11:36pm CEST

By a News Reporter-Staff News Editor at Gene Therapy Weekly -- Data detailed on Nervous System Research - Neurobiology have been presented. According to news reporting originating in Shanghai, People's Republic of China, by NewsRx journalists, research stated, "Understanding brain circuit organization and function requires systematic dissection of its cellular components. With vast cell number and diversity, mammalian nervous systems present a daunting challenge for achieving specific and comprehensive cell type access - prerequisite to circuit analysis."

Financial supporters for this research include National Natural Science Foundation of China, Shanghai Science and Technology Commission, National Institute of Health (see also Nervous System Research - Neurobiology).

The news reporters obtained a quote from the research from Fudan University, "Genetic approaches in the mouse have relied on germline engineering to access marker-defined cell populations. Combinatorial strategies that engage marker intersection, anatomy and projection pattern (e.g. antero-grade and retro-grade viral vectors), and developmental lineage substantially increase the specificity of cell type targeting. While increasing number of mouse cell types are becoming experimentally accessible, comprehensive coverage requires larger coordinated efforts with strategic infrastructural and fiscal planning. CRISPR-based genome editing may enable cell type access in other species, but issues of time, cost and ethics remain, especially for primates."

According to the news reporters, the research concluded: "Novel approaches that bypass the germline, such as somatic cell engineering and cell surface-based gene delivery, may reduce the barrier of genetic access to mammalian cell types."

For more information on this research see: Genetic approaches to access cell types in mammalian nervous systems. Current Opinion in Neurobiology, 2018;50():109-118. Current Opinion in Neurobiology can be contacted at: Current Biology Ltd, 84 Theobalds Rd, London WC1X 8RR, England. (Elsevier - www.elsevier.com; Current Opinion in Neurobiology - www.journals.elsevier.com/current-opinion-in-neurobiology/)

Our news correspondents report that additional information may be obtained by contacting M. He, Fudan University, Zhongshan Hosp, Inst Brain Sci, State Key Lab Med NeurobiolDept Neurol, Shanghai 200032, People's Republic of China.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1016/j.conb.2018.02.003. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

Keywords for this news article include: Shanghai, People's Republic of China, Asia, Neurobiology, Nervous System Research, Engineering, Genetics, Fudan University.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2018, NewsRx LLC

(c) 2018 NewsRx LLC, source Health Newsletters

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